Yogurt for Prevention of Chronic Inflammation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-15

Study Completion Date

2022-09-01

Brief Summary

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The objective of this study is to conduct a randomized cross-over dietary intervention in adult women who are overweight or obese to compare how yogurt and a control food affect biomarkers of inflammation and intestinal health.

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Detailed Description

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Conditions

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Obesity Inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Yogurt-Control

Consumption of 12 oz. of low-fat yogurt daily (2 x 6 oz. servings) for 4 weeks, followed by a washout phase for 4 weeks, then consumption of 12 oz. control food (flavored soy pudding, 2 x 6 oz. servings) for 4 weeks.

Group Type EXPERIMENTAL

Yogurt

Intervention Type OTHER

Low-fat flavored yogurt

Control food

Intervention Type OTHER

Low-fat flavored soy pudding

Control-Yogurt

Consumption of control food (flavored soy pudding, 2 x 6 oz. servings), followed by a washout phase for 4 weeks, then consumption of 12 oz. of low-fat yogurt daily (2 x 6 oz. servings) for 4 weeks.

Group Type EXPERIMENTAL

Yogurt

Intervention Type OTHER

Low-fat flavored yogurt

Control food

Intervention Type OTHER

Low-fat flavored soy pudding

Interventions

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Yogurt

Low-fat flavored yogurt

Intervention Type OTHER

Control food

Low-fat flavored soy pudding

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* healthy premenopausal women age 21-55
* BMI ≥ 25 kg/m2
* not taking medication to control hypertension (e.g. anti-hypertensives or diuretics)
* resting blood pressure \<140/90 mmHg
* stable body weight for past two months
* willing to maintain a normal exercise level (in general)
* willing to avoid exercise and smoking (or other forms of nicotine intake) for 24 h prior to blood collection
* willing to avoid caffeine for 12 h before study visits
* willing to fast 12 h prior to study visits
* willing to avoid dietary supplements, yogurt and probiotic-containing foods (as necessary) and consume 12 oz. of yogurt and the control food per day (as necessary) for the duration of the study

Exclusion Criteria

* self-reported previous diagnoses of an inflammatory disease (e.g. inflammatory bowel disease, asthma, arthritis), CVD, diabetes, current cancer treatment (i.e., chemotherapy, radiation therapy)
* have used oral antibiotics in the prior 21 days before sample collection
* actively trying to lose weight
* regularly taking anti-inflammatory drugs
* vegetarian or allergic to soy or dairy
* are pregnant, lactating, or trying to become pregnant

Minimum Eligible Age

21 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes