DEB vs Thin-DES in DES-ISR: Long Term Outcomes (DEB Dragon Registry)

NCT ID: NCT04415216

Last Updated: 2021-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1369 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-10

Study Completion Date

2020-03-01

Brief Summary

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Data regarding the usefulness of percutaneous coronary intervention (PCI) with drug eluting balloon (DEB) vs. thin struts drug eluting stents (thin-DES) for treating in-stent restenosis (ISR) in every day clinical practice is scarce. We aimed to evaluate comparing the efficacy and safety profile of DEB and thin-DES in DES-ISR.

Detailed Description

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Conditions

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In Stent Restenosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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ISR PCI with thin-DES

percutaneous coronary intervention

Intervention Type DEVICE

Percutaneous coronary intervention with drug eluting balloon (DEB) vs. thin struts drug eluting stents (thin-DES) for treating in-stent restenosis (ISR)

ISR PCI with DEB

percutaneous coronary intervention

Intervention Type DEVICE

Percutaneous coronary intervention with drug eluting balloon (DEB) vs. thin struts drug eluting stents (thin-DES) for treating in-stent restenosis (ISR)

Interventions

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percutaneous coronary intervention

Percutaneous coronary intervention with drug eluting balloon (DEB) vs. thin struts drug eluting stents (thin-DES) for treating in-stent restenosis (ISR)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

• All consecutive patients with DES-ISR who were treated with either paclitaxel-DEB or thin-DES.

Exclusion Criteria

* PCI with DES struts thickness \>100μm
* PCI with DEB and thin-DES in the same procedure
* PCI of other vascular territories during the same procedure
* PCI in saphenous vain graft or internal mammary artery
Eligible Sex

Accepts Healthy Volunteers

No

Sponsors

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Wojciech Wojakowski

UNKNOWN

Sponsor Role collaborator

Medical University of Silesia

OTHER

Sponsor Role lead

Responsible Party

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Wojciech Wańha

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Invasive Cardiology, Medical University of Bialystok

Bialystok, , Poland

Site Status

Cardiovascular Institute, Nicolaus Copernicus University, Bydgoszcz, Poland

Bydgoszcz, , Poland

Site Status

First Department of Cardiology, Medical University of Gdansk, Gdansk, Poland

Gdansk, , Poland

Site Status

Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland

Katowice, , Poland

Site Status

Second Department of Cardiology, Jagiellonian University Medical College, Krakow, Poland

Krakow, , Poland

Site Status

Department of Interventional Cardiology and Angiology, National Institute of Cardiology, Warsaw, Poland

Warsaw, , Poland

Site Status

Department of Invasive Cardiology, Centre of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of Interior and Administration

Warsaw, , Poland

Site Status

Centre for Heart Disease, University Hospital Wroclaw Department of Heart Disease, Wroclaw Medical University

Wroclaw, , Poland

Site Status

Third Department of Cardiology, Medical University of Katowice

Zabrze, , Poland

Site Status

Countries

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Poland

References

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De Filippo O, Wanha W, Sanavia T, Januszek R, Giacobbe F, Campo G, Pinxterhuis TH, Capodanno D, Tomasiewicz B, Iannaccone M, Leone A, Wolny R, Bruno F, Patti G, Musumeci G, Liccardo G, Verardi R, Roubin SR, Tarantini G, Kuzma L, Perl L, Gagnor A, Reczuch K, Conrotto F, Tuttolomondo D, Ploumen EH, Niezgoda P, Caglioni S, Omede P, Greco A, Kubica J, Gil RJ, Piccolo R, Kornowski R, Bil J, Morena A, Zocca P, Pennone M, Gasior M, Jaguszewski M, von Birgelen C, Fariselli P, De Ferrari GM, Wojakowski W, D'Ascenzo F. Treatment of in-stent restenosis with ultrathin-strut versus thin-strut drug-eluting stents or drug-eluting balloons: a multicentre registry. EuroIntervention. 2024 Nov 4;20(21):e1340-e1354. doi: 10.4244/EIJ-D-24-00491.

Reference Type DERIVED
PMID: 39492702 (View on PubMed)

Wanha W, Bil J, Januszek R, Gilis-Malinowska N, Figatowski T, Milewski M, Pawlik A, Staszczak B, Wybraniec M, Tomasiewicz B, Kubler P, Kuliczkowski W, Walczak T, Hrymniak B, Desperak P, Mielczarek M, Ciecwierz D, Niezgoda P, Wolny R, Chudzik M, Kuzma L, Kralisz P, Kedhi E, D'Ascenzo F, Hudziak D, Kowalowka A, Smolka G, Reczuch K, Gruchala M, Kubica J, Gil RJ, Dobrzycki S, Dudek D, Bartus S, Gasior M, Ochala A, Witkowski A, Jaguszewski M, Wojakowski W. Long-Term Outcomes Following Drug-Eluting Balloons Versus Thin-Strut Drug-Eluting Stents for Treatment of In-Stent Restenosis (DEB-Dragon-Registry). Circ Cardiovasc Interv. 2021 Sep;14(9):e010868. doi: 10.1161/CIRCINTERVENTIONS.121.010868. Epub 2021 Sep 3.

Reference Type DERIVED
PMID: 34474584 (View on PubMed)

Other Identifiers

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02

Identifier Type: -

Identifier Source: org_study_id

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