Assesment of Multiomics Profiles in Health and Disease.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-09-01

Study Completion Date

2029-03-30

Brief Summary

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This study will determine reference genomic, transcriptomic, proteomic and metabolomic profiles in Czech population and will evaluate its correlation with the disease phenotype.

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Detailed Description

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This study will determine reference genomic, transcriptomic, proteomic and metabolomic profiles in Czech population. Initially, there will be 1000 healthy volunteers, with the planned expansion to 10.000 participants (healthy volunteers and patients with different types of disease). Formation of the reference database of healthy volunteers and their parameters will allow a correct interpretation of the potential pathological findings in patients. It is very important to obtain healthy controls from the region of the Czech Republic, Central Europe respectively; since it is not possible to reliably compere ethnically and geographically diverse populations, which have generated in a different context and where the diseases manifest with other etiology ad phenotype. Although, in the limited measure, the similar molecular data exist in foreign databases, these are not compiled from the inhabitants of the Czech Republic, Central Europe not even from Slavic population. Study participants may volunteer for archiving of remaining biological materials for future studies.

Conditions

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Genetic Predisposition to Disease

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Genomic, transcriptomic, proteomic, metabolomic profiles

Determination of genomic, transcriptomic, proteomic, metabolomic profiles in subjects.

Blood sample analysis

Intervention Type GENETIC

Nucleic acids sequencing, presence of proteins and metabolites.

Health status

Intervention Type OTHER

Health status will be examined by a physician and subject will complete a health status questionnaire.

Race and ethnicity

Intervention Type OTHER

Subject will complete race and ethnicity questionnaire to make sure subjects are from the Czech population.

Interventions

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Blood sample analysis

Nucleic acids sequencing, presence of proteins and metabolites.

Intervention Type GENETIC

Health status

Health status will be examined by a physician and subject will complete a health status questionnaire.

Intervention Type OTHER

Race and ethnicity

Subject will complete race and ethnicity questionnaire to make sure subjects are from the Czech population.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age 18 - 68 years
* (for the first 1100 subjects):
* healthy volunteers without genetically dependent disease and without such a disease in a family
* healthy volunteer without the preliminary evidence of civilizational diseases such as hypertension, diabetes, autoimmune and tumor diseases or acute infectional diseases; clinically manifesting cardiovascular or pulmonary disability.
* subject without permanent of long-term medication in the time of biological sampling.

Minimum Eligible Age

18 Years

Maximum Eligible Age

68 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes