Neuro-affective Response to Light in Depressed Adolescents and Young Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-14

Study Completion Date

2026-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are:

* Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals?
* Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than young adults?

Participants will complete:

* A magnetic resonance imaging brain scan, in which we will examine the effect of blue versus red light on emotional brain function at rest and in response to rewards and losses.
* A pupillometry test of sensitivity to blue vs red light
* Clinical interviews and surveys
* Screening measures for drug and alcohol use, MRI safety, and current pregnancy \[if relevant\]
* Home sleep tracking with sleep diary and actigraphy for one week

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Low Intensity 'Blue Light' Treatment of Seasonal Affective Disorder

NCT01149135

Seasonal Affective Disorder

COMPLETED NA

Near-infrared Radiation-transcranial Photobiomodulation for Major Depressive Disorder

NCT04619121

Major Depressive Disorder Oxidative Stress

COMPLETED NA

Neurobiological Effects of Light on MDD

NCT02940769

Major Depressive Disorder

TERMINATED NA

Impact of Light on Mood

NCT06027944

Depression

UNKNOWN NA

Efficacy of Blue Light Treatment in Patients With Nonseasonal Major Depressive Disorder

NCT04555408

Depression

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Depression in Adolescence Depression in Adults

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

All participants will receive blue and red light exposures; order of red vs. blue light will be counterbalanced across participants.

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Blue then Red Light

Blue light (480 nm) then Red light (640 nm)

Group Type EXPERIMENTAL

Blue Light

Intervention Type OTHER

Blue light exposure

Red Light

Intervention Type OTHER

Red light exposure

Red Light then Blue Light

Red light (640 nm) then Blue light (480 nm)

Group Type EXPERIMENTAL

Blue Light

Intervention Type OTHER

Blue light exposure

Red Light

Intervention Type OTHER

Red light exposure

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Blue Light

Blue light exposure

Intervention Type OTHER

Red Light

Red light exposure

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Elevated Depressive Symptoms \[PHQ9≥5 And (Item 1≥1 or Item 2≥1)\]
* (If \<18yr) Parent or guardian can attend the baseline clinical interview

Exclusion Criteria

* Unable to read and write in English
* Intellectual disability.
* Left or mixed handedness
* Changes to psychotropic medication type or dosage in the past 2 months
* Lifetime bipolar disorder or schizophrenia, or substance/alcohol disorder in the past 3 months.
* Factors influencing light and color sensitivity (i.e., color-blindness, serious ophthalmological conditions, photo-sensitizing medication).
* Factors influencing the ability to maintain a stable sleep schedule (i.e., shift work, severe sleep disorders, extremely late or early sleep schedule).
* Severe medical illness, neurological disorders, or history of head trauma.
* Current pregnancy or nursing
* MRI contraindication (e.g., metals in the body, recent tattoo, claustrophobia)
* Positive alcohol or substance use screen at MRI visit

Minimum Eligible Age

12 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No