Hypermethylation of VTRNA2-1 Promoter in HCC Outcome

NCT ID: NCT04177316

Last Updated: 2019-11-26

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 92 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-12-01
• Study Completion Date: 2019-11-15

Brief Summary

The clinic-pathological data were retrieved from the cancer registry database from the Cancer Center of Chang Gung Memorial Hospital, Linkou branch. Of the 92 HCC patients with partial hepatectomies enrolled. The biological specimen was studied with approval.

Detailed Description

This study was approved by the Institute Review Board (IRB) of Chang Gung Memorial Hospital, Linkou Branch (IRB 201801969B0). The clinic-pathological data were retrieved from the cancer registry database from the Cancer Center of Chang Gung Memorial Hospital, Linkou branch. Of the 92 HCC patients with partial hepatectomies enrolled, all patients had curative hepatectomy and those with different cancers were excluded. HCC tumor tissue and normal tissue, 3 cm from the tumor margin, were stored immediately in a -80 degree freezer at the Central Biobank of Chang Gung Memorial Hospital. The personal information was protected with decoding and registered with number.

Conditions

Hepatocellular Carcinoma Resectable

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

hypermethylation

The hypermethylation group was defined as differential methylation status of tumor- normal ≥ 5%.

No interventions assigned to this group

hypomethylation/no change

The hypomethylation were defined as differential methylation status of tumor- normal \<5%

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

subjects with pathologic diagnosis of hepatocellular carcinoma curative partial hepatectomies

Exclusion Criteria

history of different malignant disease. subjects cannot be treated with curative surgery.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chang Gung Memorial Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ming-Chin Yu, MD, PhD

Role: STUDY_CHAIR

Chang Gung Memorial Hospital

Locations

Ming-Chin Yu

Taoyuan District, , Taiwan

Countries

Taiwan

Other Identifiers

201801969B0

Identifier Type: -

Identifier Source: org_study_id