Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy

NCT ID: NCT02034305

Last Updated: 2024-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

7 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-31

Study Completion Date

2021-01-01

Brief Summary

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This study is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP ,SNIP, and spirometry) can predict spontaneous cough clearance (as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.

Detailed Description

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Conditions

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Duchenne Muscular Dystrophy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Age 6-21; able to cooperate with study procedures
* Duchenne Muscular Dystrophy OR Becker Muscular Dystrophy

Exclusion Criteria

* Need for mechanical ventilation during the day
* Recent (within 2 weeks) lower respiratory tract infection
Minimum Eligible Age

6 Years

Maximum Eligible Age

21 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Respirtech, Inc.

INDUSTRY

Sponsor Role collaborator

University of Pittsburgh

OTHER

Sponsor Role lead

Responsible Party

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Daniel J. Weiner

Associate Professor of Pediatrics

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

References

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Weiner DJ, Abdel-Hamid H, Corcoran TE. Pilot study of nuclear scintigraphy to assess cough clearance in DMD. Pediatr Pulmonol. 2022 Jul;57(7):1776-1778. doi: 10.1002/ppul.25894. Epub 2022 May 5. No abstract available.

Reference Type DERIVED
PMID: 35293696 (View on PubMed)

Other Identifiers

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PRO11100704

Identifier Type: -

Identifier Source: org_study_id

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