Rapid Evaluation of Innovative Intervention Components to Maximize the Health Benefits of Behavioral Obesity Treatment Delivered Online: An Application of Multiphase Optimization Strategy
NCT ID: NCT04520256
Last Updated: 2025-01-15
Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
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COMPLETED
PHASE2/PHASE3
384 participants
INTERVENTIONAL
2020-09-22
2023-05-18
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
DOUBLE
Study Groups
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Core Program Only
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Social Support
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Dysregulated Eating
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Social Support, Dysregulated Eating
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Exercise
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Social Support, Exercise
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Dysregulated Eating, Exercise
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Social Support, Dysregulated Eating, Exercise
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Feedback
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Social Support, Feedback
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Dysregulated Eating, Feedback
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Social Support, Dysregulated Eating, Feedback
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Exercise, Feedback
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Social Support, Exercise, Feedback
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Dysregulated Eating, Exercise, Feedback
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Social Support, Dysregulated Eating, Exercise, Feedback
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Social Support, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Dysregulated Eating, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Social Support, Dysregulated Eating, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Exercise, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Social Support, Exercise, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Dysregulated Eating, Exercise, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Social Support, Dysregulated Eating, Exercise, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Feedback, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Social Support, Feedback, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Dysregulated Eating, Feedback, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Social Support, Dysregulated Eating, Feedback, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Exercise, Feedback, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Social Support, Exercise, Feedback, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Dysregulated Eating, Exercise, Feedback, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Social Support, Dysregulated Eating, Exercise, Feedback, VR
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Online Behavioral Weight Loss Program
A self-guided, online program that helps participants reduce energy intake and gradually increase physical activity.
Virtual Reality for Behavioral Weight Loss Skills Training
This program allows participants to practice behavioral weight loss skills using an online virtual reality system accessed via a Web browser.
Tailored Interactive Video Feedback
Video-recorded messages are used to provide periodic feedback on progress with weight loss, dietary change, and physical activity. Additional videos provide dietary skills training.
Tailored Intervention for Structured Physical Activity
Periodic self-assessment is used to guide selection of a physical activity goal. Home-based instructional videos are provided to help meet the selected goal.
Skills Training for Dysregulated Eating
Periodic self-assessment is used to guide selection of skills training modules designed to counter common causes of dysregulated eating (e.g., boredom, stress).
Platform for Social Support & Friendly Competition
An online platform is provided for participants to connect with each other, support each other, and compete on achievement of behavioral and weight loss milestones.
Eligibility Criteria
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Inclusion Criteria
* Body mass index (BMI) between 25 and 50 kg/m-squared
* Able to walk 2 city blocks without stopping
* Not currently participating in another weight loss program
* Not currently taking weight loss medication
* Has not lost ≥5% of body weight in the 6 months prior to enrolling
* Has not been pregnant within the 6 months prior to enrolling
* Does not plan to become pregnant within 12 months of enrolling
* Denies having a heart condition, chest pain during periods of activity or rest, or loss of consciousness in the 12 months prior to enrolling
* Denies any medical condition that would affect the safety of participating in unsupervised physical activity
* Denies any condition that would result in inability to follow the study protocol, including terminal illness, substance abuse, eating disorder (not including Binge Eating Disorder) and untreated major psychiatric illness
18 Years
70 Years
ALL
No
Sponsors
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The Miriam Hospital
OTHER
Responsible Party
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Locations
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Miriam Hospital Weight Control and Diabetes Resarch Center
Providence, Rhode Island, United States
Countries
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References
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Thomas JG, Goldstein CM, Bond DS, Lillis J, Hekler E, Goldstein SP, Butryn ML, Cao Z, Wing RR. Evaluation of Five Novel Intervention Components in Online Obesity Treatment: Outcomes of a Randomized Factorial Experiment. Obesity (Silver Spring). 2025 Sep 18. doi: 10.1002/oby.70039. Online ahead of print.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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