High Intensity Laser Therapy (HILT) on Myofascial Trigger Points.
NCT ID: NCT04445545
Last Updated: 2025-08-07
Study Results
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Basic Information
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RECRUITING
NA
24 participants
INTERVENTIONAL
2025-05-01
2025-09-01
Brief Summary
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Detailed Description
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Type of study: Experimental, randomized clinical trial (RCT).
1\. Study population.
For the study, students and workers of Andrés Bello University will be considered participants.
2 Randomization and sample.
Participants will be evaluated according to the selection criteria through a survey with closed questions and a clinical examination in which the presence or absence of shortening of upper trapezius muscle shortening will be determined and the presence of a myofascial trigger point (MTrPs) in the muscle. The participants will be chosen according to the selection criteria through a survey with closed questions and a clinical examination in which the presence of muscle shortening of the upper trapezius and the presence of myofascial trigger point in the said muscle. Participants will be divided into three study groups through a simple randomization process; group 1 (HILT), group 2 (sham HILT), and group 3 (HILT). the conventional US). All groups will receive as a basic treatment a therapeutic exercise plan of active static stretching of the upper trapezius muscle of 4 series for 30 seconds. Participants will be scheduled twice a week for four weeks to carry out the assigned treatment.
The sample size will be determined with the G-Power program using a power of 0.85 (1-β), reliability of 95%, an error of 5% (α), and an effect size of d=0.75 (d-Cohen) taking as reference previous studies that have determined the differences in the PPT mean in MTrPs between experimental groups and controls after treatment with HILT.35,49 Based on the above, the sample size is 24 subjects with 8 subjects per group.
3\. Procedures
Participants in each group will be evaluated by two independent examiners to determine cervical spine flexibility (CFROM) and pain intensity (PI), considered the main outcome measures of the study. The range of motion will be measured through goniometry, and pain intensity will be evaluated through algometry, establishing the painful pressure threshold (PPT). The PPT values will be evaluated in kg/cm2, while the CFROM will be evaluated in degrees. The PI and CFROM values will be tabulated in an Excel® spreadsheet for each evaluator.
The evaluations will be carried out during the study in 3 instances (T0-T2) including later 1 follow-up evaluation (T3): pretreatment (T0: baseline), second week (T1: 4th session), fourth week (T2: 8th session). ) and fifth week (T3: follow-up). The participants will be summoned twice a week to carry out their corresponding treatments. On the other hand, cervical disability will be evaluated using the cervical disability index (NDI), obtaining the percentage of disability for each of the evaluation instances. On the other hand, the NDI will be applied as a self-report before and after the treatment sessions (T0 and T2).
Once the study is over, the differences in cervical range of motion (ΔCFROM), pain pressure threshold (ΔPPT), pain intensity (ΔPI), and cervical disability (ΔNDI) between the evaluation sessions will be evaluated.
4\. Variables
4.1 Conceptual definition of the variables.
* Cervical flexibility (CFROM): physical capacity responsible for the voluntary execution of the maximum joint movement of the cervical spine. The CFROM examination will be performed by the participant in a seated position keeping their back straight and supported by a backrest.
* Pain intensity (PI): magnitude of pain reported by the participants after performing the myofascial trigger point (MTrP) algometry test in the shortened upper trapezius muscle after performing the test. The test of the PI will be performed by the participant in a seated position keeping their back straight and supported by a backrest.
* Painful pressure threshold (PPT): magnitude of pressure referred to as painful by the participant when performing the algometry test on the myofascial trigger point (MTrP) of the shortened upper trapezius muscle. The PPT exam will be performed by the participant in a seated position keeping their back straight and supported by a backrest.
* Cervical disability (ND): level of cervical condition reported by the participants that compromise or may compromise the normal development of their activities of daily living.
* High-Intensity Laser Therapy (HILT): laser application with powers greater than 500 milliwatts (mW) in the myofascial trigger point and muscle belly of the upper trapezius.
* Conventional ultrasound (US): application of ultrasound therapy in the myofascial trigger point of the upper trapezius muscle.
* Stretching exercise (SE): active static stretching for the upper trapezius muscle with the presence of myofascial trigger points (positive MTrPs).26,40,41
4.2 Operational definition of variables.
* Cervical flexibility (CFROM): The maximum cervical ranges of motion (CFROM) will be evaluated through an inclinometer (CROM device), recording the degrees of movement for the coronal, sagittal and horizontal planes (Inter-rater reliability: Extension ICC = 0.98 ( 95% CI 0.95, 0.99); Flexion ICC = 0.89 (95% CI 0.73, 0.96); Left Rotation ICC = 0.95 (95% CI 0.87, 0.98); Right Rotation ICC = 0.92 (95% CI 0.80, 0.97); Tilt left ICC = 0.97 (95% CI 0.91, 0.99), right slope ICC = 0.97 (95% CI 0.93, 0.99).
* Painful pressure threshold (PPT): the painful pressure threshold (PPT) will be quantified by algometry, recording the pressure values in kg/cm2 that generate pain in the MTrPs of the upper trapezius muscle (intra-rater reliability: ICC = 0.92-0.98 (CI not reported; inter-rater reliability: ICC = 0.92 (95% CI 0.85,0.97).) The Baseline® brand pressure algometer will be used for the evaluation.
* Cervical Disability (ND): Cervical disability will be evaluated through the Cervical Disability Index (NDI), an instrument that consists of 10 sections with questions related to symptoms and activities of daily living in which the cervical region is involved. Each section costs questions scored from 0-5, with greater disability being linked to a higher score (inter-rater reliability: ICC = 0.93 (95% CI 0.86, 0.97)).
* High-Intensity Laser Therapy (HILT): High-intensity laser therapy (HILT) will be applied to the upper trapezius muscle using the protocol of the study by Dundar et al.48 A total energy delivery of 1,060J divided into 3 phases will be achieved. (phase 1, 500J; phase 2, 60J; phase 3, 500J). It will work with an average power of 3W and an energy density of 50J/cm2. For the application of laser therapy, the 12W BTL-6000 equipment will be used, which emits infrared wavelengths of 1064nm (ANNEX 7).
* Conventional ultrasound (US): the application of ultrasound will be performed with the person in a seated position. The ultrasound parameters will consist of a frequency of 1MHz, the intensity of 1.5 W/cm2, a Duty cycle of 100%, an ERA of 5cm2, and a treatment time of 6 minutes.32 The application of US will be carried out using the COMBI 500 equipment of the company GYMNA®.
* Stretching exercise (SE): 4 sets of active static stretching of the upper trapezius muscle will be performed. Each series will last 30 seconds followed by a rest interval of 30 seconds.
4.3 Variable type definition
* Cervical flexibility (CFROM): dependent, quantitative, discrete variable.
* Pain intensity (PI): dependent, quantitative, discrete variable.
* Painful pressure threshold (PPT): dependent, quantitative, discrete variable.
* Cervical disability (ND): dependent variable, quantitative, continuous.
* High-Intensity Laser Therapy (HILT): independent, quantitative, continuous variable.
* Conventional ultrasound (US): independent, quantitative, continuous variable.
* Stretching exercise (EE): independent, quantitative, discrete variable.
5\. Study phases
Three phases have been designated for the investigation; 1. Sampling phase, 2. Evaluation phase and 3. Intervention phase.
The sampling phase will consist of the application of the selection survey to all students and officials interested in participating in the study. The survey will be applied to them through the Google Drive® system. All those who meet the selection criteria will be invited to participate in the research. This stage will last two weeks.
The evaluation phase will determine a second filter of the population and will include the participants selected by the selection survey who expressed their consent in writing. At this stage, a clinical examination will be performed to determine the presence of shortening of the upper trapezius muscle and myofascial trigger points. The evaluation of the length of the upper trapezius will be carried out by means of an evaluation of the cervical tilt range, while the assessment of the MTrPs will be carried out next in the upper trapezius muscle using the criteria established in the study by Delphi et al. (expert agreement for the diagnosis of MTrPs), in which at least two of the following criteria must be present: 1. taut band, 2. hypersensitive point and 3. pain referred to the compression of the point.24,25 It will be considered as shortened upper trapezius, that muscle contralateral to the lowest degree of cervical inclination measured with an inclinometer. In the event that both trapezius muscles present the same value in degrees, the one that the participant refers to with greater tension will be considered as shortening. The MTrPs examination will be performed by drawing a line between the spinous process of C7 and the midpoint of the upper border of the ipsilateral acromion next to the trapezius evaluated as short, palpating from medial to lateral in search of a point that meets the criteria. exposed. In cases where more than 1 MTrP was located along the reference line, the most sensitive or painful point will be used as a reference. Participants with a negative (-) physical examination, that is, without the presence of MTrPs in the trapezius muscle shortened according to the protocol will be excluded, while those with a positive physical examination (+) will be able to participate in the study. The evaluation of muscle shortening and the presence of MTrPs will be carried out by a blind evaluator, who will record the laterality of the shortened muscle and the location distance of the MTrPs in a Microsoft Excel® spreadsheet, taking the spinous process of C7 as a reference.
The intervention phase will consist of 8 treatment sessions. The sample will be randomized into three study groups; group 1 (HILT + stretching exercises), group 2 (sham HILT + stretching exercises), and group 3 (conventional US + stretching exercises). All groups will receive as a basic treatment a therapeutic exercise plan of active static stretching of the upper trapezius muscle of 4 series for 30 seconds. The randomization of the sample will be carried out by the director of the study using the simple random sampling process through the research randomizer program (https://www.randomizer.org/). The results of the randomization will only be known by the director of the studio. Demographic variables for each group, including age, sex, and body mass index (BMI), will be tabulated in a Microsoft Excel® program spreadsheet.
Participants in each group will be evaluated by two independent examiners to determine cervical spine flexibility (CFROM) and pain intensity (PI), considered the main outcome measures of the study. The range of motion will be measured through goniometry, and the intensity of pain will be evaluated through algometry, establishing the painful pressure threshold (PPT). The PPT values will be evaluated in kg/cm2, while the CFROM will be evaluated in degrees. The PI and CFROM values will be tabulated in an Excel® spreadsheet for each evaluator.
6\. Statistic analysis
The descriptive statistics for the primary variables ΔCFROM, ΔPPT, and ΔNDI will use as analysis measures, means, and standard deviation (x, SD), or median and interquartile range (med, IQR) according to the normality analysis of the data. For secondary variables such as gender, body mass index (BMI), frequencies, and means or medians will be used, respectively, according to the normality analysis of the data.
For the inferential statistical analysis, the Shapiro Wilk (S-Wilk) normality test will be used to determine the distribution of the primary variables, and according to the results, parametric or non-parametric tests will be selected; One-way ANOVA if data are normally distributed or Kruskal Wallis test if variables are not normally distributed. For the statistical analysis, the STATA.v16 program will be used. Once the statistical analysis is done, a month will be considered for the review of the results, approach to the discussion, and conclusion.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Experimental group 1 (HILT + stretching exercise)
The group will receive treatment of high-intensity laser therapy (HILT) with a total energy delivery of 1,060J divided into 3 phases will be achieved: phase 1, 500J; phase 2, 60J; phase 3, 500J. It will work with an average power of 3W and an energy density of 50J/cm2. At the end of the assigned treatment will be added a treatment protocol of upper trapezius stretching exercises for the evaluated limb with shortening. The stretches will consist of 4 series of 30 seconds with an interval of 30 seconds between series.
High intensity laser therapy (HILT)
Laser application with powers greater than 500 milliwatts (mW) in the myofascial trigger point and muscle belly of the upper trapezius. Laser therapy will be applied to the upper trapezius muscle with a total energy delivery of 1,060J divided into 3 phases will be achieved (phase 1, 500J; phase 2, 60J; phase 3, 500J). It will work with an average power of 3W and an energy density of 50J/cm2. For the application of laser therapy, the 12W BTL-6000 equipment that emits infrared wavelengths of 1064nm will be used.
Stretching exercise
t the end of the assigned treatment will be added a treatment protocol of upper trapezius stretching exercises for the evaluated limb with shortening. The stretches will consist of 4 series of 30 seconds with an interval of 30 seconds between series
Experimental group 2 (Sham HILT + stretching exercise)
The group will receive a sham treatment of high-intensity laser therapy (HILT). At the end of the assigned treatment will be added a treatment protocol of upper trapezius stretching exercises for the evaluated limb with shortening. The stretches will consist of 4 series of 30 seconds with an interval of 30 seconds between series.
High intensity laser therapy (HILT)
Laser application with powers greater than 500 milliwatts (mW) in the myofascial trigger point and muscle belly of the upper trapezius. Laser therapy will be applied to the upper trapezius muscle with a total energy delivery of 1,060J divided into 3 phases will be achieved (phase 1, 500J; phase 2, 60J; phase 3, 500J). It will work with an average power of 3W and an energy density of 50J/cm2. For the application of laser therapy, the 12W BTL-6000 equipment that emits infrared wavelengths of 1064nm will be used.
Stretching exercise
t the end of the assigned treatment will be added a treatment protocol of upper trapezius stretching exercises for the evaluated limb with shortening. The stretches will consist of 4 series of 30 seconds with an interval of 30 seconds between series
Experimental group 3 (US + stretching exercise)
The group will receive treatment of therapeutic ultrasound. The US parameters will be programmed with a frequency of 1MHz, the intensity of 1.5 W/cm2, the Duty cycle of 100%, an ERA of 5cm2, and a time of 6 minutes. At the end of the assigned treatment will be added a treatment protocol of upper trapezius stretching exercises for the evaluated limb with shortening. The stretches will consist of 4 series of 30 seconds with an interval of 30 seconds between series.
Therapeutic Ultrasound (US)
Application of ultrasound therapy in the myofascial trigger point of the upper trapezius muscle. The ultrasound application will be performed with the person in a seated position. The ultrasound parameters will consist of a frequency of 1MHz, the intensity of 1.5 W/cm2, a Duty cycle of 100%, an ERA of 5cm2, and a treatment time of 6 minutes.
Stretching exercise
t the end of the assigned treatment will be added a treatment protocol of upper trapezius stretching exercises for the evaluated limb with shortening. The stretches will consist of 4 series of 30 seconds with an interval of 30 seconds between series
Interventions
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High intensity laser therapy (HILT)
Laser application with powers greater than 500 milliwatts (mW) in the myofascial trigger point and muscle belly of the upper trapezius. Laser therapy will be applied to the upper trapezius muscle with a total energy delivery of 1,060J divided into 3 phases will be achieved (phase 1, 500J; phase 2, 60J; phase 3, 500J). It will work with an average power of 3W and an energy density of 50J/cm2. For the application of laser therapy, the 12W BTL-6000 equipment that emits infrared wavelengths of 1064nm will be used.
Therapeutic Ultrasound (US)
Application of ultrasound therapy in the myofascial trigger point of the upper trapezius muscle. The ultrasound application will be performed with the person in a seated position. The ultrasound parameters will consist of a frequency of 1MHz, the intensity of 1.5 W/cm2, a Duty cycle of 100%, an ERA of 5cm2, and a treatment time of 6 minutes.
Stretching exercise
t the end of the assigned treatment will be added a treatment protocol of upper trapezius stretching exercises for the evaluated limb with shortening. The stretches will consist of 4 series of 30 seconds with an interval of 30 seconds between series
Eligibility Criteria
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Inclusion Criteria
* Officials and students of the Casona las Condes Campus of the Andrés Bello University.
* Presence of myofascial trigger points in the shortened upper trapezius muscle evaluated (expert consensus establishing criteria for the diagnosis of MTrPs, Delphi study).25
Exclusion Criteria
* Presence of osteosynthesis materials near shoulders, neck, or surrounding areas.
* Presence of wounds or skin changes in the shoulder and/or neck region (such as psoriasis, scars, or burns).
* Use of analgesic, anti-inflammatory, or muscle relaxant medications for permanent use.
* Neurological changes such as paresthesia, loss of sensitivity (partial or complete), decreased strength, and color changes in the neck, arms, forearms, or hands.
* Diagnosed photosensitivity.
* Presence of solar urticaria or adverse reactions to sunlight.
* Presence of the following conditions: dermatomyositis, systemic lupus erythematosus, hepatic porphyria, cutaneous carcinoid syndrome or pellagra
* Cancer or tumors of any type diagnosed.
* Epilepsy.
18 Years
ALL
Yes
Sponsors
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Quiropraxia y Equilibrio
OTHER
Responsible Party
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Principal Investigators
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Hernán A de la Barra Ortiz, Mg
Role: PRINCIPAL_INVESTIGATOR
Universidad Andrés Bello
Locations
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Universidad Andrés Bello
Santiago, Las Condes, Chile
Universidad Andrés Bello
Santiago, Santiago Metropolitan, Chile
Countries
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Central Contacts
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Facility Contacts
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References
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Espejo-Antunez L, Tejeda JF, Albornoz-Cabello M, Rodriguez-Mansilla J, de la Cruz-Torres B, Ribeiro F, Silva AG. Dry needling in the management of myofascial trigger points: A systematic review of randomized controlled trials. Complement Ther Med. 2017 Aug;33:46-57. doi: 10.1016/j.ctim.2017.06.003. Epub 2017 Jun 15.
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Knapstad MK, Nordahl SHG, Naterstad IF, Ask T, Skouen JS, Goplen FK. Measuring pressure pain threshold in the cervical region of dizzy patients-The reliability of a pressure algometer. Physiother Res Int. 2018 Oct;23(4):e1736. doi: 10.1002/pri.1736. Epub 2018 Aug 7.
Hanney WJ, Puentedura EJ, Kolber MJ, Liu X, Pabian PS, Cheatham SW. The immediate effects of manual stretching and cervicothoracic junction manipulation on cervical range of motion and upper trapezius pressure pain thresholds. J Back Musculoskelet Rehabil. 2017 Sep 22;30(5):1005-1013. doi: 10.3233/BMR-169573.
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Related Links
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BTL Company
Other Identifiers
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60312070
Identifier Type: -
Identifier Source: org_study_id
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