Effect of Iron Deficiency Anemia on HBA1C in Patients With Diabetic Foot Ulcer Grade (1and2)

NCT ID: NCT04131608

Last Updated: 2021-01-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-01

Study Completion Date

2021-12-01

Brief Summary

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Diabetic foot ulcer is the commonest cause of severe limb ischemia in diabetes mellitus And development of anemia is an additional burden to the microvascular complications of diabetes

Detailed Description

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HBA1C is the predominant Hemoglobin found in HBA1 fraction and it constitutes 5% of total Hemoglobin in normal adults and up to 15%in patients with diabetes mellitus HBA1C is used to diagnose diabetes and to identify individuals that are at high risk for developing diabetes Iron deficiency anemia is one of the most prevalent form of malnutrition affect 1,62 billion people whish correspond to 24,8%of the world population Ferritin is the storage form of iron so it is found to be test for distinguishing those with iron deficiency anemia from those who are not iron deficient

Conditions

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Iron Deficiency Anemia HBA1C

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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diabetic foot ulcer (1and2)with iron defic

50 diabetic patients with diabetic foot ulcer grade (1and2) with iron deficiency anemia will be applied TO

1. cbc
2. ferritin
3. HBA1C
4. ankle brachial index by duplex

CBC ,Serum ferritin ,HBA1C

Intervention Type DIAGNOSTIC_TEST

Diabetic patients will be applied to CBC, HBA1C and serum ferritin

diabetic foot ulcer grade(1and2)without iron deficiency anemia

50 patients with diabetic foot ulcer grade (1and2) without iron deficiency anemia will be applied to

1. CBC
2. Ferritin,
3. HBA1C
4. ankle brachial index by duplex

CBC ,Serum ferritin ,HBA1C

Intervention Type DIAGNOSTIC_TEST

Diabetic patients will be applied to CBC, HBA1C and serum ferritin

Interventions

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CBC ,Serum ferritin ,HBA1C

Diabetic patients will be applied to CBC, HBA1C and serum ferritin

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Ankle brachial index by duplex

Eligibility Criteria

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Inclusion Criteria

* all diabetic patients with diabetic foot ulcer grade one and two above 18 year

Exclusion Criteria

1. patients with anemia other than iron deficiency anemia
2. Patients on anticoagulants
3. patients with blood disease 4-patients below 18
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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MSSAMIR

Resident doctor at INTERNAL medicine department assiut university hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Marina Samir Fawzy, Resident

Role: CONTACT

01271389378

Manal Al Sayed Ezz El Deen, Associated professor

Role: CONTACT

01005826070

References

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Kim S, Min WK, Chun S, Lee W, Park HI. Glycated albumin may be a possible alternative to hemoglobin A1c in diabetic patients with anemia. Clin Chem Lab Med. 2011 Oct;49(10):1743-7. doi: 10.1515/CCLM.2011.646. Epub 2011 Jun 17.

Reference Type BACKGROUND
PMID: 21679130 (View on PubMed)

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010 Jan;33 Suppl 1(Suppl 1):S62-9. doi: 10.2337/dc10-S062. No abstract available.

Reference Type BACKGROUND
PMID: 20042775 (View on PubMed)

Kim C, Bullard KM, Herman WH, Beckles GL. Association between iron deficiency and A1C Levels among adults without diabetes in the National Health and Nutrition Examination Survey, 1999-2006. Diabetes Care. 2010 Apr;33(4):780-5. doi: 10.2337/dc09-0836. Epub 2010 Jan 12.

Reference Type BACKGROUND
PMID: 20067959 (View on PubMed)

Wolffenbuttel BH, Herman WH, Gross JL, Dharmalingam M, Jiang HH, Hardin DS. Ethnic differences in glycemic markers in patients with type 2 diabetes. Diabetes Care. 2013 Oct;36(10):2931-6. doi: 10.2337/dc12-2711. Epub 2013 Jun 11.

Reference Type BACKGROUND
PMID: 23757434 (View on PubMed)

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014 Jan;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081. No abstract available.

Reference Type BACKGROUND
PMID: 24357215 (View on PubMed)

Other Identifiers

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HBA1C and anemia

Identifier Type: -

Identifier Source: org_study_id

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