Targeted Treatment for RET Fusion-Positive Advanced Non-Small Cell Lung Cancer (A LUNG-MAP Treatment Trial)

NCT ID: NCT04268550

Last Updated: 2025-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

124 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-04-08

Study Completion Date

2026-03-01

Brief Summary

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This phase II LUNG-MAP treatment trial studies how well selpercatinib works in treating patients with RET fusion-positive non-small cell lung cancer that is stage IV or has come back (recurrent). Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Detailed Description

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PRIMARY OBJECTIVE:

I. To evaluate the objective response rate (ORR) (confirmed complete or partial response) by blinded independent centralized review (BICR) associated with selpercatinib (LOXO-292) in patients with previously-treated stage IV or recurrent RET fusion-positive non-small cell lung cancer (NSCLC).

SECONDARY OBJECTIVES:

I. To evaluate the duration of BICR-assessed response among BICR responders. II. To evaluate the frequency and severity of toxicities. III. To evaluate the investigator-assessed objective response rate (confirmed complete or partial response).

IV. To evaluate duration of investigator-assessed response among patients with a response as determined by the local investigator.

V. To evaluate investigator-assessed progression-free survival (IA-PFS). VI. To evaluate BICR-assessed PFS. VII. To evaluate overall survival (OS).

VIII. Among patients with brain metastases at baseline:

VIIIa. To evaluate the central nervous system (CNS) response rate (confirmed complete response \[CR\]).

VIIIb. To evaluate the duration of intracranial response among patients with a CNS response.

TRANSLATIONAL MEDICINE OBJECTIVES:

I. To collect, process, and bank cell-free deoxyribonucleic acid (cfDNA) at baseline, progression, and end of treatment for future development of a proposal to evaluate comprehensive next-generation sequencing of circulating tumor deoxyribonucleic acid (ctDNA).

II. To establish a tissue/blood repository from patients with refractory non-small cell lung cancer (NSCLC).

OUTLINE:

Patients receive selpercatinib orally (PO) twice daily (BID) on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 6 months for 2 years and then at the end of 3 years from date of sub-study registration.

Conditions

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Recurrent Lung Non-Small Cell Carcinoma Stage IV Lung Cancer AJCC v8 Stage IVA Lung Cancer AJCC v8 Stage IVB Lung Cancer AJCC v8

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment (selpercatinib)

Patients receive selpercatinib orally PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Group Type EXPERIMENTAL

Selpercatinib

Intervention Type DRUG

Given PO

Interventions

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Selpercatinib

Given PO

Intervention Type DRUG

Other Intervention Names

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LOXO-292 RET Kinase Inhibitor LOXO-292

Eligibility Criteria

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Inclusion Criteria

* Patients must have been assigned to S1900B based on biomarker analysis of tissue and/or blood and determined to have RET fusion-positive NSCLC as defined here:

* Patients must have RET fusion-positive NSCLC as determined by the Foundation Medicine (FMI) tissue-assay, other tumor-based assays such as next-generation sequencing (NGS), polymerase chain reaction (PCR), or follicular in situ hybridization (FISH), or by cfDNA blood assay. Patients with RET fusions detected by immunohistochemistry (IHC) alone are not eligible. The testing must be done within a laboratory with Clinical Laboratory Improvement Act (CLIA), International Organization for Standardization (ISO/International Electrotechnical Commission (IEC), College of American Pathologists (CAP), or similar certification. Presence of RET fusions detected on tests performed outside of LUNGMAP must have been confirmed by the study biomarker review panel
* For patients whose prior therapy was for stage IV or recurrent disease, the patient must have received at least one line of a platinum-based chemotherapy regimen. For patients whose prior systemic therapy was for stage I-III disease only (i.e. patient has not received any treatment for stage IV or recurrent disease), disease progression on platinum-based chemotherapy must have occurred within one year from the last date that the patient received that therapy. Prior anti-PD-1/PD-L1 therapy, alone or in combination (e.g. nivolumab, pembrolizumab, or durvalumab) is allowed
* Patients must be negative for all additional validated oncogenic drivers that could cause resistance to LOXO-292 treatment. This includes EGFR sensitizing mutations, EGFR T790M, ALK gene fusion, ROS1 gene fusion, KRAS activating mutation, BRAF V600E mutation and MET exon 14 skipping mutation or high-level amplification and expression

* Note: EGFR, ALK, ROS, KRAS, and BRAF testing is performed as part of the LUNGMAP screening/pre-screening FoundationOne test. If prior data is not available, results from the FMI testing must be obtained prior to sub-study registration
* Patients must have measurable disease documented by computed tomography (CT) or magnetic resonance imaging (MRI). The CT from a combined positron emission tomography (PET)/CT may be used to document only non-measurable disease unless it is of diagnostic quality. Measurable disease must be assessed within 28 days prior to sub-study registration. Pleural effusions, ascites and laboratory parameters are not acceptable as the only evidence of disease. Non-measurable disease must be assessed within 42 days prior to sub-study registration. All disease must be assessed and documented on the Baseline Tumor Assessment Form. Patients whose only measurable disease is within a previous radiation therapy port must demonstrate clearly progressive disease (in the opinion of the treating investigator) prior to registration. CT and MRI scans must be submitted for central review via transfer of images and data (TRIAD)
* Patients must have a CT or MRI scan of the brain to evaluate for CNS disease within 42 days prior to sub-study registration
* Patients with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load on suppressive therapy within 28 days prior to registration
* Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. Patients with HCV infection who are currently on treatment must have an undetectable HCV viral load within 28 days prior to registration
* Patients with known human immunodeficiency virus (HIV) infection are eligible, provided they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 6 months prior to registration
* Patients must be able to swallow capsules
* Patients must have progressed (in the opinion of the treating physician) following the most recent line of therapy
* Patients must have recovered (=\< grade 1) from any side effects of prior therapy. Patients must not have received any radiation therapy within 14 days prior to sub-study registration
* Absolute neutrophil count (ANC) \>= 1,500/mcl (obtained within 28 days prior to sub-study registration)
* Platelet count \>= 100,000 mcl (obtained within 28 days prior to sub-study registration)
* Serum bilirubin =\< institutional upper limit of normal (IULN) (within 28 days prior to sub-study registration). For patients with liver metastases, bilirubin must be =\< 5 x IULN
* Either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =\< 2 x IULN (within 28 days prior to sub-study registration) (if both ALT and AST are done, both must be =\< 2 IULN). For patients with liver metastases, bilirubin and either ALT or AST must be =\< 5 x IULN (if both ALT and AST are done, both must be =\< 5 x IULN)
* Serum creatinine =\< the IULN or calculated creatinine clearance \>= 50 mL/min using the following Cockcroft-Gault formula (within 28 days prior to sub-study registration)
* Patients must have Zubrod performance status 0-1 documented within 28 days prior to sub-study registration
* Pre-study history and physical exam must be obtained within 28 days prior to sub-study registration
* No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years
* Patients must have electrolytes and blood urea nitrogen (BUN) performed within 14 days prior to sub-study registration
* Patients must agree to have blood specimens submitted for circulating tumor DNA (ctDNA)
* Patients must also be offered participation in banking and in the correlative studies for collection and future use of specimens
* Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
* As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
* Patients with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator)

Exclusion Criteria

* Patients must not have received any prior treatment with selective anti-RET inhibitors (anti-RET multikinase inhibitors are permitted)
* Patient must not have leptomeningeal disease, spinal cord compression or brain metastases unless: (1) metastases have been locally treated and have remained clinically controlled and asymptomatic for at least 14 days following treatment, and prior to registration, AND (2) patient has no residual neurological dysfunction and has been off corticosteroids for at least 24 hours prior to sub-study registration
* Patients must not have received any prior systemic therapy (systemic chemotherapy, immunotherapy or investigational drug) within 14 days prior to sub-study registration
* Patients must not be planning to receive any concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment while receiving treatment on this study. Concurrent use of hormones for non-cancer-related conditions (e.g., insulin for diabetes and hormone replacement therapy) is acceptable
* Patient must not have had a major surgery within 14 days prior to sub-study registration. Patient must have fully recovered from the effects of prior surgery in the opinion of the treating investigator
* Patients must not have any grade III/IV cardiac disease as defined by the New York Heart Association Criteria (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, and myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia
* Patients must not have a QT interval by Fridericia (QTcF) \> 470 msec based on the electrocardiogram (ECG) within 28 days prior to registration. It is suggested that a local cardiologist review the QTcF intervals
* Patients must not have any clinically significant uncontrolled systemic illness, including but not limited to uncontrolled infection, requiring intravenous antibiotics, unstable angina pectoris, myocardial infarction within the past 6 months, uncontrolled cardiac arrhythmias, uncontrolled hypertension, or uncontrolled diabetes mellitus

* Uncontrolled diabetes: Patients who have a diagnosis of diabetes must have an hemoglobin (Hb) A1C \< 7% within 28 days prior to registration. The same criterion will be used in patients with confirmed diagnosis of diabetes mellitus who have been on a stable dietary or therapeutic regimen for this condition in the last three months
* Uncontrolled blood pressure and hypertension: All blood pressure measurements within the 28 days prior to registration must be systolic blood pressure (SBP) =\< 180 and diastolic blood pressure (DBP) =\< 100. An exception can be made by a healthcare provider for a patient with a single blood pressure elevation who upon rechecking has a blood pressure within the parameters above
* Patients must not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of LOXO-292 (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, small bowel resection, or active peptic ulcer disease)
* Patients must not be planning to receive any strong inhibitors or inducers of CYP3A4 at least 14 days prior to sub-study registration and throughout protocol treatment
* Patients must not be planning to use proton pump inhibitors (PPIs) at least one week prior to sub-study registration and throughout protocol treatment
* Patients must not be pregnant or nursing. Women study patients of reproductive potential and fertile men study patients and their partners must abstain or use effective contraception (including barrier method) while receiving study treatment and for at least 3 months after the last dose of LOXO-292. Male study patients must agree not to donate sperm for 6 months after the last dose of LOXO-292. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

SWOG Cancer Research Network

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yasir Y Elamin

Role: PRINCIPAL_INVESTIGATOR

SWOG Cancer Research Network

Locations

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Fairbanks Memorial Hospital

Fairbanks, Alaska, United States

Site Status

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Site Status

Kaiser Permanente-Anaheim

Anaheim, California, United States

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Sutter Auburn Faith Hospital

Auburn, California, United States

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Kaiser Permanente-Baldwin Park

Baldwin Park, California, United States

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Kaiser Permanente-Bellflower

Bellflower, California, United States

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Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, United States

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Kaiser Permanente-Fontana

Fontana, California, United States

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Palo Alto Medical Foundation-Fremont

Fremont, California, United States

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Kaiser Permanente - Harbor City

Harbor City, California, United States

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Kaiser Permanente-Irvine

Irvine, California, United States

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Loma Linda University Medical Center

Loma Linda, California, United States

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Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, United States

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Kaiser Permanente-Cadillac

Los Angeles, California, United States

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Palo Alto Medical Foundation-Camino Division

Mountain View, California, United States

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Kaiser Permanente-Ontario

Ontario, California, United States

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Palo Alto Medical Foundation Health Care

Palo Alto, California, United States

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Stanford Cancer Institute Palo Alto

Palo Alto, California, United States

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Kaiser Permanente - Panorama City

Panorama City, California, United States

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Kaiser Permanente-Riverside

Riverside, California, United States

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Sutter Roseville Medical Center

Roseville, California, United States

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Sutter Medical Center Sacramento

Sacramento, California, United States

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University of California Davis Comprehensive Cancer Center

Sacramento, California, United States

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Kaiser Permanente-San Diego Zion

San Diego, California, United States

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California Pacific Medical Center-Pacific Campus

San Francisco, California, United States

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Kaiser Permanente-San Marcos

San Marcos, California, United States

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Palo Alto Medical Foundation-Santa Cruz

Santa Cruz, California, United States

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Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, United States

Site Status

Sutter Solano Medical Center/Cancer Center

Vallejo, California, United States

Site Status

Presbyterian Intercommunity Hospital

Whittier, California, United States

Site Status

Kaiser Permanente-Woodland Hills

Woodland Hills, California, United States

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University of Colorado Hospital

Aurora, Colorado, United States

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Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, United States

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UCHealth Memorial Hospital Central

Colorado Springs, Colorado, United States

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Memorial Hospital North

Colorado Springs, Colorado, United States

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Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, United States

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Poudre Valley Hospital

Fort Collins, Colorado, United States

Site Status

Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, United States

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North Colorado Medical Center

Greeley, Colorado, United States

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UCHealth Greeley Hospital

Greeley, Colorado, United States

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UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, United States

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Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, United States

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Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, United States

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UCHealth Lone Tree Health Center

Lone Tree, Colorado, United States

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Medical Center of the Rockies

Loveland, Colorado, United States

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McKee Medical Center

Loveland, Colorado, United States

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Hartford Hospital

Hartford, Connecticut, United States

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Veterans Affairs Connecticut Healthcare System-West Haven Campus

West Haven, Connecticut, United States

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Bayhealth Hospital Kent Campus

Dover, Delaware, United States

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Bayhealth Hospital Sussex Campus

Milford, Delaware, United States

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Mount Sinai Comprehensive Cancer Center at Aventura

Aventura, Florida, United States

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Mount Sinai Medical Center

Miami Beach, Florida, United States

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Moffitt Cancer Center

Tampa, Florida, United States

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Northside Hospital

Atlanta, Georgia, United States

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Northeast Georgia Medical Center Braselton

Braselton, Georgia, United States

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Atlanta VA Medical Center

Decatur, Georgia, United States

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Northside Hospital - Duluth

Duluth, Georgia, United States

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Northeast Georgia Medical Center-Gainesville

Gainesville, Georgia, United States

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Northside Hospital - Gwinnett

Lawrenceville, Georgia, United States

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Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, United States

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Suburban Hematology Oncology Associates - Snellville

Snellville, Georgia, United States

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Hawaii Cancer Care Inc-POB II

Honolulu, Hawaii, United States

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Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, United States

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Queen's Medical Center

Honolulu, Hawaii, United States

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Straub Clinic and Hospital

Honolulu, Hawaii, United States

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Queen's Cancer Center - Kuakini

Honolulu, Hawaii, United States

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Hawaii Cancer Care - Savio

‘Aiea, Hawaii, United States

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Pali Momi Medical Center

‘Aiea, Hawaii, United States

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Saint Luke's Mountain States Tumor Institute

Boise, Idaho, United States

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Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, United States

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Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, United States

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Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, United States

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Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, United States

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Illinois CancerCare-Bloomington

Bloomington, Illinois, United States

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Illinois CancerCare-Canton

Canton, Illinois, United States

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Illinois CancerCare-Carthage

Carthage, Illinois, United States

Site Status

Northwestern University

Chicago, Illinois, United States

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Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, United States

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Illinois CancerCare-Dixon

Dixon, Illinois, United States

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Crossroads Cancer Center

Effingham, Illinois, United States

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Illinois CancerCare-Eureka

Eureka, Illinois, United States

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NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, United States

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Illinois CancerCare-Galesburg

Galesburg, Illinois, United States

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NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, United States

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NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, United States

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Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, United States

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Illinois CancerCare-Macomb

Macomb, Illinois, United States

Site Status

Loyola University Medical Center

Maywood, Illinois, United States

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Cancer Care Center of O'Fallon

O'Fallon, Illinois, United States

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Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, United States

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Illinois CancerCare-Pekin

Pekin, Illinois, United States

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Illinois CancerCare-Peoria

Peoria, Illinois, United States

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Illinois CancerCare-Peru

Peru, Illinois, United States

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Illinois CancerCare-Princeton

Princeton, Illinois, United States

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Genesis Cancer Center - Silvis

Silvis, Illinois, United States

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Parkview Regional Medical Center

Fort Wayne, Indiana, United States

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Goshen Center for Cancer Care

Goshen, Indiana, United States

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Franciscan Health Indianapolis

Indianapolis, Indiana, United States

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Franciscan Health Mooresville

Mooresville, Indiana, United States

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Memorial Hospital of South Bend

South Bend, Indiana, United States

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Mary Greeley Medical Center

Ames, Iowa, United States

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McFarland Clinic PC - Ames

Ames, Iowa, United States

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McFarland Clinic PC-Boone

Boone, Iowa, United States

Site Status

Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, United States

Site Status

Mercy Cancer Center-West Lakes

Clive, Iowa, United States

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Greater Regional Medical Center

Creston, Iowa, United States

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Genesis Medical Center - East Campus

Davenport, Iowa, United States

Site Status

Genesis Cancer Care Institute

Davenport, Iowa, United States

Site Status

Iowa Cancer Specialists

Davenport, Iowa, United States

Site Status

Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, United States

Site Status

Mercy Medical Center - Des Moines

Des Moines, Iowa, United States

Site Status

McFarland Clinic PC-Trinity Cancer Center

Fort Dodge, Iowa, United States

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McFarland Clinic PC-Jefferson

Jefferson, Iowa, United States

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McFarland Clinic PC-Marshalltown

Marshalltown, Iowa, United States

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Mercy Medical Center-West Lakes

West Des Moines, Iowa, United States

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HaysMed University of Kansas Health System

Hays, Kansas, United States

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University of Kansas Cancer Center

Kansas City, Kansas, United States

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Olathe Health Cancer Center

Olathe, Kansas, United States

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University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, United States

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Salina Regional Health Center

Salina, Kansas, United States

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University of Kansas Health System Saint Francis Campus

Topeka, Kansas, United States

Site Status

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, United States

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University of Kentucky/Markey Cancer Center

Lexington, Kentucky, United States

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Medical Center of Baton Rouge

Baton Rouge, Louisiana, United States

Site Status

Ochsner High Grove

Baton Rouge, Louisiana, United States

Site Status

Ochsner Medical Center Kenner

Kenner, Louisiana, United States

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Ochsner Medical Center Jefferson

New Orleans, Louisiana, United States

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Harold Alfond Center for Cancer Care

Augusta, Maine, United States

Site Status

Waldo County General Hospital

Belfast, Maine, United States

Site Status

MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford

Biddeford, Maine, United States

Site Status

Penobscot Bay Medical Center

Rockport, Maine, United States

Site Status

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford

Sanford, Maine, United States

Site Status

Maine Medical Partners - South Portland

South Portland, Maine, United States

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Western Maryland Regional Medical Center

Cumberland, Maryland, United States

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UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, United States

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Saint Joseph Mercy Hospital

Ann Arbor, Michigan, United States

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Bronson Battle Creek

Battle Creek, Michigan, United States

Site Status

IHA Hematology Oncology Consultants-Brighton

Brighton, Michigan, United States

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Saint Joseph Mercy Brighton

Brighton, Michigan, United States

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IHA Hematology Oncology Consultants-Canton

Canton, Michigan, United States

Site Status

Saint Joseph Mercy Canton

Canton, Michigan, United States

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IHA Hematology Oncology Consultants-Chelsea

Chelsea, Michigan, United States

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Saint Joseph Mercy Chelsea

Chelsea, Michigan, United States

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Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, United States

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Henry Ford Hospital

Detroit, Michigan, United States

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Genesee Cancer and Blood Disease Treatment Center

Flint, Michigan, United States

Site Status

Genesee Hematology Oncology PC

Flint, Michigan, United States

Site Status

Genesys Hurley Cancer Institute

Flint, Michigan, United States

Site Status

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, United States

Site Status

Allegiance Health

Jackson, Michigan, United States

Site Status

West Michigan Cancer Center

Kalamazoo, Michigan, United States

Site Status

Sparrow Hospital

Lansing, Michigan, United States

Site Status

Hope Cancer Clinic

Livonia, Michigan, United States

Site Status

Saint Mary Mercy Hospital

Livonia, Michigan, United States

Site Status

Spectrum Health Reed City Hospital

Reed City, Michigan, United States

Site Status

Ascension Saint Mary's Hospital

Saginaw, Michigan, United States

Site Status

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, United States

Site Status

Marie Yeager Cancer Center

Saint Joseph, Michigan, United States

Site Status

Ascension Saint Joseph Hospital

Tawas City, Michigan, United States

Site Status

Munson Medical Center

Traverse City, Michigan, United States

Site Status

Metro Health Hospital

Wyoming, Michigan, United States

Site Status

IHA Hematology Oncology Consultants-Ann Arbor

Ypsilanti, Michigan, United States

Site Status

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, United States

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Essentia Health - Deer River Clinic

Deer River, Minnesota, United States

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Essentia Health Cancer Center

Duluth, Minnesota, United States

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Essentia Health Hibbing Clinic

Hibbing, Minnesota, United States

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Minneapolis VA Medical Center

Minneapolis, Minnesota, United States

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United Hospital

Saint Paul, Minnesota, United States

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Essentia Health Sandstone

Sandstone, Minnesota, United States

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Essentia Health Virginia Clinic

Virginia, Minnesota, United States

Site Status

University of Mississippi Medical Center

Jackson, Mississippi, United States

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Saint Francis Medical Center

Cape Girardeau, Missouri, United States

Site Status

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, United States

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Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, United States

Site Status

Parkland Health Center - Farmington

Farmington, Missouri, United States

Site Status

Truman Medical Centers

Kansas City, Missouri, United States

Site Status

University of Kansas Cancer Center - North

Kansas City, Missouri, United States

Site Status

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, United States

Site Status

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, United States

Site Status

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, United States

Site Status

Mercy Hospital Springfield

Springfield, Missouri, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Mercy Hospital South

St Louis, Missouri, United States

Site Status

Siteman Cancer Center-South County

St Louis, Missouri, United States

Site Status

Missouri Baptist Medical Center

St Louis, Missouri, United States

Site Status

Mercy Hospital Saint Louis

St Louis, Missouri, United States

Site Status

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, United States

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Missouri Baptist Outpatient Center-Sunset Hills

Sunset Hills, Missouri, United States

Site Status

Community Hospital of Anaconda

Anaconda, Montana, United States

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Bozeman Deaconess Hospital

Bozeman, Montana, United States

Site Status

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, United States

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OptumCare Cancer Care at Oakey

Las Vegas, Nevada, United States

Site Status

OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, United States

Site Status

Renown Regional Medical Center

Reno, Nevada, United States

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New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire, United States

Site Status

Solinsky Center for Cancer Care

Manchester, New Hampshire, United States

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Virtua Samson Cancer Center

Moorestown, New Jersey, United States

Site Status

Virtua Voorhees

Voorhees Township, New Jersey, United States

Site Status

University of New Mexico Cancer Center

Albuquerque, New Mexico, United States

Site Status

New Mexico Oncology Hematology Consultants

Albuquerque, New Mexico, United States

Site Status

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, United States

Site Status

Presbyterian Rust Medical Center/Jorgensen Cancer Center

Rio Rancho, New Mexico, United States

Site Status

Mary Imogene Bassett Hospital

Cooperstown, New York, United States

Site Status

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, United States

Site Status

University of Rochester

Rochester, New York, United States

Site Status

James J Peters VA Medical Center

The Bronx, New York, United States

Site Status

Randolph Hospital

Asheboro, North Carolina, United States

Site Status

Cone Health Cancer Center at Alamance Regional

Burlington, North Carolina, United States

Site Status

Rex Hematology Oncology Associates-Cary

Cary, North Carolina, United States

Site Status

Durham VA Medical Center

Durham, North Carolina, United States

Site Status

Rex Hematology Oncology Associates-Garner

Garner, North Carolina, United States

Site Status

Cone Health Cancer Center

Greensboro, North Carolina, United States

Site Status

Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, United States

Site Status

Rex Cancer Center

Raleigh, North Carolina, United States

Site Status

Rex Hematology Oncology Associates-Blue Ridge

Raleigh, North Carolina, United States

Site Status

Rex Cancer Center of Wakefield

Raleigh, North Carolina, United States

Site Status

Sanford Bismarck Medical Center

Bismarck, North Dakota, United States

Site Status

Sanford Broadway Medical Center

Fargo, North Dakota, United States

Site Status

Sanford Roger Maris Cancer Center

Fargo, North Dakota, United States

Site Status

UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, United States

Site Status

Strecker Cancer Center-Belpre

Belpre, Ohio, United States

Site Status

Geauga Hospital

Chardon, Ohio, United States

Site Status

Adena Regional Medical Center

Chillicothe, Ohio, United States

Site Status

Case Western Reserve University

Cleveland, Ohio, United States

Site Status

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, United States

Site Status

Grant Medical Center

Columbus, Ohio, United States

Site Status

The Mark H Zangmeister Center

Columbus, Ohio, United States

Site Status

Doctors Hospital

Columbus, Ohio, United States

Site Status

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, United States

Site Status

Marietta Memorial Hospital

Marietta, Ohio, United States

Site Status

OhioHealth Marion General Hospital

Marion, Ohio, United States

Site Status

UH Seidman Cancer Center at Landerbrook Health Center

Mayfield Heights, Ohio, United States

Site Status

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, United States

Site Status

UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, United States

Site Status

Licking Memorial Hospital

Newark, Ohio, United States

Site Status

University Hospitals Parma Medical Center

Parma, Ohio, United States

Site Status

Southern Ohio Medical Center

Portsmouth, Ohio, United States

Site Status

University Hospitals Portage Medical Center

Ravenna, Ohio, United States

Site Status

UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, United States

Site Status

ProMedica Flower Hospital

Sylvania, Ohio, United States

Site Status

University Hospitals Sharon Health Center

Wadsworth, Ohio, United States

Site Status

UH Seidman Cancer Center at Saint John Medical Center

Westlake, Ohio, United States

Site Status

UHHS-Westlake Medical Center

Westlake, Ohio, United States

Site Status

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, United States

Site Status

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Site Status

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, United States

Site Status

Kaiser Permanente Northwest

Portland, Oregon, United States

Site Status

Oregon Health and Science University

Portland, Oregon, United States

Site Status

Salem Hospital

Salem, Oregon, United States

Site Status

Fox Chase Cancer Center - East Norriton Hospital Outpatient Center

East Norriton, Pennsylvania, United States

Site Status

Ephrata Cancer Center

Ephrata, Pennsylvania, United States

Site Status

Adams Cancer Center

Gettysburg, Pennsylvania, United States

Site Status

Cherry Tree Cancer Center

Hanover, Pennsylvania, United States

Site Status

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, United States

Site Status

Sechler Family Cancer Center

Lebanon, Pennsylvania, United States

Site Status

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Site Status

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

Site Status

Temple University Hospital

Philadelphia, Pennsylvania, United States

Site Status

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, United States

Site Status

Pottstown Hospital

Pottstown, Pennsylvania, United States

Site Status

UPMC Susquehanna

Williamsport, Pennsylvania, United States

Site Status

WellSpan Health-York Cancer Center

York, Pennsylvania, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Easley

Easley, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Greer

Greer, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Spartanburg

Spartanburg, South Carolina, United States

Site Status

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, United States

Site Status

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, United States

Site Status

The Don and Sybil Harrington Cancer Center

Amarillo, Texas, United States

Site Status

Parkland Memorial Hospital

Dallas, Texas, United States

Site Status

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, United States

Site Status

Bon Secours Memorial Regional Medical Center

Mechanicsville, Virginia, United States

Site Status

Bon Secours Saint Francis Medical Center

Midlothian, Virginia, United States

Site Status

Bon Secours Saint Mary's Hospital

Richmond, Virginia, United States

Site Status

Jefferson Healthcare

Port Townsend, Washington, United States

Site Status

Edwards Comprehensive Cancer Center

Huntington, West Virginia, United States

Site Status

Langlade Hospital and Cancer Center

Antigo, Wisconsin, United States

Site Status

Duluth Clinic Ashland

Ashland, Wisconsin, United States

Site Status

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, United States

Site Status

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, United States

Site Status

Aurora Cancer Care-Grafton

Grafton, Wisconsin, United States

Site Status

Aurora BayCare Medical Center

Green Bay, Wisconsin, United States

Site Status

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, United States

Site Status

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, United States

Site Status

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, United States

Site Status

Aspirus Medford Hospital

Medford, Wisconsin, United States

Site Status

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, United States

Site Status

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, United States

Site Status

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, United States

Site Status

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Aurora Sinai Medical Center

Milwaukee, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, United States

Site Status

Aurora Cancer Care-Racine

Racine, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, United States

Site Status

Aurora Medical Center in Summit

Summit, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, United States

Site Status

Aspirus Regional Cancer Center

Wausau, Wisconsin, United States

Site Status

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, United States

Site Status

Aurora West Allis Medical Center

West Allis, Wisconsin, United States

Site Status

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, United States

Site Status

Marshfield Clinic - Weston Center

Weston, Wisconsin, United States

Site Status

Aspirus UW Cancer Center

Wisconsin Rapids, Wisconsin, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

NCI-2019-08097

Identifier Type: REGISTRY

Identifier Source: secondary_id

S1900B

Identifier Type: OTHER

Identifier Source: secondary_id

S1900B

Identifier Type: OTHER

Identifier Source: secondary_id

U10CA180888

Identifier Type: NIH

Identifier Source: secondary_id

View Link

S1900B

Identifier Type: -

Identifier Source: org_study_id

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