Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE4
9000 participants
INTERVENTIONAL
2020-07-30
2026-12-31
Brief Summary
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Detailed Description
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The study will be conducted using the existing platform of the Chinese peritoneal dialysis (PD) and hemodialysis (HD) Dialysis Registry to screen, recruit and to collect study data as part of patient's routine clinical care during dialysis to improve efficiency and to minimize cost of a clinical trial.
ASPIRED is an event driven trial with an anticipated duration of approximately 5 years.
Randomization will be performed using a web-based system via a pass word protected encrypted website interface.
The study procedure utilizes routine six-monthly clinic visits for study follow-up to increase efficiency and minimize the burden on participants.
The analysis will be based on intention-to-treat principles. An independent Data Safety and Monitoring Board (DSMB) will established to monitor the study for safety and efficacy.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Aspirin
Aspirin tablet 100mg daily
Aspirin 100 mg Oral Tablet
Aspirin 100 mg tablet daily
Matching Placebo
Placebo tablet 1 pill daily
Matching Placebo
Matching Placebo 1 pill daily
Interventions
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Aspirin 100 mg Oral Tablet
Aspirin 100 mg tablet daily
Matching Placebo
Matching Placebo 1 pill daily
Eligibility Criteria
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Inclusion Criteria
* Commenced on dialysis with the expectation of ongoing maintenance dialysis requirement.
* Willing and able to provide informed consent for this study.
Exclusion Criteria
* Contraindication to aspirin, in the view of the treating physician.
* Dialysis requirement due to acute kidney injure with expectation of kidney function recovery.
* History of haemorrhagic stroke or intracranial bleed within 12 months of screening.
* Coagulopathy from any cause.
* Unable to provide informed consent.
18 Years
ALL
No
Sponsors
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The George Institute
OTHER
Guangdong Provincial People's Hospital
OTHER
Responsible Party
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Principal Investigators
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Xueqing Yu
Role: STUDY_CHAIR
Guangdong Provincial People's Hospital
Vlado Perkovic
Role: STUDY_CHAIR
The University of New South Wales Sydney
Muh Geot Wong
Role: STUDY_DIRECTOR
The George Institute
Wei Chen
Role: STUDY_DIRECTOR
First Affiliated Hospital, Sun Yat-Sen University
Li Fan
Role: STUDY_DIRECTOR
Guangdong Provincial People's Hospital
Zhiming Ye
Role: STUDY_DIRECTOR
Guangdong Provincial People's Hospital
Locations
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The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China
Shanghang County Hospital
Longyan, Fujian, China
The First Hospital of Lanzhou University
Lanzhou, Gansu, China
Dongguan Donghua Hospital
Dongguan, Guangdong, China
Dongguan Hospital of Integrative Traditional Chinese and Western Medicine
Dongguan, Guangdong, China
Dongguan Houjie Hospital
Dongguan, Guangdong, China
Dongguan Eighth People's Hospital
Dongguan, Guangdong, China
Dongguan Marina Bay Center Hospital
Dongguan, Guangdong, China
Dongguan People's Hospital
Dongguan, Guangdong, China
Dongguan Songshan Lake Center Hospital
Dongguan, Guangdong, China
Lufeng People's Hospital
Donghai, Guangdong, China
Foshan Gaoming District People's Hospital
Foshan, Guangdong, China
The Second People Hospital of Foshan Nanhai
Foshan, Guangdong, China
Foshan Nanhai District People's Hospital
Foshan, Guangdong, China
Foshan No.1 people's hospital
Foshan, Guangdong, China
Foshan Sanshui People's Hospital
Foshan, Guangdong, China
Foshan Second People's Hospital
Foshan, Guangdong, China
Guangdong Provincial Hospital of Integrative Medicine
Foshan, Guangdong, China
The Third Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangdong Medical University
Guangzhou, Guangdong, China
Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, China
Guangzhou Redcross Hospital
Guangzhou, Guangdong, China
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, China
Guangdong Provincial Hospital of Traditional Chinese Medicine Fangcun Branch (Guangzhou Charity Hospital)
Guangzhou, Guangdong, China
The First Affiliated Hospital of Jinan University
Guangzhou, Guangdong, China
The Fifth Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, China
Guangdong Agricultural Reclamation Central Hospital
Guangzhou, Guangdong, China
Guangdong Cliffod Hospital
Guangzhou, Guangdong, China
Guangdong Provincial Peoples Hospital
Guangzhou, Guangdong, China
Guangzhou First People's Hospital
Guangzhou, Guangdong, China
Hua Du District People's Hospital of Guangzhou
Guangzhou, Guangdong, China
Panyu District people's hospital of Guangzhou
Guangzhou, Guangdong, China
The Fifth Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
The Sixth Affiliated Hospital of Sun yat-sen University
Guangzhou, Guangdong, China
The Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Sun Yat-sen University
Guanzhou, Guangdong, China
Heyuan People's Hospital
Heyuan, Guangdong, China
Huizhou First People Hospital
Huizhou, Guangdong, China
Huizhou Central People's Hospital
Huizhou, Guangdong, China
The People's Hospital of Jiangmen
Jiangmen, Guangdong, China
Jiangmen Center hospital
Jiangmen, Guangdong, China
Jieyang People's Hospital
Jieyang, Guangdong, China
Kaiping Center Hospital
Kaiping, Guangdong, China
Lianjiang People's Hospital
Lianjiang, Guangdong, China
Lianping County People's Hospital
Lianping, Guangdong, China
The Fourth Affiliated Hospital of Guangzhou Medical University
Licheng, Guangdong, China
Maoming Hospital of Traditional Chinese Medicine
Maoming, Guangdong, China
Maoming People's Hospital
Maoming, Guangdong, China
Meizhou People's Hospital
Meizhou, Guangdong, China
The Third Affiliated Hospital of Sun Yat-sen University Yuedong Hospital
Meizhou, Guangdong, China
Puning People's Hospital
Puning, Guangdong, China
Qingyuan People's Hospital
Qingyuan, Guangdong, China
Fogang People Hospital
Qingyuan, Guangdong, China
Qingyuan Hospital of Traditional Chinese Medicine
Qingyuan, Guangdong, China
The Second Affiliated Hospital of Shantou University Medical College
Shantou, Guangdong, China
The first Affiliated Hospital of Shantou Medical University
Shantou, Guangdong, China
Shantou Chaonan Minsheng Hospital
Shantou, Guangdong, China
Shanwei People's Hospital
Shanwei, Guangdong, China
Shenshan Medical Center, Memorial Hospital of Sun Yat-sen University
Shanwei, Guangdong, China
Wengyuan People Hospital
Shaoguan, Guangdong, China
Shaoguan First People's Hospital
Shaoguan, Guangdong, China
The First People's Hospital of Shaoguan
Shaoguan, Guangdong, China
Yuebei People's Hospital
Shaoguan, Guangdong, China
The Seventh Affiliated Hospital of Sun Yat-sen
Shenzhen, Guangdong, China
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China
Shenzhen Baoan People's Hospital
Shenzhen, Guangdong, China
Shenzhen Hospital of Southern Medical University
Shenzhen, Guangdong, China
Shenzhen Longhua District People's Hospital
Shenzhen, Guangdong, China
Shenzhen No.2 people's hospital
Shenzhen, Guangdong, China
The Eighth Affiliated Hospital of Sun Yat-sen University (Futian, Shenzhen)
Shenzhen, Guangdong, China
ShunDe Hospital Guangzhou University of Chinese Medicine
Shunde, Guangdong, China
The Eighth Affiliated Hospital of Southern Medical University, The First People's Hospital of Shunde
Shunde, Guangdong, China
Nanxiong People Hospital
Xiongzhou, Guangdong, China
People's Hospital of Yangdong District Yangjiang City
Yangjiang, Guangdong, China
Yangjiang Hospital of Traditional Chinese Medicine
Yangjiang, Guangdong, China
Yangjiang People's Hospital
Yangjiang, Guangdong, China
People Hospital of Yingde City Guangdong Province
Yingcheng, Guangdong, China
Yunfu People's Hospital
Yunfu, Guangdong, China
The Affiliated Hospital of Guangdong Medical University
Zhanjiang, Guangdong, China
Central People's Hospital of Zhanjiang
Zhanjiang, Guangdong, China
The Third Affiliated Hospital of Sun Yat-sen University Zhaoqing Hospital
Zhaoqing, Guangdong, China
Zhaoqing first people's hospital
Zhaoqing, Guangdong, China
Zhongshan City People's Hospital
Zhongshan, Guangdong, China
Zhongshan Traditional Chinese Hospital
Zhongshan, Guangdong, China
Zhongshan Xiaolan People's Hospital
Zhongshan, Guangdong, China
Jinwan Center Hospital of Zhuhai
Zhuhai, Guangdong, China
The fifth affiliated hospital of sun yat-sen university
Zhuhai, Guangdong, China
Zhuhai People's Hospital
Zhuhai, Guangdong, China
Shantou Central Hospital
Shantou, Guanggong, China
The Affiliated Hospital of Youjiang Ethnic Medicine College
Baise City, Guangxi, China
The first affiliated hospital of Guangxi Medical University
Nanning, Guangxi, China
Anshun Xixiu District People's Hispital
Anshun, Guizhou, China
China Guihang 302 Hospital
Anshun, Guizhou, China
Anshun People Hospital
Anshun, Guizhou, China
Guizhou Province Peple's Hospital
Guiyang, Guizhou, China
The First Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China
Hainan Provincial People's Hospital
Haikou, Hainan, China
Xinyang Central Hospital
Xinyang, Henan, China
Huangshi Central Hospital
Huangshi, Hubei, China
Jingmen Central Hospital
Jingmen, Hubei, China
Jingzhou Central Hospital
Jingzhou, Hubei, China
Wuhan Puren Hospital
Wuhan, Hubei, China
The First People's Hospital of Jiangxia District, Wuhan City
Wuhan, Hubei, China
The Central Hospital of Wuhan
Wuhan, Hubei, China
The Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China
Tongji Hospital, Tongji Medical College of Huazhong Science and Technology University
Wuhan, Hubei, China
Wuhan No.1 People's Hospital
Wuhan, Hubei, China
Yichang central people's hospital
Wuhan, Hubei, China
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China
Xiangyang Central Hospital
Xiangyang, Hubei, China
Hunan Provincial People's Hospital
Changsha, Hunan, China
The third Xiangya Hospital of Central South University
Changsha, Hunan, China
Xiangya Hospital Central South University
Changsha, Hunan, China
The Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China
Nantong Haimen People's Hospital
Nantong, Jiangsu, China
Xuzhou Mining Group General Hospital
Xuzhou, Jiangsu, China
Subei People's Hospital
Yangzhou, Jiangsu, China
Ganzhou Municiple Hospital
Ganzhou, Jiangxi, China
Ganzhou People's Hospital
Ganzhou, Jiangxi, China
Jiujiang No.1people's Hospital
Jiujiang, Jiangxi, China
Jiangxi Province Peple's Hospital
Nanchang, Jiangxi, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital)
Xi’an, Shanxi, China
The First Affiliated Hospital of Air Force Military Medical University
Xi’an, Shanxi, China
Sichuan Province People's Hospital
Chengdu, Sichuan, China
Jiashi County People's Hospital
Kashgar, Xinjiang, China
Shache County People's Hospital
Kashgar, Xinjiang, China
The First People's Hospital of Kashi Prefecture
Kashgar, Xinjiang, China
The Second People's Hospital of Kashi Prefecture
Kashgar, Xinjiang, China
The First Affiliated Hospital of Shihezi University Medical College
Shihezi, Xinjiang, China
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
The People's hospital of Xinjiang Uygur Autonomous Region
Ürümqi, Xinjiang, China
Fengqing People's Hospital of Yunnan Province
Lincang, Yunnan, China
The First Affiliated Hospital, Zhejiang University
Hangzhou, Zhejiang, China
Lishui City Center Hospital
Lishui, Zhejiang, China
Zhoushan Hospital
Zhoushan, Zhejiang, China
Countries
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Central Contacts
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Facility Contacts
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Jianxin Wan
Role: primary
Jianzhong Su
Role: primary
Tianxi Liu
Role: primary
Xiaoyan Su
Role: primary
Huan Lu
Role: primary
Changchang Xiao
Role: primary
Zhixiong Lin
Role: primary
Houqin Xiao
Role: primary
Guohui Liu
Role: primary
Tao Feng
Role: primary
Xia Jiang
Role: primary
Fuzhang Luo
Role: primary
Yaozhong Kong
Role: primary
Sinian Chen
Role: primary
Bo Zhang
Role: primary
Min Zhang
Role: primary
Ying Tang
Role: primary
Huafeng Liu
Role: primary
Qiongqiong Yang
Role: primary
Yan Liu
Role: primary
Haibo Long
Role: primary
Youguang Liu
Role: backup
Lixin Wang
Role: primary
Panna Liu
Role: primary
Huixin Bi
Role: primary
Jiping Wang
Role: primary
Yanchun Wang
Role: primary
Xueqing Yu
Role: primary
Shuguang Qin
Role: primary
Yunfang Zhang
Role: primary
Minyan Xie
Role: primary
Jie Xiao
Role: primary
Gangyi Chen
Role: primary
Zongpei Jiang
Role: primary
Hui Peng
Role: primary
Jianteng Xie
Role: primary
Yanbo Teng
Role: primary
Yongjun Shi
Role: primary
Danhong Yu
Role: primary
Qingdong Xu
Role: primary
Qinhua Liu
Role: primary
Wei Chen
Role: primary
Weipeng Huang
Role: primary
Jumei Xia
Role: primary
Chaohui Wen
Role: primary
Yeming Lu
Role: primary
Xinghua Zhu
Role: primary
Zhibo Liao
Role: primary
Muqun Shen
Role: primary
Zhiqiang Xue
Role: primary
Youhe Li
Role: primary
Huaiyuan Mao
Role: primary
Yanqiang Peng
Role: primary
Yubin Xia
Role: primary
Jinxiong Xu
Role: primary
Hongbo Ye
Role: primary
Yaoli Huang
Role: primary
Bin Zhou
Role: primary
Bing Zhou
Role: primary
Min He
Role: primary
Zhihua Zheng
Role: primary
Zibo Xiong
Role: primary
Jihong Chen
Role: primary
Lifen Wang
Role: primary
Mingliang Hu
Role: primary
Tiecheng Yang
Role: primary
Mou Liang
Role: primary
Xianrui Dou
Role: primary
Lingjun Zeng
Role: primary
Yang Chen
Role: primary
Yingchao Zhong
Role: primary
Yong Su
Role: primary
Chifeng Wang
Role: primary
Xinyuan Liao
Role: primary
Huafeng Liu
Role: primary
Lei Zeng
Role: primary
Hua Tang
Role: primary
Jinquan Wu
Role: primary
Qing Ye
Role: primary
Xianggeng Chi
Role: primary
Juan Pang
Role: primary
Cheng Wang
Role: primary
Rui Zhang
Role: primary
Liaohua Qu
Role: primary
Xucheng Li
Role: backup
Jie Wang
Role: primary
Zhenhua Yang
Role: primary
Li Zhao
Role: primary
Yansong Xu
Role: primary
Xianfeng Cheng
Role: primary
Yongjun Zhu
Role: primary
Jiali Wei
Role: primary
Bo Zhang
Role: primary
Jian Chen
Role: primary
Yuan Tian
Role: primary
Xiaotie Tang
Role: primary
Caixia Song
Role: primary
Wenli Chen
Role: primary
Chun Zhang
Role: primary
Gang Xu
Role: primary
Yanmin Zhang
Role: primary
Hai Yuan
Role: primary
Yumei Liang
Role: primary
Hao Zhang
Role: primary
Xiangcheng Xiao
Role: primary
Weidong Yuan
Role: primary
Xinglei Zhou
Role: primary
Guangyu Bi
Role: primary
Zhuo Li
Role: primary
Hongxia Peng
Role: primary
Xiaoran Feng
Role: primary
Aimin Zhong
Role: primary
Qinkai Chen
Role: primary
Menghua Chen
Role: primary
Rongguo Fu
Role: primary
Li Wang
Role: primary
Minfeng Liang
Role: primary
Yuxia Zhong
Role: primary
Shanshan Zhou
Role: primary
Jie Guo
Role: primary
Xiaoping Yang
Role: primary
Jinfeng Guo
Role: primary
Jianghua Chen
Role: primary
Lie Jin
Role: primary
Other Identifiers
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GDPH-CH-2774
Identifier Type: -
Identifier Source: org_study_id
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