Study Results
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Basic Information
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COMPLETED
500 participants
OBSERVATIONAL
2020-01-30
2020-06-01
Brief Summary
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Although the hypersensitivity reactions to cephalosporins have been recently a more focused subject, studies on the cephalosporin as an allergen are significantly less frequent that those regarding penicillins. Most of the available data regards cephalosporin sensitization in patients previously allergic to penicillin. Like penicillins, cephalosporins represent one of the most prescribed classes of antibiotics. The diagnosis of cephalosporin hypersensitivity is based mainly on clinical history, skin tests (ST) and drug provocation tests (DPT). This succession of tests, performed in specialized services, allows to eliminate responsibility for the drug in many cases (80-85%). The drug allergy work-up also allows to identify profiles of allergy to cephalosporins, with different patterns of cross-reactivity.
Objective: To analyse the characteristics of patients studied in our Unit for suspicion of cephalosporin hypersensitivity.
Methods: This retrospective study will comprise all the patients who attended the allergy service of the UH of Montpellier from 1997 till 2018 with a clinical history evocative of cephalosporin drug hypersensitivity reaction (DHR), who underwent a drug allergy work up and who gave their consent to be included in the study . The Patients are selected from the Drug Allergy \& Hypersensitivity Database (DAHD).
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
10 Years
ALL
No
Sponsors
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University Hospital, Montpellier
OTHER
Responsible Party
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Principal Investigators
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Anca Chiriac, MD,PhD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Montpellier
Locations
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Uhmontpellier
Montpellier, , France
Countries
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Other Identifiers
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RECHMPL20_0021
Identifier Type: -
Identifier Source: org_study_id
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