Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers
NCT ID: NCT04310514
Last Updated: 2020-03-17
Study Results
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Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2020-03-09
2020-12-31
Brief Summary
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Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury.
30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol.
Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
DIAGNOSTIC
SINGLE
Study Groups
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Experimental: glucose - fructose - xylitol - saccharose
* glucose 35 g (500ml of 7% solution);
* fructose 35 g (500ml of 7% solution);
* xylitol 35 g (500ml of 7% solution);
* saccharose 35 g (500ml of 7% solution)
Fructose/glucose/xylitol/saccharose
1. Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
2. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
3. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
4. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
Experimental: fructose - glucose - saccharose - xylitol
* glucose 35 g (500ml of 7% solution);
* fructose 35 g (500ml of 7% solution);
* xylitol 35 g (500ml of 7% solution);
* saccharose 35 g (500ml of 7% solution)
Fructose/glucose/xylitol/saccharose
1. Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
2. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
3. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
4. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
Experimental: xylitol - saccharose - glucose - fructose
* glucose 35 g (500ml of 7% solution);
* fructose 35 g (500ml of 7% solution);
* xylitol 35 g (500ml of 7% solution);
* saccharose 35 g (500ml of 7% solution)
Fructose/glucose/xylitol/saccharose
1. Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
2. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
3. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
4. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
Experimental: saccharose - xylitol - fructose - glucose
* glucose 35 g (500ml of 7% solution);
* fructose 35 g (500ml of 7% solution);
* xylitol 35 g (500ml of 7% solution);
* saccharose 35 g (500ml of 7% solution)
Fructose/glucose/xylitol/saccharose
1. Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
2. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
3. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
4. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
Interventions
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Fructose/glucose/xylitol/saccharose
1. Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
2. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
3. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
4. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
Eligibility Criteria
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Inclusion Criteria
* well-trained soccer players
* informed consent
Exclusion Criteria
* sigificant changes in urinalysis
* creatinine level above normal values
18 Years
40 Years
ALL
Yes
Sponsors
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Medical University of Gdansk
OTHER
Responsible Party
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Wojciech Wolyniec
Principal Investigator
Principal Investigators
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Marcin Renke, prof
Role: STUDY_CHAIR
Medical University of Gdansk
Locations
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Medical University of Gdansk
Gdansk, , Poland
Countries
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Central Contacts
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References
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Wolyniec W, Szwarc A, Kasprowicz K, Zorena K, Jaskulak M, Renke M, Naczyk M, Ratkowski W. Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol. 2022 Oct 20;13:841056. doi: 10.3389/fphys.2022.841056. eCollection 2022.
Other Identifiers
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04-0532/09/776
Identifier Type: -
Identifier Source: org_study_id
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