Differential Expression and Analysis of Peripheral Plasma Exosome miRNA in Patients With Myocardial Infarction

NCT ID: NCT04127591

Last Updated: 2019-10-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-20

Study Completion Date

2021-12-30

Brief Summary

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The aim of this study is to determine the miRNA expression profile in peripheral blood exosomes of patients with myocardial infarction and to investigate its relationship with myocardial infarction.

Detailed Description

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Collect exosomes in peripheral blood of patients with myocardial infarction, compare the expression of miRNA with healthy volunteers, find out the miRNAs with significant differences, and explore its relationship with the development of myocardial infarction.

Conditions

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Myocardial Infarction

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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myocardial infarction group

Patients admitted with the diagnosis of myocardial infarction.

exosome

Intervention Type OTHER

Collect exosomes in peripheral blood of patients and extract miRNAs from them.

Blank control group

Patients admitted without the diagnosis of myocardial infarction.

exosome

Intervention Type OTHER

Collect exosomes in peripheral blood of patients and extract miRNAs from them.

Interventions

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exosome

Collect exosomes in peripheral blood of patients and extract miRNAs from them.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 years ST elevation by ECG diagnostic of STEMI Evidency of coronary occlusion in coronariography Signed informed consent

Exclusion Criteria

* Patients who will undergo immediate PCI Pregnant and lactating women Patients with mental disorders Patients are using other experimental drugs; Refusal to provide informed.
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Bin He

M.D./Ph.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ethics Committee of Xinhua Hospital

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Central Contacts

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Bin He

Role: CONTACT

021-25077828

Other Identifiers

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XH-19-010

Identifier Type: -

Identifier Source: org_study_id

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