Influence of Local Anesthetic Administration on the Cancer Recurrence Rate After Pancreatic Oncologic Surgery
NCT ID: NCT04449289
Last Updated: 2020-06-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
PHASE2
100 participants
INTERVENTIONAL
2020-07-01
2024-12-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
As short term endpoints: postoperative complications and resumption of bowel function.
Long term endpoints include: 1 and 3 year recurrence and mortality.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Use of Epidurals Intraoperatively for Patients Undergoing Pancreas Resection
NCT03434678
The Impact of an Epidural Anesthetic on the Consumption of Sevoflurane in Major Abdominal Surgery
NCT04021264
Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes
NCT07207304
Effect of Lidocaine on Postoperative Pain and Long-term Survival in Elderly Patients Undergoing Colorectal Surgery
NCT06405776
Lidocaine Infusion With ERAS Protocol for Pancreatic Cancer Surgery: Effect on Pain and Patient Immunity.
NCT05470166
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Intravenous lidocaine
Patients will be subjected to anesthesia with sevoflurane+fentanyl+intravenous lidocaine infusion for the first 48 hours postoperative
Intravenous lidocaine
Intraoperatively and postoperatively a standard intravenous infusion of lidocaine will be used for analgesia
Epidural ropivacaine
Patients will be subjected to anesthesia with sevoflurane+fentanyl+epidural ropivacaine infusion for the first 48 hours postoperatively
Epidural ropivacaine
Intraoperatively and postoperatively an epidural infusion of ropivacaine will be used for analgesia
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Intravenous lidocaine
Intraoperatively and postoperatively a standard intravenous infusion of lidocaine will be used for analgesia
Epidural ropivacaine
Intraoperatively and postoperatively an epidural infusion of ropivacaine will be used for analgesia
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* American Society of Anesthesiologists (ASA) risk I - III
Exclusion Criteria
* chronic medication that may interfere with pain: antiepileptics, NSAID, corticoids
* contraindications for any of the study medications
* significant psychiatric disorders (major depression, bipolar disorders, schizophrenia, etc.)
* Convulsive disorders requiring medication during the last 2 years
* liver cirrhosis/chronic kidney disease stage IV or V/chronic heart failure class III or IV/ decompensated diabetes
* Corticoid dependent asthma
* Autoimmune disorders
* Anti-arrhythmic medication (verapamil, propafenone, amiodarone) that may interfere with lidocaine's anti-arrhythmic effects
* Refusal for study participation
18 Years
80 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Theodor Bot
PhD student
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Daniela Ionescu, MD PhD
Role: STUDY_DIRECTOR
Regional Institute of Gastroenterology and Hepatology Prof. Dr. O. Fodor
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Regional Institute of Gastroenterology and Hepatology "Prof. Dr. O. Fodor"
Cluj-Napoca, , Romania
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
43/3.02.2020
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.