Oral Health Status in Patients With Cirrhosis and Effect of Dental Treatment on MELD Score of Cirrhosis Patients

NCT ID: NCT04399512

Last Updated: 2020-05-22

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 110 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-01-01
• Study Completion Date: 2021-06-30

Brief Summary

It has been found that there is an association between prevalence of odontogenic infection and systemic diseases.Cirrhosis has also been associated with poor oral health status.Treating those patients accordingly can help in reducing the source of infection to some extent and may be associated with reduction in mortality.

Detailed Description

Patients will be selected according to inclusion and exclusion criteria.Written informed consent will be taken from each participant after being informed about study .There will be two groups1) cirrhosis patients 2)normal healthy patients.Prevalence of apical periodontitis will be measured in both groups by intraoral examination,digital panoramic radiography.. MELD score will be recorded in cirrhosis patients at this stage.Non surgical root canal treatment will be performed in teeth with apical periodontitis. Periapical healing will be checked with the help of PAI Score given by Orstavik. In Cirrhosis patients MELD Score will be measured before and after treatment.

Conditions

Liver Cirrhosis; Periapical Lesions

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Patients with liver cirrhosis

prevalence of apical periodontitis will be checked and non-surgical root canal treatment will be given to the patients with apical periodontitis and change in MELD(model for end stage liver disease) will be checked after treatment.

Group Type: ACTIVE_COMPARATOR

Nonsurgical root canal treatment

Intervention Type: PROCEDURE

Nonsurgical root canal treatment will be given

Normal healthy patients

prevalence of apical periodontitis will be checked and non-surgical root canal treatment will be given to the patients with apical periodontitis

Group Type: ACTIVE_COMPARATOR

Nonsurgical root canal treatment

Intervention Type: PROCEDURE

Nonsurgical root canal treatment will be given

Interventions

Nonsurgical root canal treatment

Nonsurgical root canal treatment will be given

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Known patient of cirrhosis(Diagnosis of cirrhosis is based on blood testing, medical imaging, and liver biopsy.) with mature permanent teeth .

2. Age35-55 years

3. > or equal to 8 natural teeth(excluding 3rd molars);

4. I.N.R < 3.5

-

Exclusion Criteria

1. Patient having systemic disorders other than hepatic disease(e.g. HIV, osteoporosis,diabetes,cardiovascular disease)

2. Pregnancy

3. Use of systemic and topical antibiotic treatment within 3 months prior to the start of the study.

The eligibility criteria of the control group were the same for the cirrhosis group, except for the presence of liver disease. Cirrhosis patients were matched with controls according to sex, age (± 3 years old) and current smoking status and alcohol satus (yes/no).

-

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Postgraduate Institute of Dental Sciences Rohtak

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Post Graduate Institute of Dental Sciences

Rohtak, Haryana, India

Site Status: RECRUITING

Countries

India

Central Contacts

Swati Sharma

Role: CONTACT

sharma.swati18787@gmail.com

8199925698

Other Identifiers

swatiendo18787

Identifier Type: -

Identifier Source: org_study_id