External Evaluation of Vancomycin Population Pharmacokinetic Models

NCT ID: NCT05481788

Last Updated: 2022-08-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-16

Study Completion Date

2021-11-01

Brief Summary

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All patients treated with vancomycin hospitalized outside of ICU in Brest University Hospital from 1rst january 2019 to 1rst january 2021 will be screened for inclusion. Vancomycin dosage, age, weight and serum creatinin will be recorded.

Seven pharmacokinetic models' predictive performance will be evaluated on this database.

Using the best model, we will perform Monte-Carlo simulation to elaborate dosing nomograms and develop dosing recommandations of continuous infusion of vancomycin.

Detailed Description

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Monte Carlo simulations will be performed according to varying creatinin clearance values and weight, for both the loading dose and the maintenance dose.

Conditions

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Vancomycin Dosage

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* All patients hospitalized in Brest University Hospital,
* treated with vancomycin and receiving pharmacological monitoring
* between 1rst January 2019 and 1rst January 2021

Exclusion Criteria

* Missing data on vancomycin administration
* Refusal to be included in this study
* Hospitalisation in ICU
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Brest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Brest University Hospital

Brest, , France

Site Status

Countries

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France

Other Identifiers

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EOPMV - 29BRC21.0126

Identifier Type: -

Identifier Source: org_study_id

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