Observational Research on Infectious Disease Outbreaks and Difficult Cases of Unidentified Etiology in Indonesia

NCT ID: NCT04339179

Last Updated: 2024-10-15

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

185 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-11-18

Study Completion Date

2022-07-08

Brief Summary

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This observational study will investigate suspected infectious diseases of unknown etiology prospectively during outbreaks and at healthcare facilities, and retrospectively through historical samples where no etiology was ever determined. The study is designed to rapidly, flexibly, and consistently respond to any potential scenario in Indonesia, and the data collected will provide needed insight into the landscape of infectious diseases in the country. By better understanding the infectious causes of outbreaks and difficult hospitalized cases, the Indonesian Ministry of Health will be able to more accurately and efficiently control infectious diseases and craft healthcare policies.

Detailed Description

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This is a study to identify the causative agents and describe the clinical characteristics of infectious disease outbreaks and difficult cases of unidentified etiology in Indonesia. It is a retrospective and prospective observational study with an exploratory design. There will be no intervention to the participants that is intended to affect their SoC or clinical outcome.

Retrospective study activities will be ongoing throughout the duration of the study. The INA-RESPOND Reference Lab will perform research tests on various specimens collected as part of historical outbreaks and previous difficult cases where an etiology was never identified.

Prospective study activities will be initiated upon official request from health authorities and health facilities/institutions. Requests are expected to be filtered through and evaluated by the 19 active INA-RESPOND Network sites before inclusion in the study. Samples collected during outbreaks and from difficult cases of unknown etiology will be analyzed at the INA-RESPOND Reference Lab at their own pace. Results from any research tests will be shared with the requesting authorities as research-use-only and are not intended to alter standard of care.

Conditions

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Infectious Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Adult or child of any age hospitalized with a current episode of illness with a presumed infectious disease of unidentified etiology
2. Negative for Dengue virus infection by an antigen-based and antibody-based diagnostic test (i.e. NS1 antigen test and Dengue-specific IgM test)
3. Negative for Salmonella Typhi infection by Standard of Care testing (i.e. blood culture, Widal test, or Tubex rapid test)
4. Able to provide a documented informed consent
5. Agrees to the collection and storage of specimens for laboratory testing and/or future research (participants may decline storage of specimens for future research)
6. For Ongoing patients in outbreak situations: Referral from the MoH as part of a suspected or identified outbreak of infectious disease

Exclusion Criteria

* Investigators' discretion for patient safety and well being
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ina-Respond

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dr. Muhammad Karyana, MPH

Role: PRINCIPAL_INVESTIGATOR

National Institute of Health Research and Development, Ministry of Health Republic of Indonesia

Locations

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Site 520: University of Udayana/Sanglah Hospital

Denpasar, Bali, Indonesia

Site Status

Site 560: University of Diponegoro/ Dr. Kariadi Hospital

Semarang, Central of Java, Indonesia

Site Status

Site 530: University of Indonesia/ Dr. Cipto Mangunkusumo Hospital

Jakarta, DKI Jakarta, Indonesia

Site Status

Site 540: Penyakit Infeksi Sulianti Saroso Hospital

Jakarta, DKI Jakarta, Indonesia

Site Status

Site 590: Persahabatan Hospital

Jakarta, DKI Jakarta, Indonesia

Site Status

Site 660 RSUD Abdul Wahab Sjahranie

Samarinda, East Kalimantan, Indonesia

Site Status

Site 700 - RSUD Dr.TC Hillers

Maumere, East Nusa Tenggara, Indonesia

Site Status

Site 570: University of Airlangga/ Dr. Soetomo Hospital

Surabaya, East of Java, Indonesia

Site Status

Site 600 : Adam Malik Hospital

Medan, North Sumatra, Indonesia

Site Status

Site 650: Budi Kemuliaan Hospital

Batam, Riau Islands, Indonesia

Site Status

Site 630: M. Ansari Saleh Hospital

Banjarmasin, South Kalimantan, Indonesia

Site Status

Site 690 - RSUD Abepura

Jayapura, Special Region of Papua, Indonesia

Site Status

Site 510: University of Padjajaran/ Dr. Hasan Sadikin Hospital

Bandung, West Java, Indonesia

Site Status

Site 610 : RSU Kabupaten Tangerang

Tangerang, West Java, Indonesia

Site Status

Site 680 - RSUD dr Soedarso

Pontianak, West Kalimantan, Indonesia

Site Status

Site 670 - RSUD Dr. Zainoel Abidin

Banda Aceh, , Indonesia

Site Status

Site 640: St. Carolus Hospital

Jakarta, , Indonesia

Site Status

Site 550: University of Hassanudin/ Dr. Wahidin Sudirohusodo Hospital

Makassar, , Indonesia

Site Status

Site 580: University of Gadjah Mada/ Dr. Sardjito Hospital

Yogyakarta, , Indonesia

Site Status

Countries

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Indonesia

Provided Documents

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Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form

View Document

Other Identifiers

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U1111-1263-1317

Identifier Type: OTHER

Identifier Source: secondary_id

INA107

Identifier Type: -

Identifier Source: org_study_id

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