Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke
NCT ID: NCT04312269
Last Updated: 2025-08-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
70 participants
INTERVENTIONAL
2020-02-25
2026-01-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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All phase TMR
TMR during every stage of sleep
Targeted Memory Reactivation (TMR)
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
Slow-wave sleep (SWS) only TMR
TMR during slow-wave sleep only
Targeted Memory Reactivation (TMR)
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
Reduced frequency TMR
TMR during only subset of sessions
Targeted Memory Reactivation (TMR)
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
Sham TMR
Patients receive no TMR
Targeted Memory Reactivation (TMR)
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
Interventions
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Targeted Memory Reactivation (TMR)
Targeted memory reactivation (TMR) refers to the process of playing audio cues associated with specific learned material quietly during sleep in order to strengthen consolidation of specific memories during sleep.
Eligibility Criteria
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Inclusion Criteria
* Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening
* Severe to moderate motor impairment (FMA-UE of 7-40)
* At least some voluntary shoulder and elbow muscle activation
Exclusion Criteria
* Visual impairment (such as hemianopia) preventing full view of screen
* Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest)
* Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study
* Inability to understand or follow commands in English due to aphasia or other reason
* Diffuse or multifocal infarcts in both hemispheres
* Substantial arm pain preventing participation for 90 minutes a day
* Spasticity treatment (pharmacological or Botox) within last 3 months
* Ferromagnetic implants that are MRI incompatible
21 Years
100 Years
ALL
No
Sponsors
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Northwestern University
OTHER
Responsible Party
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Marc Slutzky
Associate Professor
Principal Investigators
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Marc W Slutzky, MD/PhD
Role: PRINCIPAL_INVESTIGATOR
Northwestern University
Locations
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Northwestern University
Chicago, Illinois, United States
Countries
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Central Contacts
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Other Identifiers
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SP0052149
Identifier Type: -
Identifier Source: org_study_id
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