Human Phenotype Project Study Protocol

NCT ID: NCT05817734

Last Updated: 2024-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-01

Study Completion Date

2045-12-31

Brief Summary

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This is a prospective study aimed at recruiting 30,000 individuals, aged 40-70 years old, and following them longitudinally for 25 years with repeated measurements. The basic follow-up frame will include a visit to the Clinical Test Center (CTC) every two years and a phone interview every other year (on uneven years). Sample collection and biobanking will be performed every two years and online questionnaires will be filled out on an annual basis.

The primary goals are to study the variation observed across different individuals in disease susceptibility, clinical phenotypes, and therapeutic responses. The study aims at studying the complex interplay and relative contribution of different omics, physiological characteristics and lifestyle on disease pathogenesis and progression and to evaluate how these effects are mediated.

Detailed Description

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Conditions

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Adult Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Ages 18+, males and females.

Exclusion Criteria

* Pregnancy.
* Mentally disabled or in general legally non-competent.
* Prisoner or soldier. Soldiers: mandatory service only
* Active cancer
* Fertility Treatments (current)
* Hepatitis ( B, C), chronic or acute
* HIV
* Liver cirrhosis
* Dialysis
* Unstable medical conditions
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Weizmann Institute of Science

OTHER

Sponsor Role lead

Responsible Party

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Eran Segal

Prof. Eran Segal, PI at the department of computer science and applied math

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Weizmann institute of science

Rehovot, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Eran Segal, Prof.

Role: CONTACT

972-8-9343266

Facility Contacts

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Hila Saranga, Msc

Role: primary

972-8-9343266

References

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Rein M, Elkan M, Godneva A, Dolev NC, Segal E. Sex-specific dietary habits and their association with weight change in healthy adults. BMC Med. 2024 Nov 6;22(1):512. doi: 10.1186/s12916-024-03730-3.

Reference Type DERIVED
PMID: 39501340 (View on PubMed)

Other Identifiers

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1789-1

Identifier Type: -

Identifier Source: org_study_id

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