Effect of Platelet-rich Plasm (PRF) on Two-implant Mandibular Overdenture: a Split Mouth
NCT ID: NCT04429373
Last Updated: 2021-04-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
NA
40 participants
INTERVENTIONAL
2020-11-30
2022-12-20
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Platelet-rich fibrin (PRF) is a blood derivate that can be easily and economically obtained from patients and that has shown promise of reducing the complications and improving the success of implant therapy, nevertheless its benefits in patients receiving implant retained overdentures has not been stablished. It is possible that PRF can improve the results and diminish the complications of implant therapy in older adults.
The investigation aims to demonstrate that the use of platelet-rich fibirn (PRF) is safe and beneficial for implant treatment in older adults suffering from complete tooth loss.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Randomized Study For Minimally Invasive Splinted Implants
NCT02107612
Immediate Dental Prosthesis Functionalization Protocol in People Over 70 Years of Age
NCT05818436
Evaluation of Dental Implants Placed in Preserved and Non-preserved Post-extraction Ridges
NCT03715439
Application of a Simplified Method of Complete Denture Fabrication for Severely Resorbed Mandibular Ridges
NCT02339194
Mandibular Overdentures Retained by Conventional or Mini Implants
NCT01411683
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Aim and purpose
1. To assess the effect of PRF on primary implant stability of mandibular implants in edentulous patients using resonance frequency analysis (RFA).
2. To evaluate the effect of PRF on clinical parameters related to soft tissue healing, post-surgical pain/inflammation and early complications of mandibular implants in edentulous patients.
3. To examine soft tissues volumetric changes pre and post- surgery using intraoral scans and bone changes using cone-beam computed tomography (CBCT) around mandibular implants in edentulous patients.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Implant installation with PRF
PRF membrane over the buccal aspect of implant site
Implant installation with PRF membrane
Platelet-rich fibrin membrane over the buccal aspect of implant site after dental implant installation
Implant installation without PRF
Implant installation contralateral to the the experimental implant, without PRF membrane
Implant installation without PRF membrane
Implant installation contralateral to the experimental side without PRF membrane
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Implant installation with PRF membrane
Platelet-rich fibrin membrane over the buccal aspect of implant site after dental implant installation
Implant installation without PRF membrane
Implant installation contralateral to the experimental side without PRF membrane
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* \> 60 years old
Exclusion Criteria
* dental extraction \< 6 months in the mandible
* anticoagulant treatment
60 Years
100 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University of Chile
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Franco Cavalla
Assistant Professor
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
San Camilo Hospital
San Felipe, Aconcagua, Chile
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
ORF42004
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.