Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.
NCT ID: NCT04432883
Last Updated: 2025-05-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
50 participants
INTERVENTIONAL
2022-10-18
2027-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Experimental: Active cathodal tDCS + Speech-language training
In this arm, 31 patients with stroke induced Aphasia will undergo 15 sessions of active tDCS (x 30 minutes of stimulation) combined with 1 hour simultaneous speech-language training on consecutive weekdays.
Active Comparator: Experimental: Active cathodal tDCS + language training
Cathodal tDCS raises neuronal membrane potentials, leading to decreased probability of depolarization from incoming stimuli.
Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment.
Comparator: Placebo cathodal tDCS + Speech-language training
In this arm, 31 patients with stroke induced Aphasia will undergo 15 sessions of sham tDCS (x 30 minutes sham) combined with 1 hour simultaneous speech-language training on consecutive weekdays..
Sham Comparator: Placebo cathodal tDCS + Speech and language
Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment. .
Interventions
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Active Comparator: Experimental: Active cathodal tDCS + language training
Cathodal tDCS raises neuronal membrane potentials, leading to decreased probability of depolarization from incoming stimuli.
Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment.
Sham Comparator: Placebo cathodal tDCS + Speech and language
Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment. .
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. must be greater than 6 months post-stroke
3. must have a diagnosis of aphasia based on impaired performance on the Western Aphasia Battery-Revised, Boston Naming Test, or during discourse production
4. must be left-hemisphere dominant as demonstrated by aphasia onset subsequent to left hemisphere damage
5. must be stimulable for naming
Exclusion Criteria
2. damage to the anterior right hemisphere.
3. significant mood disorder.
4. substance/alcohol dependence or abuse within the past year
5. presence of any implanted electrical device or contraindications to tDCS or MRI
6. recent medical instability (within 4 weeks)
7. pregnancy
25 Years
85 Years
ALL
No
Sponsors
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National Institutes of Health (NIH)
NIH
National Institute of General Medical Sciences (NIGMS)
NIH
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
University of New Mexico
OTHER
Responsible Party
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Jessica Richardson
Assistant Professor: SOM Neurosurgery
Principal Investigators
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Jessica Richardson, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of New Mexico
Locations
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University of New Mexico Center for Brain Recovery and Repair
Albuquerque, New Mexico, United States
Countries
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Central Contacts
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Facility Contacts
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Provided Documents
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Document Type: Informed Consent Form
Other Identifiers
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