Return to Baseball After BFR Therapy for Shoulder Injury
NCT ID: NCT04248413
Last Updated: 2022-05-16
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
WITHDRAWN
Clinical Phase
NA
Study Classification
INTERVENTIONAL
Study Start Date
2022-05-31
Study Completion Date
2022-07-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The literature is limited on whether BFR therapy provides improved return to function after acute rotator cuff or biceps rehabilitation in non-operative cases, and whether there is a clear mechanism of action in musculotendinous repair after BFR therapy. The purpose of the study is to 1) evaluate patient reported outcomes and return to play in baseball athletes undergoing rehabilitation with blood flow restriction (BFR) therapy for shoulder injury and 2) evaluate changes in blood biomarkers to assess the mechanism of action of BFR therapy in injured athletes. Investigators will perform a randomized blinded placebo-controlled trial of 2 separate study populations: 1) baseball players with biceps or rotator cuff tendinopathy undergoing non-operative treatment with BFR therapy incorporated into routine physical rehabilitation and 2) baseball players with biceps or rotator cuff tendinopathy undergoing non-operative treatment with routine physical rehabilitation alone.
Primary outcomes will be functional outcomes and evaluation of return to sport. Functional outcomes will be evaluated using validated patient reported outcome surveys that are upper extremity-specific. Return to sport will be assessed by evaluating time to receiving clearance for returning to routine practices and reported level of physical performance and re-injury. Secondary outcomes will be measurement in muscle strength and blood biomarkers, as well as evaluation of 3D throwing motion. Strength will be measured using a biodex system at baseline prior to beginning physical rehabilitation, half-way through the rehabilitation protocol +/- BFR phase, and once cleared for return to play. Blood biomarkers GH, IGF-I, and IL-6 will be quantified at the same time points in order to investigate the mechanism of action of BFR on tissue repair. Patients will be followed longitudinally during this time for rates of reinjury.
Primary outcomes will be functional outcomes and evaluation of return to sport. Functional outcomes will be evaluated using validated patient reported outcome surveys that are upper extremity-specific. Return to sport will be assessed by evaluating time to receiving clearance for returning to routine practices and reported level of physical performance and re-injury. Secondary outcomes will be measurement in muscle strength and blood biomarkers, as well as evaluation of 3D throwing motion. Strength will be measured using a biodex system at baseline prior to beginning physical rehabilitation, half-way through the rehabilitation protocol +/- BFR phase, and once cleared for return to play. Blood biomarkers GH, IGF-I, and IL-6 will be quantified at the same time points in order to investigate the mechanism of action of BFR on tissue repair. Patients will be followed longitudinally during this time for rates of reinjury.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Blood Flow Restriction Therapy Following Acute Shoulder Injury Patients
NCT06223373
Shoulder Injury
TERMINATED
NA
BFR Therapy in Patients With Rotator Cuff Tears
NCT04384120
Blood Flow Restriction
TERMINATED
NA
Blood Flow Restriction in Post-surgery Rehabilitation of Latarjet Procedure
NCT06430567
Shoulder Dislocation
NOT_YET_RECRUITING
NA
Blood Flow Restriction Training Following Glenoid Labral Repair
NCT03675620
Glenoid Labrum Tear
WITHDRAWN
NA
Can Blood Flow Restriction Therapy Improve Strength and Cross-Sectional Area for Shoulder External Rotators Better Than Exercise Alone?
NCT04596020
Can Blood Flow Restriction Therapy Augments Strength Gains in the Rotator Cuff
Muscle Weakness
UNKNOWN
NA
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
This study will evaluate the efficacy of BFR therapy in physical rehabilitation for baseball athletes with non-operative biceps or rotator cuff tendinopathy. This will be directly measured by evaluation of upper extremity biomechanics measurements, strength testing, patient reported functional outcome scores, and identifying time required for clearance of return to sport. These outcomes in patients undergoing BFR therapy in addition to traditional rehabilitation will be compared to patients undergoing traditional rehabilitation only.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Musculoskeletal Injury
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
The purpose of the study is to 1) evaluate patient reported outcomes and return to play in baseball athletes undergoing rehabilitation with blood flow restriction (BFR) therapy for shoulder injury and 2) evaluate changes in blood biomarkers to assess the mechanism of action of BFR therapy in injured athletes.
Primary Study Purpose
TREATMENT
Blinding Strategy
DOUBLE
Investigators
Outcome Assessors
The PI who will be performing the analysis will be blinded to patients who underwent routine physical rehabilitation vs those who underwent routine rehabilitation plus blood flow restriction therapy.
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Standard rehabilitation protocol
Patients with non-operative rotator cuff and biceps tendinopathy assigned to this study arm will undergo the standardized physical rehabilitation protocol at our institution.
Group Type
OTHER
Standard physical rehabilitation
Intervention Type
OTHER
Patients diagnosed with non-operative rotator cuff or biceps tendinopathy will undergo physical rehabilitation under the supervision of the same physical therapists who will be performing the BFR therapy.
Standard rehabilitation plus Blood Flow Restriction Therapy
Patients with non-operative rotator cuff and biceps tendinopathy assigned to this study arm will undergo the standardized physical rehabilitation protocol at our institution in addition to the BFR therapy. Per recommendations of Owens Recovery Science, the organization responsible for certifying physical therapists in BFR therapy, the therapy will take place concurrently throughout the duration of the rehabilitation.
Group Type
EXPERIMENTAL
Blood Flow Restriction Therapy
Intervention Type
DEVICE
The blood flow restriction cuff, which is regulated by the FDA under 878.5910 and is registered under number 9681444, is manufactured by Delfi Medical. The cuff will be used as recommended by the manufacturer and Owens Recovery Science, the company who provides certificating of blood flow restriction training.
Standard physical rehabilitation
Intervention Type
OTHER
Patients diagnosed with non-operative rotator cuff or biceps tendinopathy will undergo physical rehabilitation under the supervision of the same physical therapists who will be performing the BFR therapy.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Blood Flow Restriction Therapy
The blood flow restriction cuff, which is regulated by the FDA under 878.5910 and is registered under number 9681444, is manufactured by Delfi Medical. The cuff will be used as recommended by the manufacturer and Owens Recovery Science, the company who provides certificating of blood flow restriction training.
Intervention Type
DEVICE
Standard physical rehabilitation
Patients diagnosed with non-operative rotator cuff or biceps tendinopathy will undergo physical rehabilitation under the supervision of the same physical therapists who will be performing the BFR therapy.
Intervention Type
OTHER
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* any injured baseball athletes ages 14 to 25 years with clinical and radiographic examination (MRI) consistent with a formal diagnosis of non-operative rotator cuff and/or biceps tendinopathy
* no prior upper extremity ipsilateral procedures or history of deep vein thrombosis
* no prior upper extremity ipsilateral procedures or history of deep vein thrombosis
Exclusion Criteria
* patients younger than 14 or older than 25 years of age
* non-native English speakers
* a history of revision surgery or prior ipsilateral upper extremity surgery, concomitant ligamentous, tendinous, or cartilage injury that would alter postoperative rehabilitation protocol
* inability to comply with the proposed follow-up clinic visits
* patients lacking decisional capacity.
* non-native English speakers
* a history of revision surgery or prior ipsilateral upper extremity surgery, concomitant ligamentous, tendinous, or cartilage injury that would alter postoperative rehabilitation protocol
* inability to comply with the proposed follow-up clinic visits
* patients lacking decisional capacity.
Minimum Eligible Age
14 Years
Maximum Eligible Age
25 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Wake Forest University Health Sciences
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Responsibility Role
SPONSOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Kristen F Nicholson, PhD
Role: PRINCIPAL_INVESTIGATOR
Wake Forest University Health Sciences
References
Explore related publications, articles, or registry entries linked to this study.
Abe T, Fujita S, Nakajima T, Sakamaki M, Ozaki H, Ogasawara R, Sugaya M, Kudo M, Kurano M, Yasuda T, Sato Y, Ohshima H, Mukai C, Ishii N. Effects of Low-Intensity Cycle Training with Restricted Leg Blood Flow on Thigh Muscle Volume and VO2MAX in Young Men. J Sports Sci Med. 2010 Sep 1;9(3):452-8. eCollection 2010.
Reference Type
BACKGROUND
Abe T, Yasuda T, Midorikawa T, et al. Skeletal muscle size and circulating IGF-1 are increased after two weeks of twice daily "KAATSU" resistance training. International Journal of KAATSU Training Research. 2005;1(1):6-12.
Reference Type
BACKGROUND
Blair JA, Eisenstein ED, Pierrie SN, Gordon W, Owens JG, Hsu JR. Lower Extremity Limb Salvage: Lessons Learned From 14 Years at War. J Orthop Trauma. 2016 Oct;30 Suppl 3:S11-S15. doi: 10.1097/BOT.0000000000000669.
Reference Type
BACKGROUND
Bowman EN, Elshaar R, Milligan H, Jue G, Mohr K, Brown P, Watanabe DM, Limpisvasti O. Proximal, Distal, and Contralateral Effects of Blood Flow Restriction Training on the Lower Extremities: A Randomized Controlled Trial. Sports Health. 2019 Mar/Apr;11(2):149-156. doi: 10.1177/1941738118821929. Epub 2019 Jan 14.
Reference Type
BACKGROUND
Burkhart SS, Morgan CD, Kibler WB. The disabled throwing shoulder: spectrum of pathology Part I: pathoanatomy and biomechanics. Arthroscopy. 2003 Apr;19(4):404-20. doi: 10.1053/jars.2003.50128.
Reference Type
BACKGROUND
Cancio J, Rhee P. Blood Flow Restriction Therapy after Non-Operative Management of Distal Radius Fracture: A Randomized Controlled Pilot Study. Journal of Hand Therapy. 2018;31(1).
Reference Type
BACKGROUND
Clarsen B, Myklebust G, Bahr R. Development and validation of a new method for the registration of overuse injuries in sports injury epidemiology: the Oslo Sports Trauma Research Centre (OSTRC) overuse injury questionnaire. Br J Sports Med. 2013 May;47(8):495-502. doi: 10.1136/bjsports-2012-091524. Epub 2012 Oct 4.
Reference Type
BACKGROUND
Conte S, Camp CL, Dines JS. Injury Trends in Major League Baseball Over 18 Seasons: 1998-2015. Am J Orthop (Belle Mead NJ). 2016 Mar-Apr;45(3):116-23.
Reference Type
BACKGROUND
Credeur DP, Hollis BC, Welsch MA. Effects of handgrip training with venous restriction on brachial artery vasodilation. Med Sci Sports Exerc. 2010 Jul;42(7):1296-302. doi: 10.1249/MSS.0b013e3181ca7b06.
Reference Type
BACKGROUND
Cvetanovich GL, Gowd AK, Liu JN, Nwachukwu BU, Cabarcas BC, Cole BJ, Forsythe B, Romeo AA, Verma NN. Establishing clinically significant outcome after arthroscopic rotator cuff repair. J Shoulder Elbow Surg. 2019 May;28(5):939-948. doi: 10.1016/j.jse.2018.10.013. Epub 2019 Jan 24.
Reference Type
BACKGROUND
Dahlgren LA, Mohammed HO, Nixon AJ. Temporal expression of growth factors and matrix molecules in healing tendon lesions. J Orthop Res. 2005 Jan;23(1):84-92. doi: 10.1016/j.orthres.2004.05.007.
Reference Type
BACKGROUND
Dankel SJ, Jessee MB, Abe T, Loenneke JP. The Effects of Blood Flow Restriction on Upper-Body Musculature Located Distal and Proximal to Applied Pressure. Sports Med. 2016 Jan;46(1):23-33. doi: 10.1007/s40279-015-0407-7.
Reference Type
BACKGROUND
Dines JS, Frank JB, Akerman M, Yocum LA. Glenohumeral internal rotation deficits in baseball players with ulnar collateral ligament insufficiency. Am J Sports Med. 2009 Mar;37(3):566-70. doi: 10.1177/0363546508326712. Epub 2008 Dec 4.
Reference Type
BACKGROUND
Erickson LN, Lucas KCH, Davis KA, Jacobs CA, Thompson KL, Hardy PA, Andersen AH, Fry CS, Noehren BW. Effect of Blood Flow Restriction Training on Quadriceps Muscle Strength, Morphology, Physiology, and Knee Biomechanics Before and After Anterior Cruciate Ligament Reconstruction: Protocol for a Randomized Clinical Trial. Phys Ther. 2019 Aug 1;99(8):1010-1019. doi: 10.1093/ptj/pzz062.
Reference Type
BACKGROUND
Escamilla RF, Barrentine SW, Fleisig GS, Zheng N, Takada Y, Kingsley D, Andrews JR. Pitching biomechanics as a pitcher approaches muscular fatigue during a simulated baseball game. Am J Sports Med. 2007 Jan;35(1):23-33. doi: 10.1177/0363546506293025. Epub 2006 Sep 14.
Reference Type
BACKGROUND
Fleisig GS, Barrentine SW, Zheng N, Escamilla RF, Andrews JR. Kinematic and kinetic comparison of baseball pitching among various levels of development. J Biomech. 1999 Dec;32(12):1371-5. doi: 10.1016/s0021-9290(99)00127-x.
Reference Type
BACKGROUND
Fujita S, Abe T, Drummond MJ, Cadenas JG, Dreyer HC, Sato Y, Volpi E, Rasmussen BB. Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. J Appl Physiol (1985). 2007 Sep;103(3):903-10. doi: 10.1152/japplphysiol.00195.2007. Epub 2007 Jun 14.
Reference Type
BACKGROUND
Gao S, Durstine JL, Koh HJ, Carver WE, Frizzell N, Carson JA. Acute myotube protein synthesis regulation by IL-6-related cytokines. Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C487-C500. doi: 10.1152/ajpcell.00112.2017. Epub 2017 Aug 2.
Reference Type
BACKGROUND
Garrison JC, Johnston C, Conway JE. BASEBALL PLAYERS WITH ULNAR COLLATERAL LIGAMENT TEARS DEMONSTRATE DECREASED ROTATOR CUFF STRENGTH COMPARED TO HEALTHY CONTROLS. Int J Sports Phys Ther. 2015 Aug;10(4):476-81.
Reference Type
BACKGROUND
Gilliam BD, Douglas L, Fleisig GS, Aune KT, Mason KA, Dugas JR, Cain EL Jr, Ostrander RV, Andrews JR. Return to Play and Outcomes in Baseball Players After Superior Labral Anterior-Posterior Repairs. Am J Sports Med. 2018 Jan;46(1):109-115. doi: 10.1177/0363546517728256. Epub 2017 Sep 25.
Reference Type
BACKGROUND
Goto K, Ishii N, Kizuka T, Takamatsu K. The impact of metabolic stress on hormonal responses and muscular adaptations. Med Sci Sports Exerc. 2005 Jun;37(6):955-63.
Reference Type
BACKGROUND
Hylden C, Burns T, Stinner D, Owens J. Blood flow restriction rehabilitation for extremity weakness: a case series. J Spec Oper Med. 2015 Spring;15(1):50-6.
Reference Type
BACKGROUND
Iversen E, Rostad V, Larmo A. Intermittent blood flow restriction does not reduce atrophy following anterior cruciate ligament reconstruction. J Sport Health Sci. 2016 Mar;5(1):115-118. doi: 10.1016/j.jshs.2014.12.005. Epub 2015 Apr 18.
Reference Type
BACKGROUND
Jo CH, Park JW, Shin JS. Changes of Muscle Atrophy According to the Immediate Postoperative Time Point in Magnetic Resonance Imaging After Arthroscopic Rotator Cuff Repair. Arthroscopy. 2016 Dec;32(12):2477-2487. doi: 10.1016/j.arthro.2016.04.032. Epub 2016 Jun 22.
Reference Type
BACKGROUND
Jobe FW, Kvitne RS, Giangarra CE. Shoulder pain in the overhand or throwing athlete. The relationship of anterior instability and rotator cuff impingement. Orthop Rev. 1989 Sep;18(9):963-75.
Reference Type
BACKGROUND
Julious SA. Sample size of 12 per group rule of thumb for a pilot study. Pharmaceutical Statistics. 2005;4(4):287-291.
Reference Type
BACKGROUND
Ladlow P, Coppack RJ, Dharm-Datta S, Conway D, Sellon E, Patterson SD, Bennett AN. Low-Load Resistance Training With Blood Flow Restriction Improves Clinical Outcomes in Musculoskeletal Rehabilitation: A Single-Blind Randomized Controlled Trial. Front Physiol. 2018 Sep 10;9:1269. doi: 10.3389/fphys.2018.01269. eCollection 2018.
Reference Type
BACKGROUND
Laurentino GC, Ugrinowitsch C, Roschel H, Aoki MS, Soares AG, Neves M Jr, Aihara AY, Fernandes Ada R, Tricoli V. Strength training with blood flow restriction diminishes myostatin gene expression. Med Sci Sports Exerc. 2012 Mar;44(3):406-12. doi: 10.1249/MSS.0b013e318233b4bc.
Reference Type
BACKGROUND
Loenneke JP, Thiebaud RS, Abe T, Bemben MG. Blood flow restriction pressure recommendations: the hormesis hypothesis. Med Hypotheses. 2014 May;82(5):623-6. doi: 10.1016/j.mehy.2014.02.023. Epub 2014 Mar 2.
Reference Type
BACKGROUND
Makhni EC, Higgins JD, Hamamoto JT, Cole BJ, Romeo AA, Verma NN. Patient Compliance With Electronic Patient Reported Outcomes Following Shoulder Arthroscopy. Arthroscopy. 2017 Nov;33(11):1940-1946. doi: 10.1016/j.arthro.2017.06.016. Epub 2017 Sep 27.
Reference Type
BACKGROUND
Manini TM, Yarrow JF, Buford TW, Clark BC, Conover CF, Borst SE. Growth hormone responses to acute resistance exercise with vascular restriction in young and old men. Growth Horm IGF Res. 2012 Oct;22(5):167-72. doi: 10.1016/j.ghir.2012.05.002. Epub 2012 Jun 23.
Reference Type
BACKGROUND
Manske R, Prohaska D. Superior labrum anterior to posterior (SLAP) rehabilitation in the overhead athlete. Phys Ther Sport. 2010 Nov;11(4):110-21. doi: 10.1016/j.ptsp.2010.06.004. Epub 2010 Jul 27.
Reference Type
BACKGROUND
Mascarenhas R, Verma NN. Editorial Commentary: Muscle Atrophy After Arthroscopic Rotator Cuff Repair-Reversible? Arthroscopy. 2016 Dec;32(12):2488-2489. doi: 10.1016/j.arthro.2016.08.007.
Reference Type
BACKGROUND
McLeod WD, Andrews JR. Mechanisms of shoulder injuries. Phys Ther. 1986 Dec;66(12):1901-4. doi: 10.1093/ptj/66.12.1901.
Reference Type
BACKGROUND
Meister K, Day T, Horodyski M, Kaminski TW, Wasik MP, Tillman S. Rotational motion changes in the glenohumeral joint of the adolescent/Little League baseball player. Am J Sports Med. 2005 May;33(5):693-8. doi: 10.1177/0363546504269936. Epub 2005 Feb 16.
Reference Type
BACKGROUND
Moore DR, Burgomaster KA, Schofield LM, Gibala MJ, Sale DG, Phillips SM. Neuromuscular adaptations in human muscle following low intensity resistance training with vascular occlusion. Eur J Appl Physiol. 2004 Aug;92(4-5):399-406. doi: 10.1007/s00421-004-1072-y.
Reference Type
BACKGROUND
Myers JB, Laudner KG, Pasquale MR, Bradley JP, Lephart SM. Glenohumeral range of motion deficits and posterior shoulder tightness in throwers with pathologic internal impingement. Am J Sports Med. 2006 Mar;34(3):385-91. doi: 10.1177/0363546505281804. Epub 2005 Nov 22.
Reference Type
BACKGROUND
Ohta H, Kurosawa H, Ikeda H, Iwase Y, Satou N, Nakamura S. Low-load resistance muscular training with moderate restriction of blood flow after anterior cruciate ligament reconstruction. Acta Orthop Scand. 2003 Feb;74(1):62-8. doi: 10.1080/00016470310013680.
Reference Type
BACKGROUND
Olesen JL, Heinemeier KM, Gemmer C, Kjaer M, Flyvbjerg A, Langberg H. Exercise-dependent IGF-I, IGFBPs, and type I collagen changes in human peritendinous connective tissue determined by microdialysis. J Appl Physiol (1985). 2007 Jan;102(1):214-20. doi: 10.1152/japplphysiol.01205.2005. Epub 2006 Sep 14.
Reference Type
BACKGROUND
Oyama S. Baseball pitching kinematics, joint loads, and injury prevention. Journal of Sport and Health Science. 2012;1(2):80-91.
Reference Type
BACKGROUND
Patterson SD, Ferguson RA. Increase in calf post-occlusive blood flow and strength following short-term resistance exercise training with blood flow restriction in young women. Eur J Appl Physiol. 2010 Mar;108(5):1025-33. doi: 10.1007/s00421-009-1309-x. Epub 2009 Dec 11.
Reference Type
BACKGROUND
Posner M, Cameron KL, Wolf JM, Belmont PJ Jr, Owens BD. Epidemiology of Major League Baseball injuries. Am J Sports Med. 2011 Aug;39(8):1676-80. doi: 10.1177/0363546511411700. Epub 2011 Jun 27.
Reference Type
BACKGROUND
Poton R, Polito MD. Hemodynamic response to resistance exercise with and without blood flow restriction in healthy subjects. Clin Physiol Funct Imaging. 2016 May;36(3):231-6. doi: 10.1111/cpf.12218. Epub 2014 Nov 27.
Reference Type
BACKGROUND
Reeves GV, Kraemer RR, Hollander DB, Clavier J, Thomas C, Francois M, Castracane VD. Comparison of hormone responses following light resistance exercise with partial vascular occlusion and moderately difficult resistance exercise without occlusion. J Appl Physiol (1985). 2006 Dec;101(6):1616-22. doi: 10.1152/japplphysiol.00440.2006. Epub 2006 Aug 10.
Reference Type
BACKGROUND
Rossi FE, de Freitas MC, Zanchi NE, Lira FS, Cholewa JM. The Role of Inflammation and Immune Cells in Blood Flow Restriction Training Adaptation: A Review. Front Physiol. 2018 Oct 9;9:1376. doi: 10.3389/fphys.2018.01376. eCollection 2018.
Reference Type
BACKGROUND
Ruotolo C, Price E, Panchal A. Loss of total arc of motion in collegiate baseball players. J Shoulder Elbow Surg. 2006 Jan-Feb;15(1):67-71. doi: 10.1016/j.jse.2005.05.006.
Reference Type
BACKGROUND
Sciore P, Boykiw R, Hart DA. Semiquantitative reverse transcription-polymerase chain reaction analysis of mRNA for growth factors and growth factor receptors from normal and healing rabbit medial collateral ligament tissue. J Orthop Res. 1998 Jul;16(4):429-37. doi: 10.1002/jor.1100160406.
Reference Type
BACKGROUND
Serrano AL, Baeza-Raja B, Perdiguero E, Jardi M, Munoz-Canoves P. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metab. 2008 Jan;7(1):33-44. doi: 10.1016/j.cmet.2007.11.011.
Reference Type
BACKGROUND
Shimizu R, Hotta K, Yamamoto S, Matsumoto T, Kamiya K, Kato M, Hamazaki N, Kamekawa D, Akiyama A, Kamada Y, Tanaka S, Masuda T. Low-intensity resistance training with blood flow restriction improves vascular endothelial function and peripheral blood circulation in healthy elderly people. Eur J Appl Physiol. 2016 Apr;116(4):749-57. doi: 10.1007/s00421-016-3328-8. Epub 2016 Jan 28.
Reference Type
BACKGROUND
Steinberg L. Baseball Has A Serious Injury Problem. Forbes. Available at: https://www.forbes.com/sites/leighsteinberg/2018/07/24/baseball-the-most-dangerous-sport-in-america/. Accessed November 2, 2018.
Reference Type
BACKGROUND
Takano H, Morita T, Iida H, Asada K, Kato M, Uno K, Hirose K, Matsumoto A, Takenaka K, Hirata Y, Eto F, Nagai R, Sato Y, Nakajima T. Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol. 2005 Sep;95(1):65-73. doi: 10.1007/s00421-005-1389-1. Epub 2005 Jun 15.
Reference Type
BACKGROUND
Takarada Y, Nakamura Y, Aruga S, Onda T, Miyazaki S, Ishii N. Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion. J Appl Physiol (1985). 2000 Jan;88(1):61-5. doi: 10.1152/jappl.2000.88.1.61.
Reference Type
BACKGROUND
Takarada Y, Takazawa H, Ishii N. Applications of vascular occlusion diminish disuse atrophy of knee extensor muscles. Med Sci Sports Exerc. 2000 Dec;32(12):2035-9. doi: 10.1097/00005768-200012000-00011.
Reference Type
BACKGROUND
Tennent DJ, Burns TC, Johnson AE, Owens JG, Hylden CM. Blood Flow Restriction Training for Postoperative Lower-Extremity Weakness: A Report of Three Cases. Curr Sports Med Rep. 2018 Apr;17(4):119-122. doi: 10.1249/JSR.0000000000000470. No abstract available.
Reference Type
BACKGROUND
Tennent DJ, Hylden CM, Johnson AE, Burns TC, Wilken JM, Owens JG. Blood Flow Restriction Training After Knee Arthroscopy: A Randomized Controlled Pilot Study. Clin J Sport Med. 2017 May;27(3):245-252. doi: 10.1097/JSM.0000000000000377.
Reference Type
BACKGROUND
Walch G, Boileau P, Noel E, Donell ST. Impingement of the deep surface of the supraspinatus tendon on the posterosuperior glenoid rim: An arthroscopic study. J Shoulder Elbow Surg. 1992 Sep;1(5):238-45. doi: 10.1016/S1058-2746(09)80065-7. Epub 2009 Feb 19.
Reference Type
BACKGROUND
Wall BT, Dirks ML, Snijders T, Senden JM, Dolmans J, van Loon LJ. Substantial skeletal muscle loss occurs during only 5 days of disuse. Acta Physiol (Oxf). 2014 Mar;210(3):600-11. doi: 10.1111/apha.12190. Epub 2013 Dec 5.
Reference Type
BACKGROUND
Werner SL, Gill TJ, Murray TA, Cook TD, Hawkins RJ. Relationships between throwing mechanics and shoulder distraction in professional baseball pitchers. Am J Sports Med. 2001 May-Jun;29(3):354-8. doi: 10.1177/03635465010290031701.
Reference Type
BACKGROUND
Werner SL, Guido JA Jr, Stewart GW, McNeice RP, VanDyke T, Jones DG. Relationships between throwing mechanics and shoulder distraction in collegiate baseball pitchers. J Shoulder Elbow Surg. 2007 Jan-Feb;16(1):37-42. doi: 10.1016/j.jse.2006.05.007. Epub 2006 Dec 12.
Reference Type
BACKGROUND
Wilk KE, Macrina LC, Fleisig GS, Aune KT, Porterfield RA, Harker P, Evans TJ, Andrews JR. Deficits in glenohumeral passive range of motion increase risk of elbow injury in professional baseball pitchers: a prospective study. Am J Sports Med. 2014 Sep;42(9):2075-81. doi: 10.1177/0363546514538391. Epub 2014 Jun 18.
Reference Type
BACKGROUND
Yasuda T, Loenneke JP, Thiebaud RS, Abe T. Effects of blood flow restricted low-intensity concentric or eccentric training on muscle size and strength. PLoS One. 2012;7(12):e52843. doi: 10.1371/journal.pone.0052843. Epub 2012 Dec 31.
Reference Type
BACKGROUND
Yoon MS. mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass. Front Physiol. 2017 Oct 17;8:788. doi: 10.3389/fphys.2017.00788. eCollection 2017.
Reference Type
BACKGROUND
Yow BG, Tennent DJ, Dowd TC, Loenneke JP, Owens JG. Blood Flow Restriction Training After Achilles Tendon Rupture. J Foot Ankle Surg. 2018 May-Jun;57(3):635-638. doi: 10.1053/j.jfas.2017.11.008. Epub 2018 Feb 21.
Reference Type
BACKGROUND
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
IRB00062859
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Exercise-induced Hypoalgesia Effects of Blood Flow Restriction in People With Rotator Cuff-related Shoulder Pain
NCT07232511
NOT_YET_RECRUITING
NA
Blood Flow Restriction Versus Standard Exercise After Rotator Cuff Repair
NCT06788327
NOT_YET_RECRUITING
NA
Blood Flow Restriction Exercise-induced Hypoalgesia
NCT06924112
NOT_YET_RECRUITING
NA
BFRT for Subacromial Pain
NCT06873113
RECRUITING
NA
Effects of a 4-week Low-intensity Training With Blood Flow Restriction in People With Rotator Cuff-related Shoulder Pain
NCT07324993
NOT_YET_RECRUITING
NA
Effects of Blood Flow Restriction Training in Rotator Cuff Related Shoulder Pain
NCT04834271
WITHDRAWN
NA
Can Blood Flow Restriction Therapy Improve Strength for Shoulder External Rotators Better Than Exercise Alone
NCT03815760
UNKNOWN
NA
Blood Flow Restriction Training for The Shoulder
NCT04540367
COMPLETED
NA
Comparison of Two Treatments for Acute Rotator Cuff Tendinopathy
NCT02813304
COMPLETED
NA
Blood Flow Restriction Training Versus Standard Physical Therapy After Shoulder Stabilization Surgery
NCT05506072
COMPLETED
NA
Rehabilitation: Closed-Chain Exercises for Rotator Cuff Tears
NCT02750176
COMPLETED
EARLY_PHASE1
The Effect of Cross-Education on Shoulder Arthroscopy
NCT04470570
COMPLETED
NA
Enhanced Function and Quality of Life Following 5 Months of Exercise Therapy for Patients With Rotator Cuff Tears
NCT02740946
COMPLETED
NA
Rehabilitation of Reconstructed Shoulder Rotator Cuff
NCT01499992
COMPLETED
NA
The Effect of a Bioactive Fabric Sleeve
NCT06234202
ACTIVE_NOT_RECRUITING
NA
Inclusion of Mobilisation With Movement to an Exercise Programme in Rotator Cuff Related Pain
NCT04175184
COMPLETED
NA
Therapeutic Exercise for Rotator Cuff Tendinopathy / Subacromial Pain Syndrome - Outcomes and Mechanisms
NCT04923477
RECRUITING
NA
A New Application in Subacromial Impingement Syndrome
NCT06324487
ACTIVE_NOT_RECRUITING
NA
Application of an Exercise Program Versus Exercise Plus Manual Therapy in the Treatment of Adhesive Capsulitis.
NCT06497348
NOT_YET_RECRUITING
NA
Blood Flow Restriction Training in Patients With Shoulder Pain
NCT04333784
COMPLETED
Telerehabilitation vs. In-person Physiotherapy in Young Elite Baseball Players
NCT07164625
ACTIVE_NOT_RECRUITING
NA
The Hypoalgesic Effects of BFR Training in Nonspecific Shoulder Pain.
NCT05956288
COMPLETED
NA
Effect of the Muscle Strength and Range of Motion Training for Post-platelet Rich Plasma Injection in People With Rotator Cuff Partial Tear
NCT06192459
RECRUITING
NA
Formal Physical Therapy (PT) vs. Home PT for Adhesive Capsulitis
NCT03049787
WITHDRAWN
NA