Changes in Metabolic Status in Patients With Total Thyroidectomy

NCT ID: NCT01781767

Last Updated: 2013-02-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-01-31

Study Completion Date

2014-07-31

Brief Summary

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This study objective is to evaluate the change in mitochondrial uncoupling protein 2 (UCP2) mRNA expression as function of thyroid activity (TSH, T3 and Free T4).

Detailed Description

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Blood will be drown before thyroidectomy, 2 weeks after the operation and 3-4 month after the operation.

Conditions

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Thyroid Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients who were diagnosed with thyroid carcinoma and are going to have total thyroidectomy.
* Patients with unbalanced thyroid hormones.
* Aged 18-65 years at the time of screening.
* Provision of written informed consent.

Exclusion Criteria

* Patients with Diabetes.
* Patients with any other chronic inflammatory diseases.
* Steroid treatment.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tel-Aviv Sourasky Medical Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Tel Aviv Sourasky Medical Center

Tel Aviv, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Nachum Vaisman, M.D.

Role: CONTACT

972-3-6974807

Facility Contacts

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Nachum Vaisman, M.D.

Role: primary

972-3-6974807

References

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Yen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev. 2001 Jul;81(3):1097-142. doi: 10.1152/physrev.2001.81.3.1097.

Reference Type BACKGROUND
PMID: 11427693 (View on PubMed)

Schwartz HL, Oppenheimer JH. Physiologic and biochemical actions of thyroid hormone. Pharmacol Ther B. 1978;3(3):349-76. doi: 10.1016/s0306-039x(78)80002-6. No abstract available.

Reference Type BACKGROUND
PMID: 203955 (View on PubMed)

Brand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2005 Aug;2(2):85-93. doi: 10.1016/j.cmet.2005.06.002.

Reference Type BACKGROUND
PMID: 16098826 (View on PubMed)

Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev. 1984 Jan;64(1):1-64. doi: 10.1152/physrev.1984.64.1.1. No abstract available.

Reference Type BACKGROUND
PMID: 6320232 (View on PubMed)

Gjedde S, Gormsen LC, Riis AL, Jorgensen JO, Rungby J, Moller N, Weeke J, Pedersen SB. Reduced expression of uncoupling protein 2 in adipose tissue in patients with hypothyroidism. J Clin Endocrinol Metab. 2010 Jul;95(7):3537-41. doi: 10.1210/jc.2009-0907. Epub 2010 Apr 28.

Reference Type BACKGROUND
PMID: 20427509 (View on PubMed)

Other Identifiers

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TASMC-12-NV-376-CTIL

Identifier Type: -

Identifier Source: org_study_id

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