A Retrospective Cohort Study: Influence of MTHFR C677T and A1298C Polymorphisms on the Survival of Pediatric Patients With Non-Hodgkin's Lymphoma

NCT ID: NCT04469543

Last Updated: 2020-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

374 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-20

Study Completion Date

2020-05-20

Brief Summary

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The primary purpose of this retrospective study was to investigate the influence of methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism on the survival of pediatric patients with Non-Hodgkin lymphoma (NHL) treated with modified NHL-BFM95 protocol in south China.

Detailed Description

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Conditions

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Pediatric Non-Hodgkin Lymphoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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MTHFR polymorphism

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. aged ≤ 18 years;
2. newly diagnosed as the four main categories of NHL(Burkitt's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma, and diffuse large B-cell lymphoma) between 2014 and 2020;
3. treated according to the modified BFM95 protocol.

Exclusion Criteria

1. aged \> 18 years;
2. not newly diagnosed as the four main categories of NHL between 2014 and 2020;
3. treated according to chemotherapeutic regimens except for the modified BFM95 protocol.
Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Xiao-Fei Sun

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sun Yat-Sen University Cancer Center

Guangzhou, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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SCCCG-NHL2017

Identifier Type: -

Identifier Source: org_study_id

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