Molecular Analysis and Treatment Options of SCLC

NCT ID: NCT05945745

Last Updated: 2024-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-01

Study Completion Date

2028-12-31

Brief Summary

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Small cell lung cancer (SCLC) is an aggressive disease that is characterized by rapid growth and the early development of metastases. Patients typically respond to initial chemotherapy but quickly experience relapse, resulting in a poor long-term outcome. Therapeutic innovations that substantially improve survival have historically been limited, and reliable, predictive biomarkers are lacking.

Ongoing research has advanced the understanding of molecular categories and the immunologic microenvironment of SCLC, which in turn has helped improve disease classification and staging. Considering the role of molecular alterations has not yet fully to be defined in the treatment of SCLC, there is an urgent recognition that molecular alterations in the SCLC are important to predict response and survival for novel therapies and ongoing clinical trials. Advances in research have revealed critical information regarding biologic characteristics of the disease, which may lead to the identification of vulnerabilities and the development of new therapies. Further research focused on identifying biomarkers and evaluating innovative therapies will be paramount to improving treatment outcomes for patients with SCLC.

In summary, identification of (genetic) biomarkers in SCLC is increasingly essential to perform molecular diagnostics and individualized treatments. This project aims to create a registry of patients with SCCL to further the characterization of molecular alterations and develop (novel) treatments based on the detection.

Detailed Description

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Conditions

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Small-cell Lung Cancer Small Cell Lung Cancer, Combined Type Small Cell Lung Carcinoma Small Cell Lung Cancer Extensive Stage Small Cell Lung Cancer Limited Stage

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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Chemotherapy

different treatments based on the molecular analysis

Intervention Type DRUG

Other Intervention Names

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immunotherapy targeted therapy

Eligibility Criteria

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Inclusion Criteria

* Histologically proven diagnosis of SCLC
* 18 years of age or older
* Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria

* Histologically proven diagnosis of non-SCLC
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Chest Hospital

OTHER

Sponsor Role lead

Responsible Party

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Xiaomin Niu

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Shanghai Chest Hospital

Shanghai, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xiaomin Niu

Role: CONTACT

Facility Contacts

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Xiaomin Niu

Role: primary

021-22200000

Other Identifiers

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THORACIC004

Identifier Type: -

Identifier Source: org_study_id