Observation vs Early Removal of LAMS in EUS Guided Cholecystoenterostomy

NCT ID: NCT04167072

Last Updated: 2020-04-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-01

Study Completion Date

2021-01-31

Brief Summary

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The study will compare the outcomes of patients with gallstone related cholecystitis who are poor surgical candidates undergoing EUS guided cholecystoenterostomy via a lumen apposing metal stent (LAMS).

Detailed Description

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The study will include patients with stone related cholecystitis that are not adequate surgical candidates that will be treated with EUS guided cholecystoenterostomy with endoscopic stone extraction. Patients will be randomized to stent removal immediately after gallstones have been removed or to observation for 1 year with the stent in place. Outcomes to be measured include recurrence of stone disease and rate of complications from the procedure in both groups

Conditions

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Cholecystitis, Acute Cholecystitis; Gallstone

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Scheduled removal

This group involves patients who will have the LAMS removed immediately after all the stones have been cleared from the gallbladder

Group Type EXPERIMENTAL

Stent removal

Intervention Type PROCEDURE

This is a procedural intervention in which the stent will be removed via endoscopy.

Observation

This group involves patients who will be followed closely for 1 year after all the stones have been removed from the gallbladder. These patients will keep the stent in place for 1 year and at that time the patients will be offered removal of the stent.

Group Type ACTIVE_COMPARATOR

Stent removal

Intervention Type PROCEDURE

This is a procedural intervention in which the stent will be removed via endoscopy.

Interventions

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Stent removal

This is a procedural intervention in which the stent will be removed via endoscopy.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Ages 18-100 years or age
2. Both genders
3. Diagnosis of acute cholecystitis by TG13 criteria.
4. Patients who are able to give consent
5. Patients who are deemed poor surgical candidates for cholecystectomy by the surgical/medical team.

Exclusion Criteria

1. Unable to provide informed consent
2. Cardiorespiratory dysfunction that precludes sedation
3. Pregnant females
4. Presence of ascites (distance between duodenum and GB \> 1 cm) and/or coagulopathy (INR \> 3, PLT \<20K)
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Texas Tech University Health Sciences Center, El Paso

OTHER

Sponsor Role lead

Responsible Party

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Antonio Mendoza-Ladd

Assistant Professor of Medicine/Director of Endoscopy

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Medical Center of El Paso

El Paso, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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E20025

Identifier Type: -

Identifier Source: org_study_id

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