Survey of Patients With Idiopathic Orbital Inflammation Syndrome

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

87 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-03-03

Study Completion Date

2017-06-03

Brief Summary

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The purpose of this study is to characterise the clinical features, histopathology and the treatment outcomes of patients with idiopathic orbital inflammation syndrome.

Detailed Description

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Idiopathic orbital inflammatory syndrome (IOIS) is a heterogeneous group of disorders characterised by orbital inflammation without any identifiable local or systemic causes. It is a rare clinical entity and a diagnosis of exclusion. Lymphomas, thyroid eye diseases or systemic diseases can have similar presentation and so, a histopathological diagnosis is considered important. IOIS is a difficult condition to treat. Compilation of reported small series of patients with IOIS suggested that they require multiple systemic immunosuppressant drugs and radiotherapy. Recently, a large monocentric study including patients with biopsy proven IOIS showed that up to 40% of them can relapse. Their clinical and pathological features did not correlate with treatments outcomes. The investigators decide therefore to conduct a multicentric retro/ prospective study to determine clinical features, histopathology and treatment outcomes of French patients with IOIS.

Conditions

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Orbital Ischemic Syndrome Orbital Pseudotumor

Keywords

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Observational study IOIS Orbital Pseudotumor Outcome Treatment

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with biopsy proven IOIS or presumed IOIS
* Patients with chronic IOS
* Patient with inaugural IOIS or being treated for IOIS

* Patients with systemic disease-associated IOIS
* Incomplete follow-up of patients treated for IOIS

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sébastien ABAD, MD

Role: PRINCIPAL_INVESTIGATOR

Assistance Publique - Hôpitaux de Paris

Locations

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Service de Médecine interne - Hôpital Avicenne

Bobigny, , France

Site Status

Countries

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France

Other Identifiers

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2010-A00512-37

Identifier Type: OTHER

Identifier Source: secondary_id

NI08014

Identifier Type: -

Identifier Source: org_study_id