Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
12 participants
OBSERVATIONAL
2020-01-01
2020-03-31
Brief Summary
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Primary cultures of orbital fibroblasts from GO and control patients will be established. Cell proliferation, release of hyaluronic acid (HA) and HA synthases (HAS) will be measured. Next Generation Sequencing and gene expression analysis of the whole genome will be performed, as well as global DNA methylation assay.
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Detailed Description
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Cell proliferation and HA will be measured using commercial assays DNA and RNA will be extracted. HAS-1, HAS-2 and HAS-3 will be measured were assessed by Real Time-PCR Next Generation Sequencing, Gene expression analysis and DNA methylation assays will be performed
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Graves' Orbitopathy
Graves' Orbitopathy patients who undergoing orbital decompressive surgery
No Intervention
Not applicable to these subjects. There is no study-related intervention
Control Patients
Patients undergoing eye surgery for unrelated reasons
No Intervention
Not applicable to these subjects. There is no study-related intervention
Interventions
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No Intervention
Not applicable to these subjects. There is no study-related intervention
Eligibility Criteria
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Inclusion Criteria
* Informed consent
Exclusion Criteria
18 Years
85 Years
ALL
No
Sponsors
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University of Pisa
OTHER
Responsible Party
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Marinò Michele
Associate Professor
Locations
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Ospedale Cisanello-Endocrinology I and II
Pisa, , Italy
Countries
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References
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Rotondo Dottore G, Bucci I, Lanzolla G, Dallan I, Sframeli A, Torregrossa L, Casini G, Basolo F, Figus M, Nardi M, Marcocci C, Marino M. Genetic Profiling of Orbital Fibroblasts from Patients with Graves' Orbitopathy. J Clin Endocrinol Metab. 2021 Apr 23;106(5):e2176-e2190. doi: 10.1210/clinem/dgab035.
Other Identifiers
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GeneGO
Identifier Type: -
Identifier Source: org_study_id
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