The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney

NCT ID: NCT04278495

Last Updated: 2020-02-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

96 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-09-01

Study Completion Date

2018-12-01

Brief Summary

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Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction. Nevertheless, these witnessed effects have not been yet translated into the clinical practice.

Detailed Description

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Conditions

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Losartan Adverse Reaction Uropathy Uropathy Obstructive

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Losartan

to receive the medication Cozaar (Losartan Potassium 25mg "Merck Sharp \& Dohme-UK"),

Group Type ACTIVE_COMPARATOR

Cozaar (Losartan Potassium 25mg)

Intervention Type DRUG

Cozaar (Losartan Potassium 25mg)

Placebo

to receive either placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo

Interventions

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Cozaar (Losartan Potassium 25mg)

Cozaar (Losartan Potassium 25mg)

Intervention Type DRUG

Placebo

Placebo

Intervention Type DRUG

Other Intervention Names

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Cozaar

Eligibility Criteria

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Inclusion Criteria

* anuric and oliguric patients
* calculuar ureteral obstruction

Exclusion Criteria

* anomalous kidney
* bilateral obstructed kidney
* history of recent use of angiotensin receptor blockers or angiotensin-converting enzyme inhibitors
* ASA score of \>3
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mansoura University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ahmed Shokier

Role: STUDY_CHAIR

Mansoura University

Locations

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Urology and nephrology center

Al Mansurah, Outside U.S./Canada, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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LOSARTAN.OBST.UROPATHY

Identifier Type: -

Identifier Source: org_study_id

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