Study of the Impact of a School Program Combining - Promotion of HPV Vaccination and HPV Vaccine Offer in Middle School - on Adherence to HPV Vaccination in Middle School Students

NCT ID: NCT04459221

Last Updated: 2022-03-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

355 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-01

Study Completion Date

2021-12-30

Brief Summary

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Cervical cancer (CCU) is the fourth most common cancer in women worldwide. In Reunion island, CCU is the third leading cause of cancer in women (standardized incidence rate on the world population (TIS) in 2013 of 10.3 / 100,000) and is the eighth deadliest cancer with a rate standardized mortality of 4.8 / 100,000, almost three times higher than in mainland France where it was 1.7 / 100,000 in 2018.

CCU results from infection with the human papillomavirus (HPV), which is the most common sexually transmitted viral infection.

CCU prevention is mainly based on cervical smear screening and anti HPV vaccination (VHPV) which has demonstrated its effectiveness on the prevalence of HPV carriage, but also on incidence of condyloma or intermediate grade dysplasia. Since HPV is mainly transmitted sexually, it is important to vaccinate before the start of sex.

In Reunion island, the HPV vaccination coverage rate is the lowest in France, estimated by Public Health France at 8.1% among girls aged 16 years in 2018, while the already low national average was established 23.7%.

Thus, in view of the epidemiological situation in Reunion island (high incidence and mortality for the CCU, very low VHPV coverage rate), we thought it would be interesting to study the impact of a health promotion program sex and prevention of sexually transmitted infections (STIs) including papillomavirus-related pathologies, with a program to promote HPV vaccination among young students in middle school.

Detailed Description

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Conditions

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Papilloma Viral Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Facilitating access to HPV vaccination

Group Type EXPERIMENTAL

Gardasil 9, 9-Valent Intramuscular Suspension

Intervention Type DRUG

access to HPV vaccination near the college in a health bus

promotion of HPV vaccination

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Gardasil 9, 9-Valent Intramuscular Suspension

access to HPV vaccination near the college in a health bus

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* schooled in one of the classes drawn at random in the 2 colleges selected for the study,
* members or beneficiaries of a social security scheme,
* having agreed to participate in the study and whose parents or holder (s) of parental authority have signed a free, informed and written consent.

Exclusion Criteria

* under the age of 9, or over the age of 17 at inclusion,
* with hypersensitivity to the active substances or to any of the excipients of the vaccine (Gardasil 9®),
* with a permanent contraindication to vaccination.
* having already initiated the HPV vaccination (complete or incomplete scheme). Students with an incomplete vaccination schedule will be referred to their attending physician to complete the missing dose (s).
* pregnancy or breastfeeding (based on the declaration)
Minimum Eligible Age

9 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire de la Réunion

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Centre Hospitalier Universitaire de la Réunion

Saint-Pierre, , France

Site Status

Countries

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France

References

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Tran PL, Chirpaz E, Boukerrou M, Bertolotti A. Impact of a Papillomavirus Vaccination Promotion Program in Middle School: Study Protocol for a Cluster Controlled Trial. JMIR Res Protoc. 2022 Jun 13;11(6):e35695. doi: 10.2196/35695.

Reference Type DERIVED
PMID: 35700023 (View on PubMed)

Other Identifiers

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2020-002332-73

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

2020/CHU/05

Identifier Type: -

Identifier Source: org_study_id

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