Outcome of Cataract Surgery With Uveitis

NCT ID: NCT04333069

Last Updated: 2020-04-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-04-10

Study Completion Date

2022-12-20

Brief Summary

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Aim of the study is to evaluate outcome of cataract surgery in different types of uveitis as regarding best corrected visual acuity (BCVA) and rate of post operative complications.

Detailed Description

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Cataract is the main cause of reversible blindness in patients with uveitis. Cataract occurs in up to 50% to 70% of patients with uveitis.

Preoperative complications, including anterior synechiae, posterior synechiae, and pupillary membrane formation, may increase surgical challenges. In addition, recurrent inflammation increases the incidence of postoperative complications and often affects the visual prognosis. In recent years, phacoemulsification with intra ocular lens (IOL)implantation has become the main surgical method for treating uveitis (complicated cataract), and the visual prognosis of patients who undergo this procedure is usually favorable.

Surgical treatment may be effective but is associated with higher rates of complication than in non uveitic eyes. Cystoid macular edema (CME) is the most common complication cataract surgery in the general population. Although, in most cases, the macular edema is self-limited, in rare cases it can lead to long-term visual deterioration that is difficult to treat.

Another common complication after cataract surgery is posterior capsule opacification (PCO) , leading to symptoms of glare or blurred vision, reduced visual acuity, or impaired posterior segment exam. Factors that are critical in the development of PCO include surgical technique, type of implanted intra ocular lens (IOL) either foldable hydrophilic acrylic, hydrophobic acrylic or silicone and postoperative control of uveitis

Conditions

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Cataract; Complicata

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Uncorrected and best corrected visual acuity

Measuring of uncorrected and best corrected visual acuity after phaco emulsification and irrigation aspiration cataract surgery

Group Type OTHER

cataract surgery

Intervention Type PROCEDURE

cataract surgery in form of phaco emulsification or irrigation aspiration

Interventions

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cataract surgery

cataract surgery in form of phaco emulsification or irrigation aspiration

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

\- Visually significant cataract ( means opacification of the crystalline lens adequate to interfere with vision)in patients with uveitis controlled for at least 1month.

Exclusion Criteria

* Irreversible pathology affecting outcome e.g. macular scar ,optic atrophy, and retinal detachment.
* Patients with active uveitis (means inflammation inside the eye).
* Patients less than 16 years old.
Minimum Eligible Age

16 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Mona Abdallah Abdal Razik Ahmed

Assistant lecturer at Ophthalmology departmentAssiut University Faculty of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ashraf Khalaf Al Husseini, professor

Role: STUDY_DIRECTOR

Assiut University

Wael Mohammed Ahmed Soliman, professor

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Central Contacts

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Mona Abdallah Abd AlRazik Ahmed, MD

Role: CONTACT

01014398129

Mohammed Gamal Saleh, lecturer

Role: CONTACT

01004530716

References

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Carpentier SJ, Jung JL, Patnaik JL, Pecen PE, Palestine AG. A Cross-Sectional Online Survey Identifies Subspecialty Differences in the Management of Pediatric Cataracts Associated with Uveitis. Ophthalmol Ther. 2020 Jun;9(2):293-303. doi: 10.1007/s40123-020-00245-x. Epub 2020 Mar 10.

Reference Type BACKGROUND
PMID: 32157612 (View on PubMed)

Chen JL, Bhat P, Lobo-Chan AM. Perioperative Management of Uveitic Cataracts. Adv Ophthalmol Optom. 2019 Aug;4:325-339. doi: 10.1016/j.yaoo.2019.04.014. Epub 2019 May 18.

Reference Type BACKGROUND
PMID: 31788579 (View on PubMed)

Yangzes S, Seth NG, Singh R, Gupta PC, Jinagal J, Pandav SS, Gupta V, Gupta A, Ram J. Long-term outcomes of cataract surgery in children with uveitis. Indian J Ophthalmol. 2019 Apr;67(4):490-495. doi: 10.4103/ijo.IJO_846_18.

Reference Type BACKGROUND
PMID: 30900580 (View on PubMed)

Jinagal J, Gupta G, Agarwal A, Aggarwal K, Akella M, Gupta V, Suri D, Gupta A, Singh S, Ram J. Safety and efficacy of dexamethasone implant along with phacoemulsification and intraocular lens implantation in children with juvenile idiopathic arthritis associated uveitis. Indian J Ophthalmol. 2019 Jan;67(1):69-74. doi: 10.4103/ijo.IJO_713_18.

Reference Type BACKGROUND
PMID: 30574896 (View on PubMed)

El Gharbawy SA, Darwish EA, Abu Eleinen KG, Osman MH. Efficacy of addition of nepafenac 0.1% to steroid eye drops in prevention of post-phaco macular edema in high-risk eyes. Eur J Ophthalmol. 2019 Jul;29(4):453-457. doi: 10.1177/1120672118799626. Epub 2018 Sep 11.

Reference Type BACKGROUND
PMID: 30203671 (View on PubMed)

Other Identifiers

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cat in uveitic patients

Identifier Type: -

Identifier Source: org_study_id

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