Coronary Hemodynamics by Coronary Angiography

NCT ID: NCT04646278

Last Updated: 2020-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-11

Study Completion Date

2020-03-25

Brief Summary

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Study for developing techniques to evaluate coronary artery hemodynamic profiles by conventional angiography without more dedicated measuring devices.

Detailed Description

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\* Methods: Compare TIMI frame count, coronary clearance frame count in baseline/hyperemic coronary angiography with FFR, CFR, IMR and derive correlation, receiver-operating characteristic curve to find new tools estimating coronary hemodynamics by conventional angiography only.

A TIMI frame count is measured by counting the angiographic image cine frames during a head of radiocontrast column runs from the entry of left anterior descending artery (LAD) to the distal end.

A coronary clearance frame count is measured by counting the angiographic image cine frames during a tail of radiocontrast column runs from the entry of LAD to the distal end.

Baseline angiography is performed without any stimulation and hyperemic angiography is performed after intracoronary injection of adenosine 300ug or nicorandiol 2mg.

Inclusion criteria

* Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography

Exclusion criteria

* ST elevation myocardial infarction
* Cardiogenic shock
* Congestive heart failure with pulmonary edema
* LVEF \< 30%
* Previous history of coronary revascularization
* Chronic total occlusion
* 3 vessel disease
* Target lesion at distal segments or branches

Conditions

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Coronary Artery Disease

Keywords

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coronary artery disease Index of microcirculatory resistance TIMI frame count Fractional flow reserve Coronary flow reserve

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Patients who underwent coronary angiography and further hyperemic stimui
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Hyperemic stimuli

Hyperemic stimuli of coronary flow by adenosine or nicorandil injection

Group Type EXPERIMENTAL

Hyperemic stimuli

Intervention Type DRUG

Hyperemic simuli of coronary flow by adenosine or nicorandil injection

Interventions

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Hyperemic stimuli

Hyperemic simuli of coronary flow by adenosine or nicorandil injection

Intervention Type DRUG

Other Intervention Names

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Hyperemia

Eligibility Criteria

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Inclusion Criteria

* Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography

Exclusion Criteria

* ST elevation myocardial infarction
* Cardiogenic shock
* Congestive heart failure with pulmonary edema
* LVEF \< 30%
* Previous history of coronary revascularization
* Chronic total occlusion
* 3 vessel disease
* Target lesion at distal segments or branches
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Korean Society of Cardiology

OTHER

Sponsor Role collaborator

KangWon National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bong-Ki Lee, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

KangWon National University Hospital

Locations

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Kangwon National University Hospital

Chuncheon, Gangwon-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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B-2017-01-012-015

Identifier Type: -

Identifier Source: org_study_id