The Longevity Genes in Founder Populations Project

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

1998-07-31

Study Completion Date

2032-12-31

Brief Summary

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We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of our research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.

Detailed Description

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Conditions

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Extreme Longevity

Keywords

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95 years of age and older

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Probands

Ashkenazi Jews ages 95 and older

No interventions assigned to this group

Offspring

Ashkenazi Jewish offspring of Ashkenazi Jewish parent(s) who lived to at least the age of 95

No interventions assigned to this group

Controls

Ashkenazi Jewish people with no family history of longevity

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Ashkenazi Jewish, age 95+,
* Offspring of person age 95+,
* Offspring of parents who died age 70 or younger.

Exclusion Criteria

* Non-Ashkenazis

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nir Barzilai, MD

Role: PRINCIPAL_INVESTIGATOR

Albert Einstein College of Medicine

Locations

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Private Homes

New York, New York, United States

Site Status RECRUITING

Hebrew Home Riverdale

Riverdale, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Deborah Davidson, MBA

Role: CONTACT

Phone: 718-430-3237

Email: [email protected]

Facility Contacts

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Wanda I Guzman, BA

Role: primary

Charlotte Dell, LMSW

Role: primary

References

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DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 Jan;1507(1):70-83. doi: 10.1111/nyas.14681. Epub 2021 Sep 8.

Reference Type RESULT

PMID: 34498278 (View on PubMed)

Moqri M, Herzog C, Poganik JR; Biomarkers of Aging Consortium; Justice J, Belsky DW, Higgins-Chen A, Moskalev A, Fuellen G, Cohen AA, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han JJ, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy BK, Ferrucci L, Horvath S, Verdin E, Maier AB, Snyder MP, Sebastiano V, Gladyshev VN. Biomarkers of aging for the identification and evaluation of longevity interventions. Cell. 2023 Aug 31;186(18):3758-3775. doi: 10.1016/j.cell.2023.08.003.

Reference Type RESULT

PMID: 37657418 (View on PubMed)

Moqri M, Herzog C, Poganik JR, Ying K, Justice JN, Belsky DW, Higgins-Chen AT, Chen BH, Cohen AA, Fuellen G, Hagg S, Marioni RE, Widschwendter M, Fortney K, Fedichev PO, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel DP, Kennedy BK, Cummings S, Slagboom PE, Verdin E, Maier AB, Sebastiano V, Snyder MP, Gladyshev VN, Horvath S, Ferrucci L. Validation of biomarkers of aging. Nat Med. 2024 Feb;30(2):360-372. doi: 10.1038/s41591-023-02784-9. Epub 2024 Feb 14.

Reference Type RESULT

PMID: 38355974 (View on PubMed)

Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D, Bergman A. Genetic studies reveal the role of the endocrine and metabolic systems in aging. J Clin Endocrinol Metab. 2010 Oct;95(10):4493-500. doi: 10.1210/jc.2010-0859.

Reference Type DERIVED

PMID: 20926537 (View on PubMed)