Chromoendoscopy or Narrow Band Imaging (NBI) for Improving Adenoma Detection in Colonoscopy
NCT ID: NCT04192929
Last Updated: 2024-11-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
NA
INTERVENTIONAL
2025-02-28
2025-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SCREENING
SINGLE
Study Groups
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High definition white light endoscopy
colonoscopy performed using high definition equipment
High definition white light endoscopy
High definition equipment will be used to perform colonoscopy
Chromoendoscopy
indigo carmine is sprayed on the colon mucosa during withdrawal phase
Chromoendoscopy
Indigo carmine will be sprayed during withdrawal phase of colonoscopy
Narrow band imaging
Narrow band imaging is used during withdrawal phase
Narrow band imaging
Blue light is used during withdrawal phase instead of the regular white light to highlight surface changes
Interventions
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Narrow band imaging
Blue light is used during withdrawal phase instead of the regular white light to highlight surface changes
Chromoendoscopy
Indigo carmine will be sprayed during withdrawal phase of colonoscopy
High definition white light endoscopy
High definition equipment will be used to perform colonoscopy
Eligibility Criteria
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Inclusion Criteria
2. Referral for screening, surveillance or diagnostic colonoscopy
Exclusion Criteria
2. History of colorectal cancer or colon resection
3. Indication of positive FIT or cologuard
4. Any colorectal cancer syndromes (FAP, HNPCC, SPS)
5. Patient with poor bowel preparation identified during insertion
40 Years
ALL
Yes
Sponsors
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Indiana University
OTHER
Responsible Party
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Douglas K. Rex
Emeritus Professor of Medicine
Principal Investigators
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Douglas Rex, MD
Role: PRINCIPAL_INVESTIGATOR
IU
Locations
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Indiana University
Indianapolis, Indiana, United States
Countries
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References
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Wieszczy P, Regula J, Kaminski MF. Adenoma detection rate and risk of colorectal cancer. Best Pract Res Clin Gastroenterol. 2017 Aug;31(4):441-446. doi: 10.1016/j.bpg.2017.07.002. Epub 2017 Jul 6.
Brown SR, Baraza W, Din S, Riley S. Chromoscopy versus conventional endoscopy for the detection of polyps in the colon and rectum. Cochrane Database Syst Rev. 2016 Apr 7;4(4):CD006439. doi: 10.1002/14651858.CD006439.pub4.
Nagorni A, Bjelakovic G, Petrovic B. Narrow band imaging versus conventional white light colonoscopy for the detection of colorectal polyps. Cochrane Database Syst Rev. 2012 Jan 18;1(1):CD008361. doi: 10.1002/14651858.CD008361.pub2.
Leung WK, Lo OS, Liu KS, Tong T, But DY, Lam FY, Hsu AS, Wong SY, Seto WK, Hung IF, Law WL. Detection of colorectal adenoma by narrow band imaging (HQ190) vs. high-definition white light colonoscopy: a randomized controlled trial. Am J Gastroenterol. 2014 Jun;109(6):855-63. doi: 10.1038/ajg.2014.83. Epub 2014 Apr 22.
Atkinson NSS, Ket S, Bassett P, Aponte D, De Aguiar S, Gupta N, Horimatsu T, Ikematsu H, Inoue T, Kaltenbach T, Leung WK, Matsuda T, Paggi S, Radaelli F, Rastogi A, Rex DK, Sabbagh LC, Saito Y, Sano Y, Saracco GM, Saunders BP, Senore C, Soetikno R, Vemulapalli KC, Jairath V, East JE. Narrow-Band Imaging for Detection of Neoplasia at Colonoscopy: A Meta-analysis of Data From Individual Patients in Randomized Controlled Trials. Gastroenterology. 2019 Aug;157(2):462-471. doi: 10.1053/j.gastro.2019.04.014. Epub 2019 Apr 15.
Other Identifiers
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1912241137
Identifier Type: -
Identifier Source: org_study_id
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