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Assessment of Factors That Affected Respiratory Parameters in Mucopolysaccharidoses Patients

NCT ID: NCT04491747

Last Updated: 2020-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

24 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-02-01

Study Completion Date

2020-02-01

Brief Summary

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Respiratory system affects in mucopolysaccharidosis (MPS) disease. Respiratory system symptoms are seen in almost every MPS patients and respiratory failure is one of the most common causes of death in this population. The aim of the study was to evaluate respiratory muscle strength and endurance, cough effectiveness and functional capacity in MPS patients and to defined the factors that affected the respiratory problem in this.

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Detailed Description

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This study was participated MPS patients. Patients' pulmonary function test, functional capacity, respiratory muscle strength and endurance, peak cough flow was assessed and recorded.

Pulmonary function test was assessed with spirometry, functional capacity was evaluated with 3-minute step test and six minute walk test (MWT). Respiratory muscle strength was evaluated mouth pressure measurement (MIP- maximal inspiratory pressure and MEP- maximal expiratory pressure) and Sniff nasal inspiratory pressure (SNIP). Respiratory muscle endurance was assessed Powerbreathe. And cough effectiveness was evaluated peak cough flow.

Conditions

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Mucopolysaccharidoses

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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functional capacity

Six minute walk test used assessment of functional capacity.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Exercise capacity

Eligibility Criteria

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Inclusion Criteria

* People who diagnosed Mucopolysaccharidoses disease in Hacettepe University.
* Cooperation

Exclusion Criteria

* Patients who were not walking ability.
Minimum Eligible Age

7 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hacettepe University

OTHER

Sponsor Role lead

Responsible Party

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Kübra Kılıç

Physiotherapist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Deniz Dogru- Ersoz, Professor

Role: STUDY_DIRECTOR

Hacettepe University

Naciye Vardar- Yagli, PhD

Role: STUDY_CHAIR

Hacettepe University

Dilber Ademhan- Tural, MD

Role: STUDY_CHAIR

Hacettepe University

Nural Kiper, Professor

Role: STUDY_CHAIR

Hacettepe University

Ugur Ozcelik, Professor

Role: STUDY_CHAIR

Hacettepe University

Ebru Yalcin, Professor

Role: STUDY_CHAIR

Hacettepe University

Deniz Inal-Ince, Professor

Role: STUDY_CHAIR

Hacettepe University

Melda Saglam, PhD

Role: STUDY_CHAIR

Hacettepe University

Serap Sivri, Professor

Role: STUDY_CHAIR

Hacettepe University

Aysegul Tokatlı, Professor

Role: STUDY_CHAIR

Hacettepe University

Locations

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Hacettepe University

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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GO 19/97

Identifier Type: -

Identifier Source: org_study_id

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