The Predictive Role of Self-representation in Transition of Individuals at Clinical High Risk for Psychosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-07-06

Study Completion Date

2021-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Schizophrenia is one of the most consumptive diseases, which brings great loss to patients and their families, and even to the society. Clinical High Risk for Psychosis (CHR) is a concept put forward on the basis of the prodromal stage of schizophrenia. Over the past 20 years, the identification and intervention of CHR has become the focus of psychiatric research, with the primary goal of early identification of biomarkers of susceptibility to schizophrenia and the development of individualized interventions to prevent or delay progression. Longitudinal studies have shown that CHR converted to schizophrenia mainly within two years, with a risk of about 30 percent. Self-disorder is one of the core characteristics of schizophrenia. The two most basic experiences of self-representation are sense of ownership and sense of agency. Sense of ownership refers to the sense that "I" perceives "my" body, while sense of agency refers to the sense that "I" experiences "my" actions and their consequences are initiated by "me". Some studies have shown that patients with schizophrenia show defects in the sense of ownership and agency. The most commonly used paradigm for observing "sense of ownership" and "sense of agency" is the rubber hand illusion (RHI) or the virtual hand illusion (VHI). In this study, the VHI experimental paradigm will be used to detect the self-representation of the individuals at high risk for psychosis, and the clinical outcome will be observed for one year.The hypothesis is that the subjects who exhibit abnormal illusion experience in VHI experiment are more likely to transition into psychotic disorders.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Cognitive and Emotional Factors in Visual Exploration Among Patients With Schizophrenia

NCT02874482

Schizophrenia

COMPLETED

Mechanisms of Response to Therapeutic Intervention in Clinical High Risk (CHR) for Psychosis

NCT06542640

Psychosis; Schizophrenia-Like Healthy Controls

RECRUITING NA

Brain Imaging, Attention, and Auditory Processing in Schizophrenia

NCT03068806

Schizophrenia

COMPLETED

Perception of Facial Emotions in Schizophrenia and 22q11 Deletion Syndrome

NCT02634671

Schizophrenia

COMPLETED NA

"Manual Dexterity and Oculomotor Control in Schizophrenia"

NCT02826629

Schizophrenia

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study is conducted according to the tenets of the Declaration of Helsinki. All participants are recruited at the Shanghai Mental Health Center (SMHC) or its affiliate, the Shanghai Psychotherapy and Psychological Counseling Center (SPCC) with written informed consent, approved by the Research Ethics Committee of SMHC. For those younger than 18 years, both the adolescents and their next of kin or legal guardians are provided informed consents. The outpatients are recommended by doctors to participate in our CHR screening. After being screened and interviewed, those who meet the inclusion criteria are informed and signed written informed consent. Once the subjects are recruited, clinical evaluation, VHI and MCCB test will be conducted. In addition, CHR individuals will be followed up at one-year node.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Clinical High Risk for Psychosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Clinical high risk for psychosis (CHR)

No intervention. Just use virtual hand illusion (VHI) paradigm to observe the outcome of individuals with CHR at one-year follow-up node and analyze the predictive role of self-representation in transition into psychosis.

Virtual hand illusion (VHI)

Intervention Type DIAGNOSTIC_TEST

Using VHI, the two basic self-representation of sense of ownership and sense of agency of the subjects will be observed.

First episode of schizophrenia (FES)

In contrast to FES, it is anticipated to observe CHR individuals with similar behavioral performance to FES may presented higher risk of transition.

Virtual hand illusion (VHI)

Intervention Type DIAGNOSTIC_TEST

Using VHI, the two basic self-representation of sense of ownership and sense of agency of the subjects will be observed.

Healthy control (HC)

In contrast to HC, it is anticipated to observe CHR individuals with similar behavioral performance to HC may presented lower risk of transition.

Virtual hand illusion (VHI)

Intervention Type DIAGNOSTIC_TEST

Using VHI, the two basic self-representation of sense of ownership and sense of agency of the subjects will be observed.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Virtual hand illusion (VHI)

Using VHI, the two basic self-representation of sense of ownership and sense of agency of the subjects will be observed.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* For CHR individuals, meet the criteria of psychosis-risk syndromes after rating by structured interview for psychosis high risk syndrome.
* For FES patients, meet diagnostic criteria for schizophrenia in the DSM-IV.
* For HC individuals, gender composition, age range, educational level are matched with CHR individuals.
* Understand and sign written informed consent.

Exclusion Criteria

* For CHR individuals, exclude individuals with other axis I or II mental disorders, which can explain the abnormal experience.
* For CHR and FES patients, exclude those patients taking antipsychotics for more than two weeks.
* For HC individuals, exclude those with family history of mental disorders
* With a history of substance dependence.
* Use of medications that may affect mental and cognitive functions.
* With central nervous system disorder, that cuase symptoms or interfere with judgment.
* Traumatic brain injury score is 7 or more.
* With serious or unstable physical diseases.
* With perceptual developmental disorders.
* IQ\<70.

Minimum Eligible Age

11 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes