Identification of the Impact of Acute Pancreatitis on Quality of Life

NCT ID: NCT04222075

Last Updated: 2020-01-09

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-08-26
• Study Completion Date: 2022-09-01

Brief Summary

In abdomen, the pancreas as a gland is involved in the digestive and endocrine system by secreting digestive enzymes and insulin. Acute pancreatitis (AP) is a common inflammatory condition of the pancreas with symptoms of sudden abdominal pain and high temperature which may develop to severe complications in some patients. The incidence of AP was roughly 33.74 cases per 100, 000 person-years around the world but varies in different regions which America has the highest incidence of 58.20 cases per 100 000 person-years. There are very few studies published on AP in China, while Japanese national survey in 2011 estimated an incidence rate of 49.4 per 100,000 population and a study in Taiwan showed an annual average incidence of 36.9 per 100,000 persons with a slight change over ten years.

In most cases, patient with AP will start to recover within a week, but the patient quality of life (QoL) is still a big concern for disease management. It quantitatively measures the physical, mental and social wellbeing of individuals or their life satisfaction by questionnaires or surveys. Although very few studies have demonstrated the effect of AP on patient QoL, there is accumulating evidence to show its importance. Some studies reported no differences in QoL between AP patients and age-matched healthy people, whereas others showed QoL was significantly impaired due to AP. A large population-based follow-up study is needed to evaluate the impact of acute pancreatitis on quality of life. In addition, as the population investigated in most research was European based, the QoL evaluation of patients after AP among the Chinese population is also essential.

Conditions

Acute Pancreatitis; Quality of Life

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Acute Pancreatitis

Patients after acute pancreatitis

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Acute pancreatitis.
• Must be able to response an online survey.

Exclusion Criteria

• N/A

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Peking Union Medical College Hospital

OTHER

Sponsor Role: lead

Responsible Party

DONG WU

Associate Professor of Gastroenterology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

DONG WU, MD

Role: PRINCIPAL_INVESTIGATOR

Peking Union Medical College Hospital

Locations

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

DONG WU, MD

Role: CONTACT

dongwu@pumc.edu.cn

8618612671010

Facility Contacts

Dong Wu, M.D.

Role: primary

References

Pendharkar SA, Salt K, Plank LD, Windsor JA, Petrov MS. Quality of life after acute pancreatitis: a systematic review and meta-analysis. Pancreas. 2014 Nov;43(8):1194-200. doi: 10.1097/MPA.0000000000000189.

Reference Type: BACKGROUND

PMID: 25333403 (View on PubMed)

Machicado JD, Gougol A, Stello K, Tang G, Park Y, Slivka A, Whitcomb DC, Yadav D, Papachristou GI. Acute Pancreatitis Has a Long-term Deleterious Effect on Physical Health Related Quality of Life. Clin Gastroenterol Hepatol. 2017 Sep;15(9):1435-1443.e2. doi: 10.1016/j.cgh.2017.05.037. Epub 2017 Jun 1.

Reference Type: BACKGROUND

PMID: 28579182 (View on PubMed)

Ding H, Dai J, Lin J, Gong L, Sun H, Song K, Xie F, Wu D. A 12-month follow-up study of discharged patients with acute pancreatitis: An acute condition with prolonged sequela. Chin Med J (Engl). 2024 Jan 20;137(2):250-252. doi: 10.1097/CM9.0000000000002847. Epub 2023 Sep 5. No abstract available.

Reference Type: DERIVED

PMID: 37668021 (View on PubMed)

Other Identifiers

WD-2018APQOL

Identifier Type: -

Identifier Source: org_study_id