Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism

NCT ID: NCT04146259

Last Updated: 2019-11-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

109 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2019-08-01

Brief Summary

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To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism

Detailed Description

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Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy.

Based on the development of biochemical hypocalcemia (cCa \< 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism.

Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels

Conditions

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Hypoparathyroidism Postprocedural

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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group A

Control

No interventions assigned to this group

Group B

Post-surgical hypoparathyroidism

calcium carbonate and alphacalcidol

Intervention Type DRUG

treatment for hypocalcemia

Interventions

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calcium carbonate and alphacalcidol

treatment for hypocalcemia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Indication for total thyroidectomy

Exclusion Criteria

* parathyroid disorders, chronic kidney disease (eGFR\< 60 ml/min), treatment with antiosteoporosis drugs, rheumatic disease and history of long term (\>1 month) or current corticosteroid use
Minimum Eligible Age

19 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University of Athens

OTHER

Sponsor Role lead

Responsible Party

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Symeon tournis

Senior Research Fellow

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Symeon Tournis

Athens, , Greece

Site Status

Countries

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Greece

Other Identifiers

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1387/08-12-2015

Identifier Type: -

Identifier Source: org_study_id

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