A Phase I/II Study of Diffuse Large B-cell Lymphoma

NCT ID: NCT04856137

Last Updated: 2021-04-23

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 74 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-05-01
• Study Completion Date: 2028-12-31

Brief Summary

For continuous variables, mean, median, minimum, and maximum will be used for the descriptive purpose. For categorical variables, frequency and percentage will be used for descriptive statistics. The variables of OS will be estimated by the Kaplan-Meier method. Differences between groups will be calculated using the log-rank test for univariate analysis. Cox's proportional hazards model will be employed to test independent prognostic factors. All calculations will be performed using the Statistical Package of Social Sciences software, version 17.0 (SPSS, Inc., Chicago, IL, USA). The level of statistical significance will be set at 0.05 for all tests.

Detailed Description

This is an open-label, single arm, prospective, multiple-center phase Ib/II study.

In phase Ib, a maximum of 18 patients will be enrolled in the dose-finding period to determine the RP2D, dependent on the toxicity of the study drugs. The response rates of salvage chemotherapy regimen in R/R DLBCL were reported to be within the range of 35-65%.3 Assuming that the response rate of traditional salvage therapy has an overall response rate of 35% (H0=0.35) and that our experimental regimen would increase it to 50% (H1=0.50), the estimated sample size according to the Simon's two-stage minimal design will be 49 in the second phase.1 Briefly, among the 31 patients recruited during the first stage, the response should be seen in at least 10 of the cases, the lowest threshold for the trial to be moved into the second stage of the phase II part. Furthermore, for the RPR regimen to be deemed effective, a response must be demonstrated in at least 21 of the whole 49 patients enrolled in the phase II period. This would achieve a power of 80%, with a two-sided type I error rate of 10%. An additional 7 patients will be recruited, for an estimated dropout rate of 10%.

Conditions

Refractory Diffuse Large B-cell Lymphoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

single arm

ruxolitinib, paclitaxel, and rituximab

Group Type: EXPERIMENTAL

Rituximab Paclitaxel Ruxolitinib

Intervention Type: DRUG

Rituximab 375mg/m2 on D1 of each cycle Paclitaxel 200mg/m2 on D1 of each cycle Ruxolitinib continuously given (D1-21)

Interventions

Rituximab Paclitaxel Ruxolitinib

Rituximab 375mg/m2 on D1 of each cycle Paclitaxel 200mg/m2 on D1 of each cycle Ruxolitinib continuously given (D1-21)

Intervention Type: DRUG

Other Intervention Names

G-CSF 1PC sc qd

Eligibility Criteria

Inclusion Criteria

1. Patients with relapsed/refractory CD20+ diffuse large B-cell lymphoma.

2. Age greater than 20 years and younger than 75 years old.

3. Measurable disease

4. Patients must have an ECOG performance status of less than or equal to 2.

5. Patients must have recovered from toxic effects of all prior therapy before entering onto study.

6. A treatment of drug-free interval of at least 3 weeks since the last dose of chemotherapy is required.

7. More than 4 weeks since prior radiotherapy is required.

8. Adequate bone marrow function

9. Adequate renal function with calculated glomerular filtration rate > 15 mL/min

10. Patients must have adequate liver function

11. All patients must sign a document of informed consent indicating their awareness of the investigational nature and the risks of the study.

Exclusion Criteria

1. Patients who have prior treatment with ruxolitinib or taxane for DLBCL.

2. Pregnant or breast-feeding females.

3. Active or uncontrolled infection.

4. Life expectancy < 6 months

5. Patients with brain or leptomeningeal metastases.

6. Known hypersensitivity to ruxolitinib or paclitaxel

7. Grade III peripheral neuropathy secondary to prior to therapy

8. Second malignancy, except indolent cancers not on active anti-cancer therapy.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Taipei Veterans General Hospital, Taiwan

OTHER_GOV

Sponsor Role: collaborator

Chang Gung Memorial Hospital

OTHER

Sponsor Role: collaborator

China Medical University Hospital

OTHER

Sponsor Role: collaborator

Shin Kong Wu Huo-Shih Memorial Hospital

UNKNOWN

Sponsor Role: collaborator

National Health Research Institutes, Taiwan

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

Chih-Cheng Chen, M.D. Ph.D.

Role: CONTACT

ccchen1968@gmail.com

886-5-3621000 ext. 2852

Hui-Jen Tsai, M.D. Ph.D.

Role: CONTACT

hjtsai@nhri.edu.tw

886-6-7000123 ext. 65149

Other Identifiers

T1420

Identifier Type: -

Identifier Source: org_study_id