Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
2000 participants
OBSERVATIONAL
1998-07-31
2032-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Probands
Ashkenazi Jews ages 95 and older
No interventions assigned to this group
Offspring
Ashkenazi Jewish offspring of Ashkenazi Jewish parent(s) who lived to at least the age of 95
No interventions assigned to this group
Controls
Ashkenazi Jewish people with no family history of longevity
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Offspring of person age 95+,
* Offspring of parents who died age 70 or younger.
Exclusion Criteria
65 Years
ALL
Yes
Sponsors
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Rutgers Health
UNKNOWN
University of Rochester
OTHER
National Institute on Aging (NIA)
NIH
American Federation for Aging Research
OTHER
Weill Medical College of Cornell University
OTHER
Boston University
OTHER
Regeneron Pharmaceuticals
INDUSTRY
Harvard Medical School (HMS and HSDM)
OTHER
Stanford University
OTHER
Tufts Medical Center
OTHER
Columbia University
OTHER
University of Minnesota
OTHER
Albert Einstein College of Medicine
OTHER
Responsible Party
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Principal Investigators
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Nir Barzilai, MD
Role: PRINCIPAL_INVESTIGATOR
Albert Einstein College of Medicine
Locations
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Private Homes
New York, New York, United States
Hebrew Home Riverdale
Riverdale, New York, United States
Countries
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Central Contacts
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Facility Contacts
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Charlotte Dell, LMSW
Role: primary
References
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DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 Jan;1507(1):70-83. doi: 10.1111/nyas.14681. Epub 2021 Sep 8.
Moqri M, Herzog C, Poganik JR; Biomarkers of Aging Consortium; Justice J, Belsky DW, Higgins-Chen A, Moskalev A, Fuellen G, Cohen AA, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han JJ, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy BK, Ferrucci L, Horvath S, Verdin E, Maier AB, Snyder MP, Sebastiano V, Gladyshev VN. Biomarkers of aging for the identification and evaluation of longevity interventions. Cell. 2023 Aug 31;186(18):3758-3775. doi: 10.1016/j.cell.2023.08.003.
Moqri M, Herzog C, Poganik JR, Ying K, Justice JN, Belsky DW, Higgins-Chen AT, Chen BH, Cohen AA, Fuellen G, Hagg S, Marioni RE, Widschwendter M, Fortney K, Fedichev PO, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel DP, Kennedy BK, Cummings S, Slagboom PE, Verdin E, Maier AB, Sebastiano V, Snyder MP, Gladyshev VN, Horvath S, Ferrucci L. Validation of biomarkers of aging. Nat Med. 2024 Feb;30(2):360-372. doi: 10.1038/s41591-023-02784-9. Epub 2024 Feb 14.
Bae H, Song Z, Ali A, Sasaki T, Tesi N, Lords H, Leshchyk A, Abe Y, Hirose N, Arai Y, Barzilai N, Weiss EF, Hulsman M, van der Lee S, van Schoor NM, Huisman M, Pijnenburg Y, van der Flier W, Reinders M, Holstege H, Milman S, Perls TT, Andersen SL, Sebastiani P. Increased genetic protection against Alzheimer's disease in centenarians. Geroscience. 2025 Jul 4. doi: 10.1007/s11357-025-01774-8. Online ahead of print.
Ali A, Zhang ZD, Gao T, Aleksic S, Gavathiotis E, Barzilai N, Milman S. Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity. Sci Rep. 2025 Mar 25;15(1):10199. doi: 10.1038/s41598-025-94094-y.
Ying K, Castro JP, Shindyapina AV, Tyshkovskiy A, Moqri M, Goeminne LJE, Milman S, Zhang ZD, Barzilai N, Gladyshev VN. Depletion of loss-of-function germline mutations in centenarians reveals longevity genes. Nat Commun. 2024 Oct 19;15(1):9030. doi: 10.1038/s41467-024-52967-2.
Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D, Bergman A. Genetic studies reveal the role of the endocrine and metabolic systems in aging. J Clin Endocrinol Metab. 2010 Oct;95(10):4493-500. doi: 10.1210/jc.2010-0859.
Other Identifiers
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G42988
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
1998-125
Identifier Type: -
Identifier Source: org_study_id
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