Economic Evaluation of Vancomycin Therapeutic Drug Monitoring Methods
NCT ID: NCT04297176
Last Updated: 2022-08-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
65 participants
INTERVENTIONAL
2020-01-23
2021-07-02
Brief Summary
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Research questions: Which vancomycin therapeutic drug monitoring (TDM) approach is associated with superior economic outcomes?
-Objectives: In this proposed multicenter randomized controlled trial (RCT), we aim to compare the pharmacoeconomic outcomes of various vancomycin TDM approaches.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Traditional monitoring method
Patients are dosed using two timed vancomycin serum concentrations
Vancomycin-traditional dosing
The dose is calculated based on 2 vancomycin serum levels
One concentration method
Patients are dosed based on one timed vancomycin serum level
Vancomycin- Trough-only based dosing
The dose is calculated based on 1 vancomycin serum level (i.e. trough)
Interventions
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Vancomycin-traditional dosing
The dose is calculated based on 2 vancomycin serum levels
Vancomycin- Trough-only based dosing
The dose is calculated based on 1 vancomycin serum level (i.e. trough)
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* immunosuppression;
* vancomycin allergy;
* history of recurrent peritonitis
* administration of \< 4 doses of vancomycin
* pregnancy;
* hemoglobin \< 8 g/dL.
18 Years
ALL
No
Sponsors
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Qatar University
OTHER
Hamad Medical Corporation
INDUSTRY
Responsible Party
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Dr. Eman Zeyad Ibrahim Elmekaty
Clinical Pharmacist, Infectious Diseases Department, Communicable Diseases Center, Study Principle Investigator
Locations
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Hamad Medical Corporation
Doha, , Qatar
Countries
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Other Identifiers
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15418/15
Identifier Type: -
Identifier Source: org_study_id
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