Behavioral Assessment of Nociception on NCS-R

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

140 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-08-01

Study Completion Date

2019-05-26

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study was to investigate the relationship between behaviorally assessed consciousness levels and responsiveness to nociception in patients with disorders of consciousness (DOC)

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Diagnostic Accuracy of the Vegetative and Minimally Conscious State

NCT04139239

Disorder of Consciousness Minimally Conscious State

COMPLETED

Reliability and Validity of the NCS (NCS-R)-Chinese Version

NCT03494218

Minimally Conscious State Vegetative State

COMPLETED NA

Micro-movements in Patients With Prolonged Disorders of Consciousness

NCT06406413

Consciousness Disorders

RECRUITING

Effects of Different Stimuli in Patients With Disorders of Consciousness

NCT03385291

Disorder of Consciousness

COMPLETED NA

Neurophysiological Evaluation of Residual Cognitive Functions in Patients With Severe Alterations of Consciousness

NCT05802524

Consciousness Disorder Cognitive Impairment

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Patients with a clinical consensus of DOC were enrolled. The Coma Recovery Scale-Revised (CRS-R) was used to assess the DOC patients' consciousness levels and the Nociception Coma Scale-Revised (NCS-R) was used to evaluate their pain response over one week. Furthermore, the relationship between behaviorally assessed consciousness levels and pain response was analyzed.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Disorder of Consciousness Unresponsive Wakefulness Syndrome Minimally Conscious State

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients with disorders of consciousness

The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)

Intervention Type DIAGNOSTIC_TEST

All enrolled DOC patients were evaluated at least five times over one week by two trained professionals using the Chinese version of the CRS-R. During the evaluation of the patient's consciousness level, the NCS-R was used to evaluate the pain response of all patients in random order at least once, and the best behavioral response (i.e., the highest score) of each subscale was recorded during resting, noxious, and physiotherapy conditions, respectively, according to the NCS-R guidelines.

Patients with unresponsive wakefulness syndrome

The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)

Intervention Type DIAGNOSTIC_TEST

All enrolled DOC patients were evaluated at least five times over one week by two trained professionals using the Chinese version of the CRS-R. During the evaluation of the patient's consciousness level, the NCS-R was used to evaluate the pain response of all patients in random order at least once, and the best behavioral response (i.e., the highest score) of each subscale was recorded during resting, noxious, and physiotherapy conditions, respectively, according to the NCS-R guidelines.

Patients with minimally conscious state

The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)

Intervention Type DIAGNOSTIC_TEST

All enrolled DOC patients were evaluated at least five times over one week by two trained professionals using the Chinese version of the CRS-R. During the evaluation of the patient's consciousness level, the NCS-R was used to evaluate the pain response of all patients in random order at least once, and the best behavioral response (i.e., the highest score) of each subscale was recorded during resting, noxious, and physiotherapy conditions, respectively, according to the NCS-R guidelines.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)

All enrolled DOC patients were evaluated at least five times over one week by two trained professionals using the Chinese version of the CRS-R. During the evaluation of the patient's consciousness level, the NCS-R was used to evaluate the pain response of all patients in random order at least once, and the best behavioral response (i.e., the highest score) of each subscale was recorded during resting, noxious, and physiotherapy conditions, respectively, according to the NCS-R guidelines.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* (1) at least 18 years old
* (2) acquired brain injury
* (3) no neuromuscular blockers or sedatives used within 72 hours of enrollment.

Exclusion Criteria

* (1) functional disorders caused by progressive mental diseases
* (2) persistent seizures
* (3) unstable vital signs
* and/or (4) double upper-limb frustration, fracture.

Minimum Eligible Age

20 Years

Maximum Eligible Age

84 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No