Identification of Prognostic Factors and New Therapeutic Targets in Cutaneous Lymphomas

NCT ID: NCT04520529

Last Updated: 2020-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-30

Study Completion Date

2050-09-30

Brief Summary

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Cutaneous lymphomas are a heterogeneous group of extra-nodal lymphomas. The prognosis of cutaneous lymphomas is extremely variable from one subject to another. In the majority of cases, there is no cure for cutaneous lymphomas. Cutaneous lymphomas primarily affect the skin, and secondarily the blood, lymph nodes and possibly other organs. The discovery of new molecular prognostic factors will allow a better identification of patients at high risk of aggressive evolution and the implementation of a personalized therapeutic strategy. The identification of new therapeutic targets is necessary in order to develop new innovative treatments for cutaneous lymphomas.The primary objective is to identify novel molecular prognostic factors associated with 5-year overall survival in cutaneous lymphoma.

Detailed Description

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Conditions

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Cutaneous Lymphoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Patients with primary cutaneous lymphoma

Group Type OTHER

Biologic Samples

Intervention Type OTHER

* An additional punch from lesion skin as part of a skin biopsy performed as part of routine care.
* an additional blood sample will be collected for research during a blood test performed as part of the patient's routine care.
* In patients with clinical superficial lymphadenopathy or detected by imaging, and undergoing a superficial lymph node biopsy as part of the care, a core biopsy will be dedicated to research.

Interventions

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Biologic Samples

* An additional punch from lesion skin as part of a skin biopsy performed as part of routine care.
* an additional blood sample will be collected for research during a blood test performed as part of the patient's routine care.
* In patients with clinical superficial lymphadenopathy or detected by imaging, and undergoing a superficial lymph node biopsy as part of the care, a core biopsy will be dedicated to research.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age\> 18 years old
* Informed consent signed by the patient
* Suspicion of primary cutaneous lymphoma or confirmed lymphoma according to WHO/ISCL/EORTC criteria

Exclusion Criteria

* Patient under guardianship or curatorship
* Lack of affiliation to social security
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Central Contacts

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Adèle DE MASSON

Role: CONTACT

01 42 49 43 19

Matthieu RESCHE-RIGON

Role: CONTACT

0142499742 ext. 0142499742

Other Identifiers

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APHP190179

Identifier Type: -

Identifier Source: org_study_id

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