Comparison of Intravenous Co-amoxiclav Versus Benzyl Penicillin
NCT ID: NCT04215770
Last Updated: 2020-01-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
310 participants
INTERVENTIONAL
2018-01-01
2019-11-01
Brief Summary
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Detailed Description
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Safety was measured by frequency of hypersensitivity reactions or severe side effects of antibiotics necessitating stoppage of the drug. All the children in both Groups were given test dose of the antibiotic before giving full dose of antibiotic prescribed.
Cost effectiveness was compared in terms of total cost of injections (Co-amoxiclav versus Benzyl penicillin) which were administered to children in both groups.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Inj Co-amoxiclav
Group A children were advised Inj Co-amoxiclav 50 units/kg/day in 3 divided doses daily
inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day
Patients of both groups were examined and compared in terms of efficacy of treatment, safety and cost effectiveness
Inj Benzyl Penicillin
Group B patients were advised inj Benzyl Penicillin 25000 units/kg/day in 3 divided doses
inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day
Patients of both groups were examined and compared in terms of efficacy of treatment, safety and cost effectiveness
Interventions
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inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day
Patients of both groups were examined and compared in terms of efficacy of treatment, safety and cost effectiveness
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Children between ages of 5 to 15 years
3. Children with positive Rapid Antigen detection Test (RADT) for Streptococcus Pyogenes
Exclusion Criteria
2. Children with known hypersensitivity to Penicillins (esp Coamoxiclav and Benzyl penicillin)
3. Children with liver or renal failure
4. Children who were already using any oral or parenteral antibiotics
5 Years
15 Years
ALL
No
Sponsors
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Combined Military Hospital, Pakistan
OTHER
Responsible Party
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Ahmed Khan
ENT consultant
Principal Investigators
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Ahmed Khan, MBBS, FCPS
Role: PRINCIPAL_INVESTIGATOR
CMH Mardan
Locations
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CMH Mradan
Mardan, KPK, Pakistan
Countries
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Other Identifiers
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CMH-01-2019
Identifier Type: -
Identifier Source: org_study_id
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