Pragmatic Approach To Esophageal Dilation

NCT ID: NCT04542551

Last Updated: 2024-01-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

34 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-03-24

Study Completion Date

2023-12-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to better understand the role of a technique called esophageal dilation in patients who complain of trouble swallowing. In patients with esophageal stricture we want to determine if the size of the esophageal dilator makes a difference in symptoms and outcomes. In patients who do not have an obvious esophageal stricture we want to determine if esophageal dilation is an effective therapy in these patients.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dysphagia Swallowing Disorders

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Severe stricture - dilation with 42-Fr

Patients with severe stricture on upper endoscopy will receive dilation with 42-Fr dilator

Group Type ACTIVE_COMPARATOR

Severe stricture - dilation with 42-Fr

Intervention Type PROCEDURE

Dilation of a severe stricture with 42-Fr dilator

Without stricture - dilation with 60-Fr

Patients without stricture on upper endoscopy will receive empiric dilation with 60-Fr dilator

Group Type ACTIVE_COMPARATOR

Dilation 60-Fr non stricture

Intervention Type PROCEDURE

Dilation of patients with subjective dysphagia and normal endoscopy

Without stricture - dilation with 15-Fr

Patients without stricture on upper endoscopy will receive empiric dilation with 15-Fr dilator (sham)

Group Type SHAM_COMPARATOR

Sham

Intervention Type PROCEDURE

Sham dilator for patients with subjective dysphagia and normal endoscopy

Non severe stricture - dilation with 60-Fr

Patients with non-severe stricture on upper endoscopy will receive dilation with 60-Fr dilator

Group Type ACTIVE_COMPARATOR

Non severe stricture - dilation with 60-Fr

Intervention Type PROCEDURE

Dilation of non severe stricture with 60-Fr dilator

Non severe stricture - dilation with 46-Fr

Patients with non-severe stricture on upper endoscopy will receive dilation with 46-Fr dilator

Group Type ACTIVE_COMPARATOR

Non severe stricture - dilation with 46-Fr

Intervention Type PROCEDURE

Dilation of non severe stricture with 46-Fr dilator

Severe stricture - dilation with 51-Fr

Patients with severe stricture on upper endoscopy will receive dilation with 51-Fr dilator

Group Type ACTIVE_COMPARATOR

Severe stricture - dilation with 51-Fr

Intervention Type PROCEDURE

Dilation of a severe stricture with 51-Fr dilator

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Dilation 60-Fr non stricture

Dilation of patients with subjective dysphagia and normal endoscopy

Intervention Type PROCEDURE

Sham

Sham dilator for patients with subjective dysphagia and normal endoscopy

Intervention Type PROCEDURE

Non severe stricture - dilation with 60-Fr

Dilation of non severe stricture with 60-Fr dilator

Intervention Type PROCEDURE

Non severe stricture - dilation with 46-Fr

Dilation of non severe stricture with 46-Fr dilator

Intervention Type PROCEDURE

Severe stricture - dilation with 51-Fr

Dilation of a severe stricture with 51-Fr dilator

Intervention Type PROCEDURE

Severe stricture - dilation with 42-Fr

Dilation of a severe stricture with 42-Fr dilator

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patients with esophageal dysphagia who are 18 years old or older.
2. Patients with dysphagia undergoing Esophagogastroduodenoscopy (EGD).
3. Patients who are able to provide consent for the study.
4. Patients with known esophageal stricture that may have or may not have been dilated before.

Exclusion Criteria

1. Patients with malignant stricture.
2. Pregnant women.
3. Patients with a personal history of esophageal perforation.
4. Patients with achalasia, or globus sensation.
5. Any accessory procedures, like esophageal stenting, excision, steroid injection, or dysphagia treatment currently being done at outside facility.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Louisville

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Stephen McClave

MD, Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Stephen McClave, MD

Role: PRINCIPAL_INVESTIGATOR

University of Louisville School of Medicine

Benjamin Rogers, MD

Role: STUDY_CHAIR

University of Louisville School of Medicine

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

University of Louisville Hospital

Louisville, Kentucky, United States

Site Status

UofL health - Jewish hospital downtown

Louisville, Kentucky, United States

Site Status

Louisville VA Medical Center

Louisville, Kentucky, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

20.0632

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Non-invasive Markers of Esophageal Function in Adults
NCT04074356 ENROLLING_BY_INVITATION NA
Injection Versus Suture Repair of Laryngeal Clefts
NCT07057258 ENROLLING_BY_INVITATION NA