Comparison of Brain Volumes Measured by 2D USG and MRI

NCT ID: NCT04190017

Last Updated: 2021-01-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-11-01

Study Completion Date

2022-03-30

Brief Summary

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Cranial USG is simple and easy method to assess preterm infant brain. Some studies showed that brain volumes of preterm infants could be calculated by measurement of 2D distances. Our aim in this study was to compare brain volume obtained by USG and MRI.

Detailed Description

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All preterm infants less than 32 weeks of gestational age undergo cranial USG examination routinely at least, in the first week of life, at the end of first month and corrected age 36 weeks and 40 weeks. We will performa all USG mesurements with measureing intracranial hegiht, anteroposterior diameter, biparietal diamater, ventriccular height, thalamo-occipital distance and ventricular index. We will calculate the brain volume as a spheric geometric shape than we will calculate two ventricles as conical shapes. Absolute brain volume will be calculating by substracting two ventricles from total brain volume. At 40 weeks of age we will perform a cranial MRI to show exact brain volume and we will ccompare two different methods.

Conditions

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Central Nervous System Vulnerabilities in Preterm Infants

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Cranial MRI

Cranial MRI

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All preterm infants under 32 weeks of gestational age and birth weight between 800-1200 grams
* Born in our hospital
* Alive during discharge

Exclusion Criteria

* congenital anomalies
* cranial bleeding
* early death
Minimum Eligible Age

1 Day

Maximum Eligible Age

3 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ankara City Hospital Bilkent

OTHER

Sponsor Role lead

Responsible Party

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Fuat Emre Canpolat

Assoc Prof Fuat Emre CANPOLAT MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mustafa Şenol Akın, MD

Role: STUDY_CHAIR

Ankara City Hospital Bilkent

Locations

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Ankara City Hospital

Ankara, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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FUAT EMRE CANPOLAT, MD

Role: CONTACT

05055668716

Facility Contacts

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Mustafa Şenol Akın, MD

Role: primary

+905558760585

References

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Benavente-Fernandez I, Lubian-Gutierrez M, Jimenez-Gomez G, Lechuga-Sancho AM, Lubian-Lopez SP; Neonatal Neurology Foundation (Fundacion Nene). Ultrasound lineal measurements predict ventricular volume in posthaemorrhagic ventricular dilatation in preterm infants. Acta Paediatr. 2017 Feb;106(2):211-217. doi: 10.1111/apa.13645. Epub 2016 Nov 21.

Reference Type BACKGROUND
PMID: 27783429 (View on PubMed)

Cheong JL, Thompson DK, Spittle AJ, Potter CR, Walsh JM, Burnett AC, Lee KJ, Chen J, Beare R, Matthews LG, Hunt RW, Anderson PJ, Doyle LW. Brain Volumes at Term-Equivalent Age Are Associated with 2-Year Neurodevelopment in Moderate and Late Preterm Children. J Pediatr. 2016 Jul;174:91-97.e1. doi: 10.1016/j.jpeds.2016.04.002. Epub 2016 May 9.

Reference Type BACKGROUND
PMID: 27174146 (View on PubMed)

Other Identifiers

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2019512-1

Identifier Type: -

Identifier Source: org_study_id

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