Microvascular Flow and Reactivity in Patients Presenting in the Acute Phase of COVID-19.
NCT ID: NCT04406545
Last Updated: 2022-01-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
25 participants
OBSERVATIONAL
2020-05-15
2022-01-10
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
The Association Between Systemic Microvascular Endothelial Function and Coronary Physiology Indexes
NCT05864729
Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis
NCT02940340
Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries
NCT06446895
The Evolution of Systemic Microvascular Reactivity in Heart Transplant Patients
NCT05729009
Prognostic and Clinical Impact of Cardiovascular Involvement in Patients With COVID-19
NCT04624503
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
As an initial process, the SARS-CoV-2 virus, anchored in the transmembrane angiotensin-converting enzyme 2 (ECA2), penetrates host cells, including endothelial cells, pericytes and macrophages, in addition to type II pneumocytes.
Cellular invasion results in massive release of several pro-inflammatory cytokines ("cytokine storm"), such as IL-1β, IFN-1 and IL-6, by the cells of the immune system. In turn, cytokines increase the process of vascular inflammation and the expression of leukocyte-vascular endothelium adhesion proteins, which results in endothelial activation accompanied by a pro-coagulant and pro-adhesive phenotype - between leukocytes, platelets, red blood cells and vascular endothelium - characteristic of the dysfunctional endothelium in the microcirculation, which results in severe changes in the microvascular flow and, as a result, in tissue perfusion.
It is also worth noting that the patients most vulnerable to the development of complications are those with pre-existing endothelial dysfunction, associated with several risk factors such as male gender and smoking, and comorbidities such as hypertension, diabetes and obesity, all of which are associated with poor prognosis in COVID -19.
Considering that the intensity of systemic microvascular changes in patients in the acute phase of COVID-19 could be related to disease progression and prognosis, the present cross-sectional and observational study aims to investigate the presence of endothelial dysfunction in these patients, also evaluating associations between the presence of endothelial dysfunction and demographic, clinical and laboratory variables.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
COHORT
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
healthy volunteers
skin laser Doppler perfusion monitoring before and after local thermal hyperemia
evaluation of skin microvascular flow and reactivity
evaluation of skin microvascular flow and reactivity using laser Doppler perfusion monitoring
cardiovascular disease and COVID-19 infection
skin laser Doppler perfusion monitoring before and after local thermal hyperemia
evaluation of skin microvascular flow and reactivity
evaluation of skin microvascular flow and reactivity using laser Doppler perfusion monitoring
cardiovascular disease without COVID-19 infection
skin laser Doppler perfusion monitoring before and after local thermal hyperemia
No interventions assigned to this group
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
evaluation of skin microvascular flow and reactivity
evaluation of skin microvascular flow and reactivity using laser Doppler perfusion monitoring
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Exclusion Criteria
18 Years
80 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
National Institute of Cardiology, Laranjeiras, Brazil
OTHER_GOV
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Eduardo Tibirica, MD, PhD
Senior Researcher
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
National Institute of Cardiology
Rio de Janeiro, , Brazil
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
#CAAE 31237220.1.0000.5272
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.