Opt-IN: Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity
NCT ID: NCT01814072
Last Updated: 2023-02-01
Study Results
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View full resultsBasic Information
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COMPLETED
PHASE2/PHASE3
562 participants
INTERVENTIONAL
2013-09-30
2017-09-20
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
NONE
Study Groups
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Condition 1
1\) Lifestyle Core; 2) 12 Telephone Coaching Sessions; 3) Report to Primary Care Physician
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Condition 2
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendations to use meal replacements; 5) Buddy training via webinars
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 3
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages; 5) Buddy training via webinars
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Text Messages
Participants will receive regular text messages
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 4
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Text Messages
Participants will receive regular text messages
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Condition 5
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Buddy training via webinars
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 6
1\) Lifestyle Core; 2) 12 telephone coaching sessions; 3) Recommendations to use meal replacements
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Condition 7
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Regular text messages
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Text Messages
Participants will receive regular text messages
Condition 8
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Recommendation to use meal replacements; 4) Regular text messages, 5) Buddy training via webinars
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Text Messages
Participants will receive regular text messages
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 9
1\) Lifestyle Core; 2) 24 telephone coaching sessions; 3) Report to Primary Care Physician
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Condition 10
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Buddy training via webinars
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 11
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages; 5) Buddy training via webinars
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Text Messages
Participants will receive regular text messages
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 12
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Text Messages
Participants will receive regular text messages
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Condition 13
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Buddy training via webinars
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 14
1\) Lifestyle Core; 2) 24 telephone coaching sessions; 3) Recommendation to use meal replacements
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Condition 15
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Regular text messages
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Text Messages
Participants will receive regular text messages
Condition 16
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Recommendation to use meal replacements; 4) Regular text messages, 5) Buddy training via webinars
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Text Messages
Participants will receive regular text messages
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 17
1\) Lifestyle Core; 2) 12 Telephone Coaching Sessions
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Condition 18
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Recommendations to use meal replacements; 4) Buddy training via webinars
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 19
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Regular text messages; 4) Buddy training via webinars
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Text Messages
Participants will receive regular text messages
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 20
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Regular text messages; 4) Recommendation to use meal replacements
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Text Messages
Participants will receive regular text messages
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Condition 21
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Buddy training via webinars
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 22
1\) Lifestyle Core; 2) 12 telephone coaching sessions; 3) Report to Primary Care Physician; 4) Recommendations to use meal replacements
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Condition 23
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Text Messages
Participants will receive regular text messages
Condition 24
1\) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages, 6) Buddy training via webinars
12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Text Messages
Participants will receive regular text messages
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 25
1\) Lifestyle Core; 2) 24 telephone coaching sessions
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Condition 26
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Recommendation to use meal replacements; 4) Buddy training via webinars
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 27
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Regular text messages; 4) Buddy training via webinars
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Text Messages
Participants will receive regular text messages
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 28
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Regular text messages; 4) Recommendation to use meal replacements
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Text Messages
Participants will receive regular text messages
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Condition 29
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Buddy training via webinars
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Condition 30
1\) Lifestyle Core; 2) 24 telephone coaching sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Condition 31
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Text Messages
Participants will receive regular text messages
Condition 32
1\) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages, 6) Buddy training via webinars
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Text Messages
Participants will receive regular text messages
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Interventions
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12 Telephone Coaching Sessions
Participants will receive 12 telephone coaching sessions
24 Telephone Coaching Sessions
Participants will receive 24 telephone coaching sessions
Report to Primary Care Physician
Participants will have a report detailing their weight loss progress sent to their primary care physician
Text Messages
Participants will receive regular text messages
Recommendations to use meal replacements
Participants will receive recommendations from their coach to use meal replacements
Buddy Training
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Eligibility Criteria
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Inclusion Criteria
* BMI 25-40 kg/m2
* Weight stable (no loss or gain \>25 lbs for the past 6 months)
* Not enrolled in any formal weight loss program or taking anti-obesity medications, but interested in losing weight.
* Own a Smartphone and be willing to install the Opt-IN app
* Able to use the app to record dietary intake and weight onto the Smartphone
"Buddy" participants must:
* 18 years of age or older
* Have access to a computer and internet
* Be willing to undergo "Buddy Training" and participate in 4 webinars
* Be willing to provide support and encouragement to the participant
Exclusion Criteria
* History of diabetes requiring insulin supplementation, Crohn's Disease, or a diagnosis of obstructive sleep apnea requiring intervention (i.e. CPAP)
* Use an assistive device for mobility (e.g., wheelchair, walker, cane)
* Plantar fasciitis
* Hospitalization for a psychiatric disorder within the past 5 years
* At risk for adverse cardiovascular (CVD) events with moderate intensity activity
* Cannot read the study questionnaires
* Committed to following an incompatible dietary regimen
* Not be pregnant, trying to get pregnant, or lactating
* Bulimia, binge eating disorder, current substance abuse or dependence (besides nicotine dependence) or report active suicidal ideation
* Low motivation to change
* Cannot live with a current or past Opt-IN participant
18 Years
60 Years
ALL
Yes
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Penn State University
OTHER
Northwestern University
OTHER
Responsible Party
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Bonnie Spring
Professor
Principal Investigators
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Bonnie Spring, PhD
Role: PRINCIPAL_INVESTIGATOR
Northwestern University
Linda Collins, PhD
Role: PRINCIPAL_INVESTIGATOR
Penn State University
Locations
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Northwestern University
Chicago, Illinois, United States
Countries
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References
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Collins LM, Murphy SA, Strecher V. The multiphase optimization strategy (MOST) and the sequential multiple assignment randomized trial (SMART): new methods for more potent eHealth interventions. Am J Prev Med. 2007 May;32(5 Suppl):S112-8. doi: 10.1016/j.amepre.2007.01.022.
Nahum-Shani I, Smith SN, Spring BJ, Collins LM, Witkiewitz K, Tewari A, Murphy SA. Just-in-Time Adaptive Interventions (JITAIs) in Mobile Health: Key Components and Design Principles for Ongoing Health Behavior Support. Ann Behav Med. 2018 May 18;52(6):446-462. doi: 10.1007/s12160-016-9830-8.
Baker TB, Smith SS, Bolt DM, Loh WY, Mermelstein R, Fiore MC, Piper ME, Collins LM. Implementing Clinical Research Using Factorial Designs: A Primer. Behav Ther. 2017 Jul;48(4):567-580. doi: 10.1016/j.beth.2016.12.005. Epub 2017 Jan 7.
Pfammatter AF, Nahum-Shani I, DeZelar M, Scanlan L, McFadden HG, Siddique J, Hedeker D, Spring B. SMART: Study protocol for a sequential multiple assignment randomized controlled trial to optimize weight loss management. Contemp Clin Trials. 2019 Jul;82:36-45. doi: 10.1016/j.cct.2019.05.007. Epub 2019 May 23.
Nahum-Shani I, Dziak JJ, Collins LM. Multilevel factorial designs with experiment-induced clustering. Psychol Methods. 2018 Sep;23(3):458-479. doi: 10.1037/met0000128. Epub 2017 Apr 6.
Terry PE, Brown N, Arnett DK, Cushman M, Spring B, Halpern SD, Burke LE, Grossmeier J, Goetzel R, Lang J, Calitz C, Terry PE, Sanchez E. The Art of Health Promotion ideas for improving health outcomes. Am J Health Promot. 2016 Sep;30(7):563-82. doi: 10.1177/0890117116668866. No abstract available.
Pellegrini CA, Conroy DE, Phillips SM, Pfammatter AF, McFadden HG, Spring B. Daily and Seasonal Influences on Dietary Self-monitoring Using a Smartphone Application. J Nutr Educ Behav. 2018 Jan;50(1):56-61.e1. doi: 10.1016/j.jneb.2016.12.004.
Welch WA, Spring B, Phillips SM, Siddique J. Moderating Effects of Weather-Related Factors on a Physical Activity Intervention. Am J Prev Med. 2018 May;54(5):e83-e89. doi: 10.1016/j.amepre.2018.01.025. Epub 2018 Mar 15.
Burke LE, Ma J, Azar KM, Bennett GG, Peterson ED, Zheng Y, Riley W, Stephens J, Shah SH, Suffoletto B, Turan TN, Spring B, Steinberger J, Quinn CC; American Heart Association Publications Committee of the Council on Epidemiology and Prevention, Behavior Change Committee of the Council on Cardiometabolic Health, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology, Council on Quality of Care and Outcomes Research, and Stroke Council. Current Science on Consumer Use of Mobile Health for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association. Circulation. 2015 Sep 22;132(12):1157-213. doi: 10.1161/CIR.0000000000000232. Epub 2015 Aug 13. No abstract available.
Piper ME, Cook JW, Schlam TR, Jorenby DE, Smith SS, Collins LM, Mermelstein R, Fraser D, Fiore MC, Baker TB. A Randomized Controlled Trial of an Optimized Smoking Treatment Delivered in Primary Care. Ann Behav Med. 2018 Sep 13;52(10):854-864. doi: 10.1093/abm/kax059.
Booth JN 3rd, Allen NB, Calhoun D, Carson AP, Deng L, Goff DC Jr, Redden DT, Reis JP, Shimbo D, Shikany JM, Sidney S, Spring B, Lewis CE, Muntner P. Racial Differences in Maintaining Optimal Health Behaviors Into Middle Age. Am J Prev Med. 2019 Mar;56(3):368-375. doi: 10.1016/j.amepre.2018.10.020.
Spring B, Pfammatter A, Alshurafa N. First Steps Into the Brave New Transdiscipline of Mobile Health. JAMA Cardiol. 2017 Jan 1;2(1):76-78. doi: 10.1001/jamacardio.2016.4440. No abstract available.
Hoffman SA, Ledford G, Cameron KA, Phillips SM, Pellegrini CA. A qualitative exploration of social and environmental factors affecting diet and activity in knee replacement patients. J Clin Nurs. 2019 Apr;28(7-8):1156-1163. doi: 10.1111/jocn.14719. Epub 2018 Dec 10.
Hekler EB, Michie S, Pavel M, Rivera DE, Collins LM, Jimison HB, Garnett C, Parral S, Spruijt-Metz D. Advancing Models and Theories for Digital Behavior Change Interventions. Am J Prev Med. 2016 Nov;51(5):825-832. doi: 10.1016/j.amepre.2016.06.013.
Kheirkhahan M, Tudor-Locke C, Axtell R, Buman MP, Fielding RA, Glynn NW, Guralnik JM, King AC, White DK, Miller ME, Siddique J, Brubaker P, Rejeski WJ, Ranshous S, Pahor M, Ranka S, Manini TM. Actigraphy features for predicting mobility disability in older adults. Physiol Meas. 2016 Oct;37(10):1813-1833. doi: 10.1088/0967-3334/37/10/1813. Epub 2016 Sep 21.
Collins LM, Kugler KC, Gwadz MV. Optimization of Multicomponent Behavioral and Biobehavioral Interventions for the Prevention and Treatment of HIV/AIDS. AIDS Behav. 2016 Jan;20 Suppl 1(0 1):S197-214. doi: 10.1007/s10461-015-1145-4.
Piper ME, Schlam TR, Cook JW, Smith SS, Bolt DM, Loh WY, Mermelstein R, Collins LM, Fiore MC, Baker TB. Toward precision smoking cessation treatment I: Moderator results from a factorial experiment. Drug Alcohol Depend. 2017 Feb 1;171:59-65. doi: 10.1016/j.drugalcdep.2016.11.025. Epub 2016 Nov 25.
Piper ME, Fiore MC, Smith SS, Fraser D, Bolt DM, Collins LM, Mermelstein R, Schlam TR, Cook JW, Jorenby DE, Loh WY, Baker TB. Identifying effective intervention components for smoking cessation: a factorial screening experiment. Addiction. 2016 Jan;111(1):129-41. doi: 10.1111/add.13162. Epub 2015 Nov 19.
Collins LM, Dziak JJ, Kugler KC, Trail JB. Factorial experiments: efficient tools for evaluation of intervention components. Am J Prev Med. 2014 Oct;47(4):498-504. doi: 10.1016/j.amepre.2014.06.021. Epub 2014 Aug 1.
Spring B, Pellegrini CA, Pfammatter A, Duncan JM, Pictor A, McFadden HG, Siddique J, Hedeker D. Effects of an abbreviated obesity intervention supported by mobile technology: The ENGAGED randomized clinical trial. Obesity (Silver Spring). 2017 Jul;25(7):1191-1198. doi: 10.1002/oby.21842. Epub 2017 May 11.
Pellegrini CA, Pfammatter AF, Conroy DE, Spring B. Smartphone applications to support weight loss: current perspectives. Adv Health Care Technol. 2015 Jul;1:13-22. doi: 10.2147/AHCT.S57844.
Spring B, Ockene JK, Gidding SS, Mozaffarian D, Moore S, Rosal MC, Brown MD, Vafiadis DK, Cohen DL, Burke LE, Lloyd-Jones D; American Heart Association Behavior Change Committee of the Council on Epidemiology and Prevention, Council on Lifestyle and Cardiometabolic Health, Council for High Blood Pressure Research, and Council on Cardiovascular and Stroke Nursing. Better population health through behavior change in adults: a call to action. Circulation. 2013 Nov 5;128(19):2169-76. doi: 10.1161/01.cir.0000435173.25936.e1. Epub 2013 Oct 7. No abstract available.
Baker TB, Collins LM, Mermelstein R, Piper ME, Schlam TR, Cook JW, Bolt DM, Smith SS, Jorenby DE, Fraser D, Loh WY, Theobald WE, Fiore MC. Enhancing the effectiveness of smoking treatment research: conceptual bases and progress. Addiction. 2016 Jan;111(1):107-16. doi: 10.1111/add.13154. Epub 2015 Nov 19.
Pellegrini CA, Hoffman SA, Daly ER, Murillo M, Iakovlev G, Spring B. Acceptability of smartphone technology to interrupt sedentary time in adults with diabetes. Transl Behav Med. 2015 Sep;5(3):307-14. doi: 10.1007/s13142-015-0314-3.
Piper ME, Cook JW, Schlam TR, Smith SS, Bolt DM, Collins LM, Mermelstein R, Fiore MC, Baker TB. Toward precision smoking cessation treatment II: Proximal effects of smoking cessation intervention components on putative mechanisms of action. Drug Alcohol Depend. 2017 Feb 1;171:50-58. doi: 10.1016/j.drugalcdep.2016.11.027. Epub 2016 Nov 24.
Schlam TR, Fiore MC, Smith SS, Fraser D, Bolt DM, Collins LM, Mermelstein R, Piper ME, Cook JW, Jorenby DE, Loh WY, Baker TB. Comparative effectiveness of intervention components for producing long-term abstinence from smoking: a factorial screening experiment. Addiction. 2016 Jan;111(1):142-55. doi: 10.1111/add.13153. Epub 2015 Nov 19.
Watkins E, Newbold A, Tester-Jones M, Javaid M, Cadman J, Collins LM, Graham J, Mostazir M. Implementing multifactorial psychotherapy research in online virtual environments (IMPROVE-2): study protocol for a phase III trial of the MOST randomized component selection method for internet cognitive-behavioural therapy for depression. BMC Psychiatry. 2016 Oct 6;16(1):345. doi: 10.1186/s12888-016-1054-8.
Collins LM, Nahum-Shani I, Almirall D. Optimization of behavioral dynamic treatment regimens based on the sequential, multiple assignment, randomized trial (SMART). Clin Trials. 2014 Aug;11(4):426-434. doi: 10.1177/1740774514536795. Epub 2014 Jun 5.
Cook JW, Collins LM, Fiore MC, Smith SS, Fraser D, Bolt DM, Baker TB, Piper ME, Schlam TR, Jorenby D, Loh WY, Mermelstein R. Comparative effectiveness of motivation phase intervention components for use with smokers unwilling to quit: a factorial screening experiment. Addiction. 2016 Jan;111(1):117-28. doi: 10.1111/add.13161. Epub 2015 Nov 19.
Pellegrini CA, Hoffman SA, Collins LM, Spring B. Optimization of remotely delivered intensive lifestyle treatment for obesity using the Multiphase Optimization Strategy: Opt-IN study protocol. Contemp Clin Trials. 2014 Jul;38(2):251-9. doi: 10.1016/j.cct.2014.05.007. Epub 2014 May 17.
Pellegrini CA, Hoffman SA, Collins LM, Spring B. Corrigendum to "Optimization of remotely delivered intensive lifestyle treatment for obesity using the Multiphase Optimization Strategy: Opt-IN study protocol" [Contemp. Clin. Trials 38 (2014) 251-259]. Contemp Clin Trials. 2015 Nov;45(Pt B):468-469. doi: 10.1016/j.cct.2015.09.001. Epub 2015 Nov 29. No abstract available.
Spring B, Pfammatter AF, Marchese SH, Stump T, Pellegrini C, McFadden HG, Hedeker D, Siddique J, Jordan N, Collins LM. A Factorial Experiment to Optimize Remotely Delivered Behavioral Treatment for Obesity: Results of the Opt-IN Study. Obesity (Silver Spring). 2020 Sep;28(9):1652-1662. doi: 10.1002/oby.22915. Epub 2020 Jul 12.
Pfammatter AF, Marchese SH, Pellegrini C, Daly E, Davidson M, Spring B. Using the Preparation Phase of the Multiphase Optimization Strategy to Develop a Messaging Component for Weight Loss: Formative and Pilot Research. JMIR Form Res. 2020 May 13;4(5):e16297. doi: 10.2196/16297.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Document Type: Informed Consent Form
Other Identifiers
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NIH NIDDK R01DK097364-01
Identifier Type: -
Identifier Source: org_study_id
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