Impact of Fluid Resuscitation Protocol on the Incidence of Reoperation for Bleeding After Emergency Cardiopulmonary Bypass Grafting

NCT ID: NCT04533698

Last Updated: 2025-04-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

265 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-01

Study Completion Date

2024-06-30

Brief Summary

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This is a retrospective data analysis of patients that underwent elective or emergency cardiopulmonary bypass. Resternotomy due to bleeding is frequent after sternotomy. Also due to implementation of Argipressin into clinical practice fluid resuscitation protocol has changed to more vasopressors and less fluid within the past five years. The investigators want to explore the influence of volume resuscitation protocol on incidence of rethoracotomy during the past twenty years.

Detailed Description

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Conditions

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Resternotomy

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Resternotomy

Assessment of reason for resternotomy

Intervention Type OTHER

No intervention is performed. Reasons for resternotomy (coagulation, fluid balance and other) are retrospectively assessed.

No resternotomy

Assessment of reason for avoidance of resternotomy

Intervention Type OTHER

No intervention is performed. Reasons for avoidance resternotomy (coagulation, fluid balance and other) are retrospectively assessed.

Interventions

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Assessment of reason for resternotomy

No intervention is performed. Reasons for resternotomy (coagulation, fluid balance and other) are retrospectively assessed.

Intervention Type OTHER

Assessment of reason for avoidance of resternotomy

No intervention is performed. Reasons for avoidance resternotomy (coagulation, fluid balance and other) are retrospectively assessed.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All patients that underwent elective or emergency aortocoronary bypass at the University Hospital Basel between 2009 and 2020.

Exclusion Criteria

* None.
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Alexa Hollinger

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Bruno J, Varayath M, Gahl B, Miazza J, Gebhard CE, Reuthebuch OT, Eckstein FS, Siegemund M, Hollinger A, Santer D. Conservative fluid resuscitation protocol does not reduce the incidence of reoperation for bleeding after emergency CABG. Sci Rep. 2024 Sep 9;14(1):21037. doi: 10.1038/s41598-024-71028-8.

Reference Type DERIVED
PMID: 39251616 (View on PubMed)

Other Identifiers

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2020-01833

Identifier Type: -

Identifier Source: org_study_id

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