Efficacy and Mechanisms of Mobile-Delivered Alcohol Attentional Bias Modification

NCT ID: NCT04263259

Last Updated: 2023-05-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-08

Study Completion Date

2021-08-14

Brief Summary

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This study evaluates the efficacy as well as psychological and neurobiological mechanisms of mobile-delivered alcohol attentional bias modification among heavy drinking adults.

Detailed Description

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By testing the efficacy and neurobiological mechanisms of behavior change (MOBC) following attentional bias modification among heavy drinking adults, the proposed study has the potential to unify dual process models and neurobiological models of addiction. The cognitive retraining will be delivered via mobile electronic devices to ensure the cost-effectiveness of these procedures, to allow a large amount of retraining to be delivered in an ecologically valid manner, and to facilitate broad dissemination of such procedures if found to be efficacious. Using an intensive longitudinal experimental design, subjects will be randomly assigned into one of 2 groups (attentional bias modification vs. attentional bias control). Ecological momentary assessment (EMA) data will be used to assess changes in cognitive and behavioral measures in situ, and functional magnetic resonance imaging (fMRI) scans before and after cognitive retraining will be used to examine neural changes in specific regions of interest (ROI).

Conditions

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Alcohol; Harmful Use

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants
Participants are not informed about the nature of the mobile-delivered intervention or their assignment to the intervention or control condition.

Study Groups

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Attentional Bias Modification

Participants complete attentional bias modification using a dot probe task on a mobile device up to 5 times per day for a 28-day period (80 trials per assessment).

Group Type EXPERIMENTAL

Attentional Bias Modification

Intervention Type BEHAVIORAL

Mobile-Delivered Cognitive Retraining Intervention

Attentional Bias Control

Participants complete attentional bias assessment-only using a dot probe task on a mobile device up to 5 times per day for a 28-day period (80 trials per assessment).

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Attentional Bias Modification

Mobile-Delivered Cognitive Retraining Intervention

Intervention Type BEHAVIORAL

Other Intervention Names

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Cognitive Retraining

Eligibility Criteria

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Inclusion Criteria

* Alcohol Use Disorders Identification Test greater than or equal to 8
* right-handed

Exclusion Criteria

* history of treatment for or diagnosis of alcohol use disorder/substance use disorder
* history of brain injury
* for females, currently pregnant
* any MRI safety contraindication
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

Sponsor Role collaborator

University of New Mexico

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Center on Alcoholism, Substance Abuse, & Addictions

Albuquerque, New Mexico, United States

Site Status

Mind Research Network

Albuquerque, New Mexico, United States

Site Status

Countries

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United States

Other Identifiers

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K01AA023233

Identifier Type: NIH

Identifier Source: secondary_id

View Link

13419

Identifier Type: -

Identifier Source: org_study_id

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